2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Acute Pain D059787 3 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Fagundo AB et al. Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. 2013 PLoS ONE pmid:23840456
Sergi M et al. Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS. 2013 Anal Bioanal Chem pmid:22847477
Ueda N et al. Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. 2013 FEBS J. pmid:23425575
Sugaya Y et al. The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. 2013 J. Neurosci. pmid:23426686
DiPatrizio NV et al. Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. 2013 FASEB J. pmid:23463697
Su LD et al. Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. 2013 Cerebellum pmid:23307660
Keimpema E et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23319656
Shimizu T et al. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. 2013 J. Pharmacol. Sci. pmid:23386378
Tchantchou F and Zhang Y Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. 2013 J. Neurotrauma pmid:23151067
Neumeister A et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. 2013 Mol. Psychiatry pmid:23670490
Jain T et al. Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. 2013 Mol. Pharmacol. pmid:23748223
Citraro R et al. Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. 2013 Neuropharmacology pmid:23206503
Signorello MG et al. The 2-arachidonoylglycerol effect on myosin light chain phosphorylation in human platelets. 2013 Biochimie pmid:23702422
Higgins A et al. Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids. 2013 Mol Pain pmid:23725095
Almeida-Santos AF et al. Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. 2013 Behav. Brain Res. pmid:23714073
Perez-Rosello T et al. Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. 2013 J. Neurosci. pmid:23719795
Yang Y et al. Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. 2013 Cell. Signal. pmid:23142606
Guindon J et al. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. 2013 Pharmacol. Res. pmid:23127915
Frazier CJ Preformed vs. on-demand: molecular economics of endocannabinoid signalling. 2013 J. Physiol. (Lond.) pmid:24085490
Starowicz K et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. 2013 PLoS ONE pmid:23573230
Subbanna S et al. Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. 2013 J. Neurosci. pmid:23575834
Morgan CJ et al. Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. 2013 Br J Psychiatry pmid:23580381
Bisogno T et al. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. 2013 Br. J. Pharmacol. pmid:23072382
Blankman JL and Cravatt BF Chemical probes of endocannabinoid metabolism. 2013 Pharmacol. Rev. pmid:23512546
Berge K et al. Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. 2013 Lipids Health Dis pmid:23706001
Zygmunt PM et al. Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. 2013 PLoS ONE pmid:24312564
Wang R et al. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. 2013 Biochemistry pmid:24083319
Ikeda H et al. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. 2013 Neuroscience pmid:23892011
Yuan S and Burrell BD Nonnociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism. 2013 J. Neurophysiol. pmid:24027102
Hill MN et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. 2013 Psychoneuroendocrinology pmid:24035186
Blasio A et al. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. 2013 Neuropsychopharmacology pmid:23793355
Malenczyk K et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. 2013 J. Biol. Chem. pmid:24089517
Brocato B et al. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. 2013 Placenta pmid:24008071
Baur R et al. Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors. 2013 J. Neurochem. pmid:23600744
Fonseca BM et al. Endogenous cannabinoids revisited: a biochemistry perspective. 2013 Apr-May Prostaglandins Other Lipid Mediat. pmid:23474290
Pascual AC et al. Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. 2013 Mar-Apr Biofactors pmid:23281018
den Boon FS et al. Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. 2014 Pflugers Arch. pmid:24671573
Shonesy BC et al. Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. 2014 Cell Rep pmid:25466252
Gasperi V et al. 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. 2014 Cell Cycle pmid:25427281
Zhang J et al. Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. 2014 J. Neurosci. pmid:25378159
Fezza F et al. Endocannabinoids, related compounds and their metabolic routes. 2014 Molecules pmid:25347455
Flores-Otero J et al. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. 2014 Nat Commun pmid:25081814
Smaga I et al. Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures. 2014 Neurotox Res pmid:24652522
Nithipatikom K et al. A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. 2014 J. Lipid Res. pmid:24958911
Kohnz RA and Nomura DK Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. 2014 Chem Soc Rev pmid:24676249
Pastor A et al. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. 2014 J. Lipid Res. pmid:24610889
Stanley CP and O'Sullivan SE Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. 2014 Pharmacol. Res. pmid:24548820
Pérez-Morales M et al. 2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation. 2014 Neuroreport pmid:25356522
Signorello MG and Leoncini G Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. 2014 Biochimie pmid:25068972
Fernández-Suárez D et al. Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. 2014 Neurobiol. Aging pmid:24973119
Petrenko AB et al. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. 2014 Behav. Brain Res. pmid:24906199
Tsurumura T and Tsuge H Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. 2014 J. Struct. Funct. Genomics pmid:24894647
Pascual AC et al. Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging. 2014 Exp. Gerontol. pmid:24768821
Gasperi V et al. 2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors. 2014 Int. J. Biochem. Cell Biol. pmid:24721209
Lu Y et al. Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. 2014 J. Mol. Neurosci. pmid:24510751
Alhouayek M et al. Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. 2014 Drug Discov. Today pmid:23891880
Morena M et al. Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25489086
Khasabova IA et al. JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy. 2014 Pharmacol. Res. pmid:25304184
McDougle DR et al. Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. 2014 J. Pharmacol. Exp. Ther. pmid:25277139
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
Lau BK et al. Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. 2014 Br. J. Pharmacol. pmid:25041240
Laprairie RB et al. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. 2014 J. Biol. Chem. pmid:25037227
Cipriano M et al. The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. 2014 BMC Res Notes pmid:25012825
Navarria A et al. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. 2014 Pharmacol. Res. pmid:24861565
Nader J et al. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. 2014 Neuropharmacology pmid:24709540
Sun LJ et al. Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. 2014 Int. J. Infect. Dis. pmid:24704332
Basavarajappa BS et al. Elevation of endogenous anandamide impairs LTP, learning, and memory through CB1 receptor signaling in mice. 2014 Hippocampus pmid:24648181
Oleson EB et al. Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. 2014 Neuropsychopharmacology pmid:24345819
Larose MC et al. Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. 2014 J. Allergy Clin. Immunol. pmid:24530098
Abdulnour J et al. Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. 2014 Obesity (Silver Spring) pmid:23616305
Aaltonen N et al. Brain regional cannabinoid CB(1) receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice. 2014 Eur J Pharm Sci pmid:24012970
Brantl SA et al. Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. 2014 Platelets pmid:24102401
Brantl SA et al. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. 2014 Platelets pmid:23789792
Iannotti FA et al. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24927567
Tiburu EK and Shen L Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. 2014 J. Membr. Biol. pmid:24402242
Costa MA et al. 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. 2014 Reproduction pmid:24324206
Laitinen T et al. Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. 2014 Mol. Pharmacol. pmid:24368842
Koltyn KF et al. Mechanisms of exercise-induced hypoalgesia. 2014 J Pain pmid:25261342
Melis M et al. Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. 2014 J. Neurosci. pmid:25232109
Murataeva N et al. Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. 2014 Br. J. Pharmacol. pmid:24102242
Yasuo S et al. 2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters. 2014 Chronobiol. Int. pmid:24200164
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Pertwee RG Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. 2014 Proc Nutr Soc pmid:24135210
Burston JJ and Woodhams SG Endocannabinoid system and pain: an introduction. 2014 Proc Nutr Soc pmid:24148358
Desroches J et al. Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors. 2014 Neuropharmacology pmid:24148808
Yang K et al. Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. 2014 Hippocampus pmid:25087967
Fezza F et al. Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. 2014 Mol. Cell. Neurosci. pmid:25064144
Pulgar VM et al. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. 2014 Hypertension pmid:24935942
Jergas B et al. O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. 2014 Naunyn Schmiedebergs Arch. Pharmacol. pmid:24853577
Pava MJ et al. Endocannabinoid modulation of cortical up-states and NREM sleep. 2014 PLoS ONE pmid:24520411
Sanson B et al. Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. 2014 Acta Crystallogr. D Biol. Crystallogr. pmid:24531463
Ohno-Shosaku T and Kano M Endocannabinoid-mediated retrograde modulation of synaptic transmission. 2014 Curr. Opin. Neurobiol. pmid:24747340
Chianese R et al. Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis. 2014 Gen. Comp. Endocrinol. pmid:24566122
Rea K et al. Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. 2014 Eur. J. Neurosci. pmid:24494683
Zheng Y et al. Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. 2014 Eur. J. Pharmacol. pmid:24508383
Krishnan G and Chatterjee N Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. 2014 Mol. Cell. Neurosci. pmid:24418364
Nicolussi S et al. Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. 2014 Pharmacol. Res. pmid:24412246
Limebeer CL et al. Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. 2014 Psychopharmacology (Berl.) pmid:24043345
Kim J and Watkins BA Cannabinoid receptor antagonists and fatty acids alter endocannabinoid system gene expression and COX activity. 2014 J. Nutr. Biochem. pmid:24854955
Manna JD et al. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. 2014 J. Biol. Chem. pmid:25301951