| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Starvation | D013217 | 47 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zou Z et al. | Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. | 2016 | J. Mol. Neurosci. | pmid:27129498 |
| Keyshams N et al. | Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors. | 2016 | Vet. Res. Commun. | pmid:27000110 |
| Feliszek M et al. | Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26984820 |
| Zhang L et al. | Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. | 2016 | Neuroscience | pmid:26924019 |
| Tomas-Roig J et al. | Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. | 2016 | Behav. Brain Res. | pmid:26815100 |
| Siegmund SV et al. | Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26801558 |
| González-Mariscal I et al. | Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. | 2016 | Mol. Cell. Endocrinol. | pmid:26724516 |
| Lu HC and Mackie K | An Introduction to the Endogenous Cannabinoid System. | 2016 | Biol. Psychiatry | pmid:26698193 |
| Sanchez AM et al. | Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. | 2016 | Reprod Sci | pmid:26887427 |
| Morena M et al. | Neurobiological Interactions Between Stress and the Endocannabinoid System. | 2016 | Neuropsychopharmacology | pmid:26068727 |
| Knani I et al. | Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. | 2016 | Mol Metab | pmid:27900261 |
| Liu X et al. | Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. | 2016 | Sci Rep | pmid:27775008 |
| Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
| Kudalkar SN et al. | Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. | 2016 | Methods Mol. Biol. | pmid:27245906 |
| Jung KM and Piomelli D | Assay of Monoacylglycerol Lipase Activity. | 2016 | Methods Mol. Biol. | pmid:27245902 |
| Reddy IA et al. | Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. | 2016 | Transl Psychiatry | pmid:27187231 |
| Gray JM et al. | Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. | 2016 | Psychoneuroendocrinology | pmid:26821211 |
| Doenni VM et al. | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. | 2016 | Brain Behav. Immun. | pmid:27453335 |
| Artegoitia VM et al. | Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. | 2016 | J. Anim. Sci. | pmid:28046144 |
| Dong L et al. | Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. | 2016 | J. Lipid Res. | pmid:27059979 |
| Schlabritz-Loutsevitch N et al. | Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. | 2016 | Med. Hypotheses | pmid:27959272 |
| van Zadelhoff G and van der Stelt M | Oxygenation of Anandamide by Lipoxygenases. | 2016 | Methods Mol. Biol. | pmid:27245907 |
| Martella A et al. | Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. | 2016 | Endocrinology | pmid:27014939 |
| Iannotti FA et al. | Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. | 2016 | Prog. Lipid Res. | pmid:26965148 |
| Gamelin FX et al. | Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. | 2016 | J. Physiol. Biochem. | pmid:26880264 |
| Leishman E et al. | Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. | 2016 | Pharmacol. Res. | pmid:27109320 |
| Rajaraman G et al. | G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. | 2016 | Mol Nutr Food Res | pmid:26337420 |
| Di S et al. | Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. | 2016 | J. Neurosci. | pmid:27511017 |
| Aaltonen N et al. | In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). | 2016 | J. Pharmacol. Exp. Ther. | pmid:27451409 |
| Sharkey KA and Wiley JW | The Role of the Endocannabinoid System in the Brain-Gut Axis. | 2016 | Gastroenterology | pmid:27133395 |
| Sido JM et al. | Production of endocannabinoids by activated TÂ cells and BÂ cells modulates inflammation associated with delayed-type hypersensitivity. | 2016 | Eur. J. Immunol. | pmid:27064137 |
| Brose SA et al. | Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. | 2016 | Lipids | pmid:27021494 |
| Aso C et al. | Protein purification and cloning of diacylglycerol lipase from rat brain. | 2016 | J. Biochem. | pmid:26790472 |
| Buczynski MW et al. | Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26755579 |
| Ogasawara D et al. | Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26668358 |
| Hanlon EC et al. | Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. | 2016 | Sleep | pmid:26612385 |
| Vujic N et al. | Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. | 2016 | Atherosclerosis | pmid:26584135 |
| Mann A et al. | Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? | 2016 | J Basic Clin Physiol Pharmacol | pmid:26565551 |
| Grabner GF et al. | Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. | 2016 | J. Biol. Chem. | pmid:26565024 |
| Sticht MA et al. | Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. | 2016 | Neuropharmacology | pmid:26541329 |
| McReynolds JR et al. | CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. | 2016 | Psychopharmacology (Berl.) | pmid:26455361 |
| Lim J et al. | Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. | 2016 | Neuropsychopharmacology | pmid:26361059 |
| Stark DT and Caprioli J | Subcellular Localization of a 2-Arachidonoyl Glycerol Signaling Cassette in Retinal Ganglion Cell Axonal Growth In Vitro. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:28002563 |
| Cristino L et al. | Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency. | 2016 | Neuropsychopharmacology | pmid:26081302 |
| Wiley JL et al. | Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. | 2016 | Behav Pharmacol | pmid:27385208 |
| Janssen FJ and van der Stelt M | Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27394666 |
| Mwanza C et al. | Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27318292 |
| Bisogno T | Assay of DAGLα/β Activity. | 2016 | Methods Mol. Biol. | pmid:27245901 |
| Battista N and Sergi M | Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. | 2016 | Methods Mol. Biol. | pmid:27245888 |
| Liisberg U et al. | Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. | 2016 | J. Nutr. Biochem. | pmid:27155918 |