2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Hepatic Encephalopathy D006501 9 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Glioma D005910 112 associated lipids
Obesity D009765 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Starvation D013217 47 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Yasuo S et al. Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man. 2010 Cell Tissue Res. pmid:20957495
Arevalo-Martin A et al. The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. 2010 Neurobiol. Dis. pmid:20156559
Eisenstein SA et al. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. 2010 Pharmacol. Res. pmid:20044005
Frampton G et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. 2010 Exp. Cell Res. pmid:20347808
Kim J and Alger BE Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. 2010 Nat. Neurosci. pmid:20348918
Hoot MR et al. Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. 2010 Brain Res. pmid:20380816
Caraceni P et al. Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. 2010 Liver Int. pmid:19840245
Piccinetti CC et al. Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. 2010 Gen. Comp. Endocrinol. pmid:19800340
Banni S and Di Marzo V Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. 2010 Mol Nutr Food Res pmid:20013888
Fonseca BM et al. The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: a role in uterine remodelling. 2010 Int. J. Biochem. Cell Biol. pmid:20727980
Lerner TN et al. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. 2010 J. Neurosci. pmid:20147543
Reggio PH Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. 2010 Curr. Med. Chem. pmid:20166921
Weis F et al. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. 2010 J. Mol. Cell. Cardiol. pmid:19931541
Sang N et al. Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. 2010 Neurochem. Int. pmid:20064571
Maccarrone M et al. Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. 2010 Neuropsychopharmacology pmid:20393458
Hurst DP et al. A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. 2010 J. Biol. Chem. pmid:20220143
Telleria-Diaz A et al. Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. 2010 Pain pmid:19879047
Bradshaw H CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. 2010 Pain pmid:19913999
Zhang MY et al. Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. 2010 J Mass Spectrom pmid:19950120
Labar G et al. Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. 2010 Chembiochem pmid:19957260
Frazier CJ Key questions of endocannabinoid signalling in the CNS: which, where and when? 2011 J. Physiol. (Lond.) pmid:22001725
Nomura DK et al. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. 2011 Science pmid:22021672
Muppidi JR et al. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. 2011 J. Exp. Med. pmid:21875957
Zhang L et al. Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. 2011 PLoS ONE pmid:21305054
Schalk-Hihi C et al. Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Ã… resolution. 2011 Protein Sci. pmid:21308848
Duggan KC et al. (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. 2011 Nat. Chem. Biol. pmid:22053353
Puente N et al. Polymodal activation of the endocannabinoid system in the extended amygdala. 2011 Nat. Neurosci. pmid:22057189
Stella N Cell biology. Anatomy of prostaglandin signals. 2011 Science pmid:22076368
Patsenker E et al. Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. 2011 Mol. Med. pmid:21863215
Hill MN et al. Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. 2011 J. Neurosci. pmid:21775596
Sumislawski JJ et al. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. 2011 Neuropsychopharmacology pmid:21849983
Zhong P et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. 2011 J. Physiol. (Lond.) pmid:21911610
Marazzi J et al. Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. 2011 J. Immunol. Methods pmid:21920367
Signorello MG et al. Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway. 2011 J. Cell. Biochem. pmid:21608016
Du H et al. Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. 2011 Br. J. Pharmacol. pmid:21501147
Raman P et al. 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. 2011 Mol. Pharmacol. pmid:21511917
Bari M et al. Characterization of the endocannabinoid system in mouse embryonic stem cells. 2011 Stem Cells Dev. pmid:20446814
Higuchi S et al. Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. 2011 Behav. Brain Res. pmid:20817042
Ludányi A et al. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. 2011 Neuroscience pmid:21035522
Hofmann ME et al. Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. 2011 J. Physiol. (Lond.) pmid:21646412
Martín-Couce L et al. Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. 2011 J. Med. Chem. pmid:21675776
Chanda D et al. Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. 2011 J. Biol. Chem. pmid:21693703
Busquets-Garcia A et al. Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. 2011 Biol. Psychiatry pmid:21684528
Signorello MG et al. Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO/cGMP pathway modulation. 2011 Curr Neurovasc Res pmid:21675954
Sarmad S et al. Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. 2011 J. Neurochem. pmid:21375532
Marrs WR et al. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. 2011 J. Biol. Chem. pmid:21665953
Gantayet A et al. Endocannabinoids and diacylglycerol kinase activity. 2011 Biochim. Biophys. Acta pmid:21194521
Duclos RI et al. A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). 2011 J. Org. Chem. pmid:21370840
Shimizu T et al. Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats. 2011 Eur. J. Pharmacol. pmid:21371452
Lourbopoulos A et al. Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. 2011 Brain Res. pmid:21406188
Kortleven C et al. The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. 2011 Eur. J. Neurosci. pmid:21410793
Oudin MJ et al. Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. 2011 J. Neurosci. pmid:21411643
Hashimotodani Y et al. Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. 2011 J. Neurosci. pmid:21414931
Howlett AC et al. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. 2011 Br. J. Pharmacol. pmid:21545414
Taschler U et al. Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. 2011 J. Biol. Chem. pmid:21454566
Mulder J et al. Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. 2011 Brain pmid:21459826
Carr RL et al. Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. 2011 Toxicol. Sci. pmid:21507991
Chiba T et al. A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. 2011 J. Pharm. Pharmacol. pmid:21492165
Vecchio AJ and Malkowski MG The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. 2011 J. Biol. Chem. pmid:21489986
Balenga NA et al. GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. 2011 Cell Res. pmid:21467997
Chen X et al. Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. 2011 Neuroscience pmid:21256197
Yoshida T et al. Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21282604
Liao HT et al. Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. 2011 Br. J. Pharmacol. pmid:21232043
Soderstrom K et al. Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. 2011 BMC Neurosci pmid:21211022
De Petrocellis L et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. 2011 Br. J. Pharmacol. pmid:21175579
Petrosino S et al. Alteration of the endocannabinoid system in mouse brain during prion disease. 2011 Neuroscience pmid:21195746
Jumpertz R et al. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. 2011 J. Clin. Endocrinol. Metab. pmid:21177788
Sciolino NR et al. Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. 2011 Pharmacol. Res. pmid:21600985
Uchigashima M et al. Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. 2011 J. Neurosci. pmid:21613483
Di Marzo V Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. 2011 Nat. Neurosci. pmid:21187849
Alhouayek M et al. Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. 2011 FASEB J. pmid:21551239
Justinová Z et al. The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. 2011 J. Neurosci. pmid:21562266
Guindon J et al. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. 2011 Br. J. Pharmacol. pmid:21198549
Borges BC et al. Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21343543
Shekhar C Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. 2011 Chem. Biol. pmid:21609833
Ho YC et al. Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. 2011 J. Neurosci. pmid:21994376
Quercioli A et al. Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. 2011 Eur. Heart J. pmid:21303779
Cippitelli A et al. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. 2011 PLoS ONE pmid:22140525
Brizzi A et al. Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. 2011 J. Med. Chem. pmid:22044209
Yoshino H et al. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. 2011 J. Physiol. (Lond.) pmid:21807615
Chouinard F et al. The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. 2011 J. Immunol. pmid:21278347
Khasabova IA et al. Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. 2011 Pharmacol. Res. pmid:21440630
Catanzaro G et al. Effect of capacitation on the endocannabinoid system of mouse sperm. 2011 Mol. Cell. Endocrinol. pmid:21723369
Ueda N et al. Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. 2011 Jan-Feb Biofactors pmid:21328621
Haas MJ et al. Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. 2012 Obesity (Silver Spring) pmid:22016100
Forsell PK et al. Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. 2012 Lipids pmid:22684912
Wang M et al. Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. 2012 J. Psychopharmacol. (Oxford) pmid:21890595
Oleson EB et al. Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. 2012 Neuron pmid:22284189
Mimura T et al. Involvement of the endogenous cannabinoid 2 ligand 2-arachidonyl glycerol in allergic inflammation. 2012 Int. Arch. Allergy Immunol. pmid:22652530
Luchicchi A and Pistis M Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. 2012 Mol. Neurobiol. pmid:22801993
Jung KM et al. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. 2012 Cell Metab. pmid:22405068
Xu JY et al. Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids. 2012 J. Physiol. (Lond.) pmid:22411015
Echigo R et al. Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells. 2012 Oncol. Rep. pmid:22842590
Petrovszki Z et al. The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level. 2012 Anesth. Analg. pmid:22451592
Monteleone P et al. Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. 2012 J. Clin. Endocrinol. Metab. pmid:22442280
Tsumura M et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. 2012 Cell Calcium pmid:22656960
Reisenberg M et al. The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108545
Melis M and Pistis M Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108546
Chanda D et al. Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. 2012 J. Biol. Chem. pmid:22989885
Strewe C et al. Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. 2012 Rev Neurosci pmid:23023882