2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Hepatic Encephalopathy D006501 9 associated lipids
Weight Gain D015430 101 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Glioma D005910 112 associated lipids
Obesity D009765 29 associated lipids
Alzheimer Disease D000544 76 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Nervous System Diseases D009422 37 associated lipids
Brain Edema D001929 20 associated lipids
Starvation D013217 47 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Prusakiewicz JJ et al. Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. 2009 Biochemistry pmid:19603831
Astarita G et al. Targeted lipidomics as a tool to investigate endocannabinoid function. 2009 Int. Rev. Neurobiol. pmid:19607960
Morgan NH et al. Functional CB2 type cannabinoid receptors at CNS synapses. 2009 Neuropharmacology pmid:19616018
Amorós I et al. Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. 2010 J. Mol. Cell. Cardiol. pmid:19616555
Tsuyama S et al. Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. 2009 Nutr Neurosci pmid:19622239
Long JZ et al. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. 2009 Chem. Biol. pmid:19635411
Alvarez-Jaimes L et al. Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. 2009 J. Neurochem. pmid:19650871
Li Q and Burrell BD Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. 2009 J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. pmid:19657662
Lane JR et al. The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor. 2010 Biochem. Pharmacol. pmid:19665453
Pan B et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. 2009 J. Pharmacol. Exp. Ther. pmid:19666749
Patel S et al. Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. 2009 Neuropsychopharmacology pmid:19675536
Duclos RI The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1'-(13)C3 and -2,1'-(13)C2 by a novel chemoenzymatic method. 2010 Chem. Phys. Lipids pmid:19682980
Thors L and Fowler CJ Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. 2009 Eur. J. Pharmacol. pmid:19715690
Di Marzo V et al. Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. 2009 Eur. J. Endocrinol. pmid:19745037
Schroeder C et al. Circulating endocannabinoid concentrations during orthostatic stress. 2009 Clin. Auton. Res. pmid:19756829
Avraham Y et al. Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. 2009 Br. J. Pharmacol. pmid:19764982
Straiker A et al. Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. 2009 Mol. Pharmacol. pmid:19767452
Piccinetti CC et al. Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. 2010 Gen. Comp. Endocrinol. pmid:19800340
Gkini E et al. Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. 2009 Platelets pmid:19811221
Cobellis G et al. A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. 2010 Biol. Reprod. pmid:19812302
Romigi A et al. Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. 2010 Epilepsia pmid:19817812
Maison P et al. BDNF regulates neuronal sensitivity to endocannabinoids. 2009 Neurosci. Lett. pmid:19818836
Guindon J and Hohmann AG The endocannabinoid system and pain. 2009 CNS Neurol Disord Drug Targets pmid:19839937
Caraceni P et al. Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. 2010 Liver Int. pmid:19840245
Zhang SY et al. Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 2009 J. Neurosci. pmid:19846710
Won YJ et al. Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. 2009 J. Neurosci. pmid:19864572
Telleria-Diaz A et al. Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. 2010 Pain pmid:19879047
Bradshaw H CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. 2010 Pain pmid:19913999
Long JZ et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19918051
Marco EM and Viveros MP The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. 2009 Mini Rev Med Chem pmid:19929814
Weis F et al. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. 2010 J. Mol. Cell. Cardiol. pmid:19931541
Zhang MY et al. Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. 2010 J Mass Spectrom pmid:19950120
Labar G et al. Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. 2010 Chembiochem pmid:19957260
Banni S and Di Marzo V Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. 2010 Mol Nutr Food Res pmid:20013888
Eisenstein SA et al. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. 2010 Pharmacol. Res. pmid:20044005
Sang N et al. Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. 2010 Neurochem. Int. pmid:20064571
Lourenço J et al. Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. 2010 Nat. Neurosci. pmid:20081851
Carrasquer A et al. Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor. 2010 Pharmacogenet. Genomics pmid:20124950
Guida M et al. The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. 2010 Endocrinology pmid:20133454
Casida JE et al. S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. 2010 Bioorg. Med. Chem. pmid:20138526
Gao Y et al. Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. 2010 J. Neurosci. pmid:20147530
Lerner TN et al. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. 2010 J. Neurosci. pmid:20147543
Arevalo-Martin A et al. The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. 2010 Neurobiol. Dis. pmid:20156559
Best AR and Regehr WG Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. 2010 Neuron pmid:20159441
Yasuo S et al. An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. 2010 Cell Tissue Res. pmid:20165884
Reggio PH Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. 2010 Curr. Med. Chem. pmid:20166921
Musella A et al. Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. 2010 Neuroscience pmid:20219639
Hurst DP et al. A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. 2010 J. Biol. Chem. pmid:20220143
Kozono S et al. Involvement of the endocannabinoid system in periodontal healing. 2010 Biochem. Biophys. Res. Commun. pmid:20233580
Muccioli GG Endocannabinoid biosynthesis and inactivation, from simple to complex. 2010 Drug Discov. Today pmid:20304091