Kirkham TC et al. |
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. |
2002 |
Br. J. Pharmacol. |
pmid:12055133
|
Ryberg E et al. |
The orphan receptor GPR55 is a novel cannabinoid receptor. |
2007 |
Br. J. Pharmacol. |
pmid:17876302
|
Straiker A et al. |
Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones. |
2012 |
Br. J. Pharmacol. |
pmid:22014238
|
Woodhams SG et al. |
Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. |
2012 |
Br. J. Pharmacol. |
pmid:22924700
|
Du H et al. |
Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. |
2011 |
Br. J. Pharmacol. |
pmid:21501147
|
Rimmerman N et al. |
Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. |
2008 |
Br. J. Pharmacol. |
pmid:17965731
|
Hohmann AG |
Inhibitors of monoacylglycerol lipase as novel analgesics. |
2007 |
Br. J. Pharmacol. |
pmid:17293886
|
Chicca A et al. |
The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. |
2012 |
Br. J. Pharmacol. |
pmid:22646533
|
Ho WS and Randall MD |
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. |
2007 |
Br. J. Pharmacol. |
pmid:17245358
|
Booker L et al. |
The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. |
2012 |
Br. J. Pharmacol. |
pmid:21506952
|
Mukhopadhyay P et al. |
CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. |
2010 |
Br. J. Pharmacol. |
pmid:20590569
|
Gutierrez-Lopez MD et al. |
Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. |
2010 |
Br. J. Pharmacol. |
pmid:20590579
|
Solinas M et al. |
The endocannabinoid system in brain reward processes. |
2008 |
Br. J. Pharmacol. |
pmid:18414385
|
Sticht MA et al. |
Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. |
2012 |
Br. J. Pharmacol. |
pmid:21470205
|
Kerr DM et al. |
The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. |
2013 |
Br. J. Pharmacol. |
pmid:23043675
|
Liao HT et al. |
Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. |
2011 |
Br. J. Pharmacol. |
pmid:21232043
|
De Petrocellis L et al. |
Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. |
2011 |
Br. J. Pharmacol. |
pmid:21175579
|
Guindon J et al. |
Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. |
2011 |
Br. J. Pharmacol. |
pmid:21198549
|
Petrosino S et al. |
The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. |
2016 |
Br. J. Pharmacol. |
pmid:25598150
|
Izzo AA et al. |
Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. |
2009 |
Br. J. Pharmacol. |
pmid:19371345
|
Savinainen JR et al. |
Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes. |
2001 |
Br. J. Pharmacol. |
pmid:11588122
|
Ghafouri N et al. |
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. |
2004 |
Br. J. Pharmacol. |
pmid:15492019
|
Ho WS et al. |
Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. |
2015 |
Br. J. Pharmacol. |
pmid:26294342
|
Pei R et al. |
Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial. |
2017 |
Br. J. Nutr. |
pmid:29179781
|
Morgan CJ et al. |
Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. |
2013 |
Br J Psychiatry |
pmid:23580381
|
Keown OP et al. |
2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. |
2010 |
Br J Clin Pharmacol |
pmid:20653671
|
Valastro C et al. |
Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study. |
2017 |
BMC Vet. Res. |
pmid:29110674
|
Gesell FK et al. |
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. |
2013 |
BMC Vet. Res. |
pmid:24370333
|
Cipriano M et al. |
The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. |
2014 |
BMC Res Notes |
pmid:25012825
|
Soderstrom K et al. |
Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness. |
2011 |
BMC Neurosci |
pmid:21211022
|
Jordà MA et al. |
Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. |
2002 |
Blood |
pmid:11929767
|
Jordà MA et al. |
The peripheral cannabinoid receptor Cb2, a novel oncoprotein, induces a reversible block in neutrophilic differentiation. |
2003 |
Blood |
pmid:12406867
|
Alberich Jordà M et al. |
The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner. |
2004 |
Blood |
pmid:15039279
|
Psychoyos D et al. |
Cannabinoid receptor 1 signaling in embryo neurodevelopment. |
2012 |
Birth Defects Res. B Dev. Reprod. Toxicol. |
pmid:22311661
|
Deng H and van der Stelt M |
Chemical tools to modulate 2-arachidonoylglycerol biosynthesis. |
2018 |
Biotechnol. Appl. Biochem. |
pmid:28589628
|
Abed SM et al. |
Synthesis of 1,3-dioleoyl-2-arachidonoylglycerol-rich structured lipids by lipase-catalyzed acidolysis of microbial oil from Mortierella alpina. |
2017 |
Bioresour. Technol. |
pmid:28688328
|
Nomura DK et al. |
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18752948
|
Vadivel SK et al. |
Conformationally constrained analogues of 2-arachidonoylglycerol. |
2007 |
Bioorg. Med. Chem. Lett. |
pmid:17826996
|
Hoover HS et al. |
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. |
2008 |
Bioorg. Med. Chem. Lett. |
pmid:18657971
|
Parkkari T et al. |
Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability. |
2006 |
Bioorg. Med. Chem. Lett. |
pmid:16466915
|
Suhara Y et al. |
Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. |
2001 |
Bioorg. Med. Chem. Lett. |
pmid:11454463
|
Janssen FJ and van der Stelt M |
Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. |
2016 |
Bioorg. Med. Chem. Lett. |
pmid:27394666
|
Casida JE et al. |
S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. |
2010 |
Bioorg. Med. Chem. |
pmid:20138526
|
Parkkari T et al. |
Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE). |
2006 |
Bioorg. Med. Chem. |
pmid:16403642
|
Suhara Y et al. |
Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. |
2007 |
Bioorg. Med. Chem. |
pmid:17110113
|
Wang X et al. |
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. |
2016 |
Biomed Res Int |
pmid:26904688
|
Spaziano G et al. |
Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. |
2015 |
Biomed Res Int |
pmid:25866824
|
Cobellis G et al. |
A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. |
2010 |
Biol. Reprod. |
pmid:19812302
|
Paria BC et al. |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. |
1998 |
Biol. Reprod. |
pmid:9623610
|
Lu HC and Mackie K |
An Introduction to the Endogenous Cannabinoid System. |
2016 |
Biol. Psychiatry |
pmid:26698193
|
Bedse G et al. |
Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. |
2017 |
Biol. Psychiatry |
pmid:28438413
|
Jenniches I and Zimmer A |
Reply to: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. |
2016 |
Biol. Psychiatry |
pmid:26410564
|
Patel S et al. |
The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. |
2016 |
Biol. Psychiatry |
pmid:26212898
|
Saravia R et al. |
CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. |
2017 |
Biol. Psychiatry |
pmid:27737762
|
Busquets-Garcia A et al. |
Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. |
2011 |
Biol. Psychiatry |
pmid:21684528
|
Volk DW and Lewis DA |
The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. |
2016 |
Biol. Psychiatry |
pmid:26210060
|
Gokoh M et al. |
2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. |
2007 |
Biol. Pharm. Bull. |
pmid:17603153
|
Ueda N et al. |
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. |
2011 Jan-Feb |
Biofactors |
pmid:21328621
|
Pascual AC et al. |
Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. |
2013 Mar-Apr |
Biofactors |
pmid:23281018
|
Sugiura T |
Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. |
2009 Jan-Feb |
Biofactors |
pmid:19319851
|
Signorello MG and Leoncini G |
Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. |
2014 |
Biochimie |
pmid:25068972
|
Spoto B et al. |
Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. |
2006 |
Biochimie |
pmid:16949718
|
Signorello MG et al. |
The 2-arachidonoylglycerol effect on myosin light chain phosphorylation in human platelets. |
2013 |
Biochimie |
pmid:23702422
|
Costa MA et al. |
The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast. |
2016 |
Biochim. Biophys. Acta |
pmid:26698196
|
Basavarajappa BS et al. |
Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons. |
2000 |
Biochim. Biophys. Acta |
pmid:11113634
|
Gantayet A et al. |
Endocannabinoids and diacylglycerol kinase activity. |
2011 |
Biochim. Biophys. Acta |
pmid:21194521
|
Urquhart P et al. |
Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. |
2015 |
Biochim. Biophys. Acta |
pmid:25543004
|
Leishman E et al. |
Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. |
2016 |
Biochim. Biophys. Acta |
pmid:26956082
|
Bisogno T et al. |
Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. |
2009 |
Biochim. Biophys. Acta |
pmid:19027877
|
Di Marzo V |
2-Arachidonoyl-glycerol as an "endocannabinoid": limelight for a formerly neglected metabolite. |
1998 |
Biochemistry Mosc. |
pmid:9526090
|
Martin GG et al. |
Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant. |
2017 |
Biochemistry |
pmid:28853554
|
Moody JS et al. |
Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. |
2001 |
Biochemistry |
pmid:11170406
|
Wang R et al. |
Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. |
2013 |
Biochemistry |
pmid:24083319
|
Prusakiewicz JJ et al. |
Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. |
2009 |
Biochemistry |
pmid:19603831
|
Fowler CJ et al. |
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. |
2001 |
Biochem. Pharmacol. |
pmid:11585048
|
Fowler CJ et al. |
Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. |
2003 |
Biochem. Pharmacol. |
pmid:12948856
|
Goparaju SK et al. |
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors. |
1999 |
Biochem. Pharmacol. |
pmid:9933030
|
Saario SM et al. |
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. |
2004 |
Biochem. Pharmacol. |
pmid:15013854
|
Mechoulam R et al. |
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. |
1995 |
Biochem. Pharmacol. |
pmid:7605349
|
Lane JR et al. |
The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor. |
2010 |
Biochem. Pharmacol. |
pmid:19665453
|
Mestre L et al. |
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection. |
2006 |
Biochem. Pharmacol. |
pmid:16914119
|
Rockwell CE et al. |
A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. |
2008 |
Biochem. Pharmacol. |
pmid:18571623
|
Gokoh M et al. |
2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. |
2005 |
Biochem. J. |
pmid:15456404
|
Bisogno T et al. |
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells. |
1997 |
Biochem. J. |
pmid:9065792
|
Di Marzo V et al. |
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. |
2001 |
Biochem. J. |
pmid:11485574
|
Di Marzo V et al. |
The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide. |
1998 |
Biochem. J. |
pmid:9512456
|
Siegmund SV et al. |
Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:26801558
|
Spivak CE et al. |
Blockade of β-cell K(ATP) channels by the endocannabinoid, 2-arachidonoylglycerol. |
2012 |
Biochem. Biophys. Res. Commun. |
pmid:22609205
|
Sugiura T et al. |
Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10814517
|
Bisogno T et al. |
Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function. |
1999 |
Biochem. Biophys. Res. Commun. |
pmid:10079192
|
Siegmund SV et al. |
Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23806692
|
Kozono S et al. |
Involvement of the endocannabinoid system in periodontal healing. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20233580
|
Sugiura T et al. |
2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. |
1995 |
Biochem. Biophys. Res. Commun. |
pmid:7575630
|
Chen J et al. |
Finding of endocannabinoids in human eye tissues: implications for glaucoma. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15823551
|
Maccarrone M et al. |
Anandamide and 2-arachidonoylglycerol inhibit fatty acid amide hydrolase by activating the lipoxygenase pathway of the arachidonate cascade. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:11095952
|
Di Marzo V et al. |
Potential biosynthetic connections between the two cannabimimetic eicosanoids, anandamide and 2-arachidonoyl-glycerol, in mouse neuroblastoma cells. |
1996 |
Biochem. Biophys. Res. Commun. |
pmid:8858137
|
Nithipatikom K et al. |
A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. |
2005 |
Biochem. Biophys. Res. Commun. |
pmid:15919052
|
Sugiura T et al. |
Inhibition by 2-arachidonoylglycerol, a novel type of possible neuromodulator, of the depolarization-induced increase in intracellular free calcium in neuroblastoma x glioma hybrid NG108-15 cells. |
1997 |
Biochem. Biophys. Res. Commun. |
pmid:9144424
|
Sugiura T et al. |
Detection of an endogenous cannabimimetic molecule, 2-arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: is 2-arachidonoylglycerol a possible vasomodulator? |
1998 |
Biochem. Biophys. Res. Commun. |
pmid:9501013
|
González S et al. |
Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland. |
2000 |
Biochem. Biophys. Res. Commun. |
pmid:10733937
|