| MeSH term | MeSH ID | Detail |
|---|---|---|
| Head Injuries, Closed | D016489 | 5 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Ganglion Cysts | D045888 | 1 associated lipids |
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Acute Pain | D059787 | 3 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baggelaar MP et al. | Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:24173880 |
| Ueda N et al. | Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. | 2013 | FEBS J. | pmid:23425575 |
| Sugaya Y et al. | The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. | 2013 | J. Neurosci. | pmid:23426686 |
| DiPatrizio NV et al. | Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. | 2013 | FASEB J. | pmid:23463697 |
| Yuan S and Burrell BD | Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation. | 2013 | J. Neurosci. | pmid:23467351 |
| Kinsey SG et al. | Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23412396 |
| Almeida-Santos AF et al. | Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray. | 2013 | Behav. Brain Res. | pmid:23714073 |
| Perez-Rosello T et al. | Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. | 2013 | J. Neurosci. | pmid:23719795 |
| Yang Y et al. | Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. | 2013 | Cell. Signal. | pmid:23142606 |
| Sticht MA et al. | 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. | 2013 | Physiol. Behav. | pmid:23958470 |
| Guindon J et al. | Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. | 2013 | Pharmacol. Res. | pmid:23127915 |
| Blankman JL and Cravatt BF | Chemical probes of endocannabinoid metabolism. | 2013 | Pharmacol. Rev. | pmid:23512546 |
| Carr RL et al. | Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure. | 2013 | Toxicol. Sci. | pmid:23761300 |
| Blasio A et al. | Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. | 2013 | Neuropsychopharmacology | pmid:23793355 |
| Feuerecker M et al. | Effect of an acute consumption of a moderate amount of ethanol on plasma endocannabinoid levels in humans. | 2012 May-Jun | Alcohol Alcohol. | pmid:22278319 |
| Chang JW et al. | Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. | 2012 | Chem. Biol. | pmid:22542104 |
| Atwood BK et al. | CBâ‚‚ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons. | 2012 | Neuropharmacology | pmid:22579668 |
| Chon SH et al. | Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. | 2012 | PLoS ONE | pmid:22937137 |
| Thomas KC et al. | Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21949157 |
| Skaper SD and Di Marzo V | Endocannabinoids in nervous system health and disease: the big picture in a nutshell. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108539 |