| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Neuromyelitis Optica | D009471 | 2 associated lipids |
| Acute Pain | D059787 | 3 associated lipids |
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
| Ganglion Cysts | D045888 | 1 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nithipatikom K et al. | A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. | 2014 | J. Lipid Res. | pmid:24958911 |
| Karabowicz P et al. | [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. | 2014 | Postepy Hig Med Dosw (Online) | pmid:24934539 |
| Hillard CJ | Stress regulates endocannabinoid-CB1 receptor signaling. | 2014 | Semin. Immunol. | pmid:24882055 |
| Lu Y et al. | Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. | 2014 | J. Mol. Neurosci. | pmid:24510751 |
| Lau BK et al. | Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. | 2014 | Br. J. Pharmacol. | pmid:25041240 |
| Laprairie RB et al. | Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. | 2014 | J. Biol. Chem. | pmid:25037227 |
| Cipriano M et al. | The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. | 2014 | BMC Res Notes | pmid:25012825 |
| Larose MC et al. | Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. | 2014 | J. Allergy Clin. Immunol. | pmid:24530098 |
| Abdulnour J et al. | Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. | 2014 | Obesity (Silver Spring) | pmid:23616305 |
| Melis M et al. | Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. | 2014 | J. Neurosci. | pmid:25232109 |
| Murataeva N et al. | Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. | 2014 | Br. J. Pharmacol. | pmid:24102242 |
| Yasuo S et al. | 2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters. | 2014 | Chronobiol. Int. | pmid:24200164 |
| Pulgar VM et al. | Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. | 2014 | Hypertension | pmid:24935942 |
| Fowler CJ | Has FLAT fallen flat? | 2014 | Trends Pharmacol. Sci. | pmid:24398120 |
| Rea K et al. | Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. | 2014 | Eur. J. Neurosci. | pmid:24494683 |
| Zheng Y et al. | Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. | 2014 | Eur. J. Pharmacol. | pmid:24508383 |
| Krishnan G and Chatterjee N | Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. | 2014 | Mol. Cell. Neurosci. | pmid:24418364 |
| Nicolussi S et al. | Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. | 2014 | Pharmacol. Res. | pmid:24412246 |
| Bystrowska B et al. | Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training. | 2014 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:24334211 |
| Alpár A et al. | Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | 2014 | Nat Commun | pmid:25030704 |