2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Epilepsy D004827 35 associated lipids
Nerve Degeneration D009410 53 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Morphine Dependence D009021 9 associated lipids
Catalepsy D002375 30 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
pmid:
Bisogno T et al. Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function. 1999 Biochem. Biophys. Res. Commun. pmid:10079192
Self DW Anandamide: a candidate neurotransmitter heads for the big leagues. 1999 Nat. Neurosci. pmid:10204533
Giuffrida A et al. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. 1999 Nat. Neurosci. pmid:10204543
Bisogno T et al. Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin. 1999 J. Neurochem. pmid:10217292
Piomelli D et al. Structural determinants for recognition and translocation by the anandamide transporter. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10318965
Sugiura T et al. [2-Arachidonoylglycerol: an endogenous cannabinoid receptor agonist]. 1999 Tanpakushitsu Kakusan Koso pmid:10396990
Di Marzo V et al. Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments. 1999 Lipids pmid:10419192
Di Marzo V et al. Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. 1999 Eur. J. Biochem. pmid:10447696
Martin BR et al. Discovery and characterization of endogenous cannabinoids. 1999 Life Sci. pmid:10462059
Di Marzo V Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators. 1999 Life Sci. pmid:10462065
Bisogno T et al. Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina. 1999 Arch. Biochem. Biophys. pmid:10577359
Melck D et al. Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. 2000 Endocrinology pmid:10614630
Sugiura T et al. Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. 2000 J. Biol. Chem. pmid:10617657
Sinor AD et al. Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. 2000 Neurosci. Lett. pmid:10653017
Schmid PC et al. A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols. 2000 Chem. Phys. Lipids pmid:10669310
Járai Z et al. Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice. 2000 Hypertension pmid:10679517
Ameri A and Simmet T Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices. 2000 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10731038
González S et al. Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland. 2000 Biochem. Biophys. Res. Commun. pmid:10733937
Gonsiorek W et al. Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. 2000 Mol. Pharmacol. pmid:10779390
Hillard CJ Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. 2000 Prostaglandins Other Lipid Mediat. pmid:10785538
Di Marzo V et al. Cannabimimetic fatty acid derivatives in cancer and inflammation. 2000 Prostaglandins Other Lipid Mediat. pmid:10785541
Kunos G et al. Cardiovascular effects of endocannabinoids--the plot thickens. 2000 Prostaglandins Other Lipid Mediat. pmid:10785543
Sugiura T et al. Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. 2000 Biochem. Biophys. Res. Commun. pmid:10814517
Beltramo M and Piomelli D Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. 2000 Neuroreport pmid:10817598
Sugiura T and Waku K 2-arachidonoylglycerol: a possible multifunctional lipid mediator in the nervous and immune systems. 2000 Ann. N. Y. Acad. Sci. pmid:10818479
Jarrahian A et al. Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. 2000 J. Neurochem. pmid:10820223
Hillard CJ Endocannabinoids and vascular function. 2000 J. Pharmacol. Exp. Ther. pmid:10871291
Di Marzo V et al. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. 2000 FASEB J. pmid:10877836
Suhara Y et al. Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues. 2000 Chem. Pharm. Bull. pmid:10923815
Kozak KR et al. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. 2000 J. Biol. Chem. pmid:10931854
Martin BR et al. Cannabinoid properties of methylfluorophosphonate analogs. 2000 J. Pharmacol. Exp. Ther. pmid:10945879
Chen Y et al. Human brain capillary endothelium: 2-arachidonoglycerol (endocannabinoid) interacts with endothelin-1. 2000 Circ. Res. pmid:10948067
Stefano GB et al. 2-arachidonyl-glycerol stimulates nitric oxide release from human immune and vascular tissues and invertebrate immunocytes by cannabinoid receptor 1. 2000 Pharmacol. Res. pmid:10987990
Szallasi A and Di Marzo V New perspectives on enigmatic vanilloid receptors. 2000 Trends Neurosci. pmid:11006466
Gallily R et al. 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice. 2000 Eur. J. Pharmacol. pmid:11011050
Di Marzo V et al. Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. 2000 Eur. J. Pharmacol. pmid:11040343
Di Marzo V et al. Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. 2000 J. Neurochem. pmid:11080195
Rhee MH et al. Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor. 2000 J. Neurochem. pmid:11080201
Pryor SR Is platelet release of 2-arachidonoyl-glycerol a mediator of cognitive deficits? An endocannabinoid theory of schizophrenia and arousal. 2000 Med. Hypotheses pmid:11090297
Maccarrone M et al. Anandamide and 2-arachidonoylglycerol inhibit fatty acid amide hydrolase by activating the lipoxygenase pathway of the arachidonate cascade. 2000 Biochem. Biophys. Res. Commun. pmid:11095952
Calignano A et al. A role for the endogenous cannabinoid system in the peripheral control of pain initiation. 2000 Prog. Brain Res. pmid:11098711
Howlett AC and Mukhopadhyay S Cellular signal transduction by anandamide and 2-arachidonoylglycerol. 2000 Chem. Phys. Lipids pmid:11106782
Sugiura T and Waku K 2-Arachidonoylglycerol and the cannabinoid receptors. 2000 Chem. Phys. Lipids pmid:11106784
Basavarajappa BS et al. Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons. 2000 Biochim. Biophys. Acta pmid:11113634
Sugiura T et al. Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation. 2001 Neurosci. Lett. pmid:11137756
Baker D et al. Endocannabinoids control spasticity in a multiple sclerosis model. 2001 FASEB J. pmid:11156943
MacCarrone M et al. Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. 2001 Eur. J. Biochem. pmid:11168423
Moody JS et al. Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. 2001 Biochemistry pmid:11170406
Huang SM et al. Liquid chromatographic-mass spectrometric measurement of the endogenous cannabinoid 2-arachidonylglycerol in the spinal cord and peripheral nervous system. 1999 Zhongguo Yao Li Xue Bao pmid:11189199