2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Neuromyelitis Optica D009471 2 associated lipids
Obesity D009765 29 associated lipids
Pain D010146 64 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Starvation D013217 47 associated lipids
Stomach Ulcer D013276 75 associated lipids
Reperfusion Injury D015427 65 associated lipids
Myocardial Reperfusion Injury D015428 20 associated lipids
Weight Gain D015430 101 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Hutchins-Wiese HL et al. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. 2012 J. Nutr. Biochem. pmid:22051448
Haas MJ et al. Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. 2012 Obesity (Silver Spring) pmid:22016100
Heyman E et al. Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. 2012 Psychoneuroendocrinology pmid:22029953
Chang JW et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. 2012 Chem. Biol. pmid:22542104
Forsell PK et al. Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. 2012 Lipids pmid:22684912
Atwood BK et al. CBâ‚‚ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons. 2012 Neuropharmacology pmid:22579668
Spivak CE et al. Blockade of β-cell K(ATP) channels by the endocannabinoid, 2-arachidonoylglycerol. 2012 Biochem. Biophys. Res. Commun. pmid:22609205
Straiker A et al. Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones. 2012 Br. J. Pharmacol. pmid:22014238
Battista N et al. The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. 2012 Mol. Cell. Endocrinol. pmid:22305972
Atsak P et al. Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22331883
Chon SH et al. Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. 2012 PLoS ONE pmid:22937137
Musee J and Marnett LJ Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid. 2012 J. Biol. Chem. pmid:22942274
Wang DJ et al. Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. 2012 PLoS ONE pmid:22927908
Wang PF et al. Cannabinoid-2 receptor activation protects against infarct and ischemia-reperfusion heart injury. 2012 J. Cardiovasc. Pharmacol. pmid:22113346
Fanelli F et al. Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS. 2012 J. Lipid Res. pmid:22172516
Roberts CJ et al. Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. 2012 Neuroscience pmid:22192839
Alhouayek M and Muccioli GG The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. 2012 Trends Mol Med pmid:22917662
Thomas KC et al. Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. 2012 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21949157
Woodhams SG et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. 2012 Br. J. Pharmacol. pmid:22924700
Schulte K et al. Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. 2012 Naunyn Schmiedebergs Arch. Pharmacol. pmid:22215206
Wu X et al. Alteration of endocannabinoid system in human gliomas. 2012 J. Neurochem. pmid:22176552
Wang M et al. Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. 2012 J. Psychopharmacol. (Oxford) pmid:21890595
Savinainen JR et al. The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors. 2012 Acta Physiol (Oxf) pmid:21418147
Gatta-Cherifi B et al. Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. 2012 Int J Obes (Lond) pmid:21844878
Oleson EB et al. Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. 2012 Neuron pmid:22284189
Mimura T et al. Involvement of the endogenous cannabinoid 2 ligand 2-arachidonyl glycerol in allergic inflammation. 2012 Int. Arch. Allergy Immunol. pmid:22652530
Luchicchi A and Pistis M Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. 2012 Mol. Neurobiol. pmid:22801993
Jung KM et al. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. 2012 Cell Metab. pmid:22405068
Krishnan G and Chatterjee N Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. 2012 Glia pmid:22807196
Xu JY et al. Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids. 2012 J. Physiol. (Lond.) pmid:22411015
Echigo R et al. Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells. 2012 Oncol. Rep. pmid:22842590
Kortleven C et al. Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG. 2012 Neuropharmacology pmid:22884466
Petrovszki Z et al. The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level. 2012 Anesth. Analg. pmid:22451592
Czifra G et al. Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. 2012 J. Invest. Dermatol. pmid:22513781
Tanimura A et al. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22783023
Caprioli A et al. The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. 2012 J. Pharmacol. Exp. Ther. pmid:22514334
Dubreucq S et al. Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. 2012 Neuropsychopharmacology pmid:22434220
Pucci M et al. Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. 2012 J. Biol. Chem. pmid:22431736
McLaughlin RJ et al. Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. 2012 Eur Neuropsychopharmacol pmid:22325231
Monteleone P et al. Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. 2012 J. Clin. Endocrinol. Metab. pmid:22442280
Tsumura M et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. 2012 Cell Calcium pmid:22656960
Lara-Celador I et al. Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats. 2012 Brain Res. pmid:22841538
Kallendrusch S et al. Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. 2012 PLoS ONE pmid:23284665
Hsu KL et al. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. 2012 Nat. Chem. Biol. pmid:23103940
Reisenberg M et al. The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108545
Melis M and Pistis M Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108546
Chanda D et al. Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. 2012 J. Biol. Chem. pmid:22989885
Strewe C et al. Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. 2012 Rev Neurosci pmid:23023882
Whyte LS et al. Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. 2012 Br. J. Pharmacol. pmid:21649637
Skaper SD and Di Marzo V Endocannabinoids in nervous system health and disease: the big picture in a nutshell. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108539
Booker L et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. 2012 Br. J. Pharmacol. pmid:21506952
Di Marzo V and De Petrocellis L Why do cannabinoid receptors have more than one endogenous ligand? 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108541
Puighermanal E et al. Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108544
Starowicz K and Przewlocka B Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108547
Rani Sagar D et al. Dynamic changes to the endocannabinoid system in models of chronic pain. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108548
Sticht MA et al. Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. 2012 Br. J. Pharmacol. pmid:21470205
Jones BR et al. Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules. 2012 Bioanalysis pmid:23088461
Hauer D et al. Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. 2012 Rev Neurosci pmid:23006898
Gyombolai P et al. Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. 2012 Mol. Cell. Endocrinol. pmid:22075205
Song J et al. Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. 2012 J. Neurosci. pmid:22496555
Psychoyos D et al. Cannabinoid receptor 1 signaling in embryo neurodevelopment. 2012 Birth Defects Res. B Dev. Reprod. Toxicol. pmid:22311661
Navia-Paldanius D et al. Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). 2012 J. Lipid Res. pmid:22969151
Zoerner AA et al. Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21752730
Alger BE Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): what we still do not know. 2012 J. Physiol. (Lond.) pmid:22289914
Katona I and Freund TF Multiple functions of endocannabinoid signaling in the brain. 2012 Annu. Rev. Neurosci. pmid:22524785
Feuerecker M et al. Effect of an acute consumption of a moderate amount of ethanol on plasma endocannabinoid levels in humans. 2012 May-Jun Alcohol Alcohol. pmid:22278319
Fagundo AB et al. Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. 2013 PLoS ONE pmid:23840456
Sergi M et al. Determination of the two major endocannabinoids in human plasma by μ-SPE followed by HPLC-MS/MS. 2013 Anal Bioanal Chem pmid:22847477
Ueda N et al. Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways. 2013 FEBS J. pmid:23425575
Sugaya Y et al. The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. 2013 J. Neurosci. pmid:23426686
DiPatrizio NV et al. Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. 2013 FASEB J. pmid:23463697
Chiou LC et al. Targeting the cannabinoid system for pain relief? 2013 Acta Anaesthesiol Taiwan pmid:24529672
Valdeolivas S et al. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. 2013 Cell Death Dis pmid:24136226
Jäntti MH et al. Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. 2013 Mol. Pharmacol. pmid:23233488
Su LD et al. Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. 2013 Cerebellum pmid:23307660
Keimpema E et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23319656
Shimizu T et al. Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. 2013 J. Pharmacol. Sci. pmid:23386378
Tchantchou F and Zhang Y Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. 2013 J. Neurotrauma pmid:23151067
Alhouayek M et al. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24101490
Iannotti FA et al. Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23830028
Neumeister A et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. 2013 Mol. Psychiatry pmid:23670490
Citraro R et al. Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. 2013 Neuropharmacology pmid:23206503
Hashimotodani Y et al. Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. 2013 J. Physiol. (Lond.) pmid:23858009
Kerr DM et al. The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. 2013 Br. J. Pharmacol. pmid:23043675
Lindgren CA et al. Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. 2013 J. Physiol. (Lond.) pmid:23818695
Frazier CJ Preformed vs. on-demand: molecular economics of endocannabinoid signalling. 2013 J. Physiol. (Lond.) pmid:24085490
Descalzi F et al. Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. 2013 Tissue Eng Part A pmid:23578218
Bisogno T et al. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. 2013 Br. J. Pharmacol. pmid:23072382
Berge K et al. Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. 2013 Lipids Health Dis pmid:23706001
Zygmunt PM et al. Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. 2013 PLoS ONE pmid:24312564
Wang R et al. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. 2013 Biochemistry pmid:24083319
Ikeda H et al. Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. 2013 Neuroscience pmid:23892011
Ilayan E et al. Do cannabinoids exhibit a tyramine-like effect? 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23900610
Krumbholz A et al. Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. 2013 Ther Drug Monit pmid:23942543
Hill MN et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. 2013 Psychoneuroendocrinology pmid:24035186
Bernabò N et al. Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. 2013 OMICS pmid:24117401
Gesell FK et al. Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. 2013 BMC Vet. Res. pmid:24370333
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
Malenczyk K et al. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. 2013 J. Biol. Chem. pmid:24089517
Brocato B et al. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. 2013 Placenta pmid:24008071