| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperkinesis | D006948 | 11 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Fatty Liver, Alcoholic | D005235 | 11 associated lipids |
| Hypothermia | D007035 | 19 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Head Injuries, Closed | D016489 | 5 associated lipids |
| Brain Concussion | D001924 | 5 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
| Cobellis G et al. | A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. | 2010 | Biol. Reprod. | pmid:19812302 |
| Yasuo S et al. | Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man. | 2010 | Cell Tissue Res. | pmid:20957495 |
| Arevalo-Martin A et al. | The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. | 2010 | Neurobiol. Dis. | pmid:20156559 |
| Eisenstein SA et al. | A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. | 2010 | Pharmacol. Res. | pmid:20044005 |
| Frampton G et al. | Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. | 2010 | Exp. Cell Res. | pmid:20347808 |
| Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
| Hoot MR et al. | Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | 2010 | Brain Res. | pmid:20380816 |
| Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
| Caraceni P et al. | Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. | 2010 | Liver Int. | pmid:19840245 |
| Sagar DR et al. | Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. | 2010 | Arthritis Rheum. | pmid:20722027 |
| Jiang S et al. | Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. | 2010 | J. Biol. Chem. | pmid:20826813 |
| Piccinetti CC et al. | Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. | 2010 | Gen. Comp. Endocrinol. | pmid:19800340 |
| Xie S et al. | Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. | 2010 | Chem. Res. Toxicol. | pmid:21049984 |
| Banni S and Di Marzo V | Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. | 2010 | Mol Nutr Food Res | pmid:20013888 |
| Fonseca BM et al. | The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: a role in uterine remodelling. | 2010 | Int. J. Biochem. Cell Biol. | pmid:20727980 |
| Ying-Ying Y and Lin HC | Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. | 2010 | Liver Int. | pmid:20408944 |
| Spradley JM et al. | Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | 2010 | Pharmacol. Res. | pmid:20416378 |
| Placzek EA et al. | Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). | 2010 | J Pharm Biomed Anal | pmid:20417049 |
| Massa F et al. | Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. | 2010 | J. Neurosci. | pmid:20445053 |
| Bardell TK and Barker EL | Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells. | 2010 | Neurochem. Int. | pmid:20466028 |
| Naccarato M et al. | Possible Anandamide and Palmitoylethanolamide involvement in human stroke. | 2010 | Lipids Health Dis | pmid:20470384 |
| Muccioli GG | Endocannabinoid biosynthesis and inactivation, from simple to complex. | 2010 | Drug Discov. Today | pmid:20304091 |
| Kozono S et al. | Involvement of the endocannabinoid system in periodontal healing. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20233580 |
| Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. | 2010 | Br. J. Pharmacol. | pmid:20590569 |
| Gutierrez-Lopez MD et al. | Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. | 2010 | Br. J. Pharmacol. | pmid:20590579 |
| Muccioli GG et al. | The endocannabinoid system links gut microbiota to adipogenesis. | 2010 | Mol. Syst. Biol. | pmid:20664638 |
| Suárez J et al. | Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. | 2010 | J. Comp. Neurol. | pmid:20533360 |
| Jumpertz R et al. | Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea--specific role of oleoylethanolamide. | 2010 | Exp. Clin. Endocrinol. Diabetes | pmid:20429051 |
| Lerner TN et al. | Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 | J. Neurosci. | pmid:20147543 |
| Reggio PH | Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | 2010 | Curr. Med. Chem. | pmid:20166921 |
| Higuchi S et al. | Reducing acyl migration during purification of 2-arachidonoylglycerol from biological samples before gas chromatography mass spectrometry analysis. | 2010 | Anal Sci | pmid:21079352 |
| Evagorou A et al. | Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme. | 2010 | Eur. J. Protistol. | pmid:20889319 |
| Weis F et al. | Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. | 2010 | J. Mol. Cell. Cardiol. | pmid:19931541 |
| Sang N et al. | Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. | 2010 | Neurochem. Int. | pmid:20064571 |
| Ishii Y et al. | F2-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia/reperfusion injury. | 2010 | J. Surg. Res. | pmid:19439322 |
| Minkkilä A et al. | Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. | 2010 | Curr Top Med Chem | pmid:20370710 |
| Kvasnicka T | [The endocannabinoid system and interference with thrombogenesis]. | 2010 | Vnitr Lek | pmid:20329583 |
| Maccarrone M et al. | Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. | 2010 | Neuropsychopharmacology | pmid:20393458 |
| Hurst DP et al. | A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. | 2010 | J. Biol. Chem. | pmid:20220143 |
| Telleria-Diaz A et al. | Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. | 2010 | Pain | pmid:19879047 |
| Bradshaw H | CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. | 2010 | Pain | pmid:19913999 |
| Zhang MY et al. | Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. | 2010 | J Mass Spectrom | pmid:19950120 |
| Labar G et al. | Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. | 2010 | Chembiochem | pmid:19957260 |
| Jyotaki M et al. | Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. | 2010 | Endocr. J. | pmid:20431269 |
| Mukhopadhyay B et al. | Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. | 2010 | J. Biol. Chem. | pmid:20410309 |
| Maccarrone M | Endocannabinoid-binding receptors: old friends and new comers. | 2010 | Curr. Med. Chem. | pmid:20441559 |
| Skonberg C et al. | Pitfalls in the sample preparation and analysis of N-acylethanolamines. | 2010 | J. Lipid Res. | pmid:20447930 |
| Fino E et al. | Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. | 2010 | J. Physiol. (Lond.) | pmid:20603333 |
| Keown OP et al. | 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. | 2010 | Br J Clin Pharmacol | pmid:20653671 |