2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Hyperkinesis D006948 11 associated lipids
Hyperinsulinism D006946 27 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Hypothermia D007035 19 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Brain Concussion D001924 5 associated lipids
Encephalitis D004660 15 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Valastro C et al. Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study. 2017 BMC Vet. Res. pmid:29110674
Artegoitia VM et al. Endocannabinoid concentrations in plasma during the finishing period are associated with feed efficiency and carcass composition of beef cattle. 2017 J. Anim. Sci. pmid:29108057
Wang SL et al. [Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]. 2017 Sheng Li Xue Bao pmid:29063116
Poursharifi P et al. Monoacylglycerol signalling and ABHD6 in health and disease. 2017 Diabetes Obes Metab pmid:28880480
Raff H et al. Increase in the circulating endocannabinoid 2-arachidonoylglycerol is associated with gabapentin use in septic ICU patients. 2017 Endocrine pmid:28875451
Pascual AC et al. 2-Arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals. 2017 Neuroscience pmid:28844762
Xu C et al. Endocannabinoids exert CB receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein. 2017 Mol. Cell. Neurosci. pmid:28733129
Summers T et al. Endocannabinoids Have Opposing Effects On Behavioral Responses To Nociceptive And Non-nociceptive Stimuli. 2017 Sci Rep pmid:28724917
Francou MM et al. Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid. 2017 Histol. Histopathol. pmid:28585678
Chicca A et al. Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:28584105
Brellenthin AG et al. Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. 2017 Med Sci Sports Exerc pmid:28319590
Carr RL et al. Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. 2017 Neurotoxicology pmid:26642910
Pei R et al. Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial. 2017 Br. J. Nutr. pmid:29179781
Kondakala S et al. Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. 2017 Toxicol. Appl. Pharmacol. pmid:29097212
Zelber-Sagi S et al. Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. 2017 Obesity (Silver Spring) pmid:27863097
Saravia R et al. CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. 2017 Biol. Psychiatry pmid:27737762
Wilkerson JL et al. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. 2017 Neuropharmacology pmid:27890602
Granchi C et al. A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017). 2017 Expert Opin Ther Pat pmid:29053063
Hassanzadeh P et al. Application of carbon nanotubes as the carriers of the cannabinoid, 2-arachidonoylglycerol: Towards a novel treatment strategy in colitis. 2017 Life Sci. pmid:27888115
Barbonetti A et al. 2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages. 2017 Andrology pmid:27863106