| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Brain Concussion | D001924 | 5 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bashashati M et al. | Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. | 2015 | Br. J. Pharmacol. | pmid:25684407 |
| Hillard CJ et al. | Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. | 2007 | Br. J. Pharmacol. | pmid:17891162 |
| Lau BK et al. | Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. | 2014 | Br. J. Pharmacol. | pmid:25041240 |
| Chicca A et al. | The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. | 2012 | Br. J. Pharmacol. | pmid:22646533 |
| Lépicier P et al. | Endocannabinoids protect the rat isolated heart against ischaemia. | 2003 | Br. J. Pharmacol. | pmid:12813004 |
| Ho WS and Randall MD | Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. | 2007 | Br. J. Pharmacol. | pmid:17245358 |
| Whyte LS et al. | Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. | 2012 | Br. J. Pharmacol. | pmid:21649637 |
| Guindon J and Hohmann AG | A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. | 2008 | Br. J. Pharmacol. | pmid:18297102 |
| Hu SS et al. | Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. | 2008 | Br. J. Pharmacol. | pmid:18297109 |
| Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
| Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. | 2010 | Br. J. Pharmacol. | pmid:20590569 |
| Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
| Liao HT et al. | Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. | 2011 | Br. J. Pharmacol. | pmid:21232043 |
| Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
| Murataeva N et al. | Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. | 2014 | Br. J. Pharmacol. | pmid:24102242 |
| Avraham Y et al. | Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. | 2009 | Br. J. Pharmacol. | pmid:19764982 |
| Ghafouri N et al. | Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. | 2004 | Br. J. Pharmacol. | pmid:15492019 |
| Guindon J et al. | The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. | 2007 | Br. J. Pharmacol. | pmid:17179944 |
| Ho WS et al. | Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. | 2015 | Br. J. Pharmacol. | pmid:26294342 |
| Soria-Gómez E et al. | Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. | 2007 | Br. J. Pharmacol. | pmid:17549045 |