2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Neuralgia D009437 28 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Acute Pain D059787 3 associated lipids
Fetal Nutrition Disorders D048070 1 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Blankman JL and Cravatt BF Chemical probes of endocannabinoid metabolism. 2013 Pharmacol. Rev. pmid:23512546
Haruna T et al. The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. 2017 Pharmacology pmid:28214870
Hill MN et al. Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. 2008 Pharmacopsychiatry pmid:18311684
Reisenberg M et al. The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108545
Melis M and Pistis M Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108546
Skaper SD and Di Marzo V Endocannabinoids in nervous system health and disease: the big picture in a nutshell. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108539
Di Marzo V and De Petrocellis L Why do cannabinoid receptors have more than one endogenous ligand? 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108541
Puighermanal E et al. Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108544
Starowicz K and Przewlocka B Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108547
Rani Sagar D et al. Dynamic changes to the endocannabinoid system in models of chronic pain. 2012 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:23108548
Argueta DA and DiPatrizio NV Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity. 2017 Physiol. Behav. pmid:28065722
Thompson Z et al. Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. 2017 Physiol. Behav. pmid:28017680
Sticht MA et al. 2-arachidonoylglycerol interferes with lithium-induced vomiting in the house musk shrew, Suncus murinus. 2013 Physiol. Behav. pmid:23958470
Pacioni G et al. Truffles contain endocannabinoid metabolic enzymes and anandamide. 2015 Phytochemistry pmid:25433633
Brocato B et al. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. 2013 Placenta pmid:24008071
Brantl SA et al. Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. 2014 Platelets pmid:24102401
Brantl SA et al. Mechanism of platelet activation induced by endocannabinoids in blood and plasma. 2014 Platelets pmid:23789792
Gkini E et al. Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. 2009 Platelets pmid:19811221
Jehle J et al. Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. 2018 PLoS ONE pmid:29813086
Martins CJ et al. Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. 2015 PLoS ONE pmid:26561012
Smith M et al. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. 2015 PLoS ONE pmid:26414859
Fagundo AB et al. Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. 2013 PLoS ONE pmid:23840456
Chon SH et al. Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. 2012 PLoS ONE pmid:22937137
Zhang L et al. Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. 2011 PLoS ONE pmid:21305054
Wang DJ et al. Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. 2012 PLoS ONE pmid:22927908
Nicholson J et al. Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. 2015 PLoS ONE pmid:25835291
Higuchi S et al. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. 2012 PLoS ONE pmid:22737214
Özdemir B et al. Endocannabinoids and inflammatory response in periodontal ligament cells. 2014 PLoS ONE pmid:25226300
Kallendrusch S et al. Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. 2012 PLoS ONE pmid:23284665
Lafourcade M et al. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. 2007 PLoS ONE pmid:17684555
Chanda D et al. Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. 2013 PLoS ONE pmid:23894352
Pellkofer HL et al. The major brain endocannabinoid 2-AG controls neuropathic pain and mechanical hyperalgesia in patients with neuromyelitis optica. 2013 PLoS ONE pmid:23951176
Costola-de-Souza C et al. Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice. 2013 PLoS ONE pmid:24204926
Starowicz K et al. Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism. 2013 PLoS ONE pmid:23573230
Zygmunt PM et al. Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. 2013 PLoS ONE pmid:24312564
Pava MJ et al. Endocannabinoid modulation of cortical up-states and NREM sleep. 2014 PLoS ONE pmid:24520411
Cippitelli A et al. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. 2011 PLoS ONE pmid:22140525
Pastor A et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. 2016 PLoS ONE pmid:26849214
Jalin AM et al. Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. 2015 PLoS ONE pmid:26517721
Kita Y et al. Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. 2015 PLoS ONE pmid:26196692
Karabowicz P et al. [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. 2014 Postepy Hig Med Dosw (Online) pmid:24934539
Pertwee RG Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. 2014 Proc Nutr Soc pmid:24135210
Burston JJ and Woodhams SG Endocannabinoid system and pain: an introduction. 2014 Proc Nutr Soc pmid:24148358
Haj-Dahmane S et al. Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. 2018 Proc. Natl. Acad. Sci. U.S.A. pmid:29531087
Atsak P et al. Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22331883
Piomelli D et al. Structural determinants for recognition and translocation by the anandamide transporter. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10318965
Chicca A et al. Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:28584105
Grimaldi P et al. The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19541620
Morena M et al. Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25489086
Tanimura A et al. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22783023
Adermark L and Lovinger DM Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077376
Cristino L et al. Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23630288
Keimpema E et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23319656
Alhouayek M et al. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24101490
Lauckner JE et al. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16365309
Iannotti FA et al. The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:24927567
Yoshida T et al. Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21282604
Witting A et al. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:14976257
Ruby MA et al. Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18794527
Long JZ et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19918051
Buczynski MW et al. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26755579
Ogasawara D et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26668358
Mitchener MM et al. Competition and allostery govern substrate selectivity of cyclooxygenase-2. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26392530
Dinh TP et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12136125
Calignano A et al. A role for the endogenous cannabinoid system in the peripheral control of pain initiation. 2000 Prog. Brain Res. pmid:11098711
Baggelaar MP et al. 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain. 2018 Prog. Lipid Res. pmid:29751000
Iannotti FA et al. Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. 2016 Prog. Lipid Res. pmid:26965148
Sugiura T et al. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. 2006 Prog. Lipid Res. pmid:16678907
Yi B et al. Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors. 2016 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:26780604
Bystrowska B et al. Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training. 2014 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:24334211
Gould GG et al. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. 2012 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:22542870
Avraham Y et al. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. 2008 Jul-Aug Prostaglandins Leukot. Essent. Fatty Acids pmid:18771906
Sugiura T et al. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052034
Fowler CJ and Jacobsson SO Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development? 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052035
Högestätt ED and Zygmunt PM Cardiovascular pharmacology of anandamide. 2002 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:12052048
Watanabe S et al. n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878451
Matias I et al. Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:17011761
Iannotti FA et al. Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23830028
Biernacki M et al. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. 2018 Prostaglandins Other Lipid Mediat. pmid:30201316
Wang J and Ueda N Biology of endocannabinoid synthesis system. 2009 Prostaglandins Other Lipid Mediat. pmid:19126434
Wang H et al. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. 2007 Prostaglandins Other Lipid Mediat. pmid:17259073
Fonseca BM et al. Endogenous cannabinoids revisited: a biochemistry perspective. 2013 Apr-May Prostaglandins Other Lipid Mediat. pmid:23474290
Hillard CJ Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. 2000 Prostaglandins Other Lipid Mediat. pmid:10785538
Di Marzo V et al. Cannabimimetic fatty acid derivatives in cancer and inflammation. 2000 Prostaglandins Other Lipid Mediat. pmid:10785541
Kunos G et al. Cardiovascular effects of endocannabinoids--the plot thickens. 2000 Prostaglandins Other Lipid Mediat. pmid:10785543
Szafran B et al. Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. 2015 Prostaglandins Other Lipid Mediat. pmid:26403860
Basavarajappa BS Critical enzymes involved in endocannabinoid metabolism. 2007 Protein Pept. Lett. pmid:17346227
Schalk-Hihi C et al. Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Ã… resolution. 2011 Protein Sci. pmid:21308848
Coccaro EF et al. Circulating endocannabinoids and affect regulation in human subjects. 2018 Psychoneuroendocrinology pmid:29627714
Heyman E et al. Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. 2012 Psychoneuroendocrinology pmid:22029953
Atsak P et al. Glucocorticoid-endocannabinoid uncoupling mediates fear suppression deficits after early - Life stress. 2018 Psychoneuroendocrinology pmid:29524763
Hill MN et al. Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. 2009 Psychoneuroendocrinology pmid:19394765
Gray JM et al. Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. 2016 Psychoneuroendocrinology pmid:26821211
Hill MN et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. 2013 Psychoneuroendocrinology pmid:24035186
Higgs S et al. Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716. 2003 Psychopharmacology (Berl.) pmid:12447606
Sustkova-Fiserova M et al. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. 2016 Psychopharmacology (Berl.) pmid:26507196
Llorente-Berzal A et al. 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. 2015 Psychopharmacology (Berl.) pmid:25814137
Aliczki M et al. Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. 2015 Psychopharmacology (Berl.) pmid:25547462
Limebeer CL et al. Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. 2014 Psychopharmacology (Berl.) pmid:24043345
McReynolds JR et al. CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. 2016 Psychopharmacology (Berl.) pmid:26455361