| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Neuromyelitis Optica | D009471 | 2 associated lipids |
| Acute Pain | D059787 | 3 associated lipids |
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugiura T and Waku K | 2-arachidonoylglycerol: a possible multifunctional lipid mediator in the nervous and immune systems. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818479 |
| Sinor AD et al. | Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. | 2000 | Neurosci. Lett. | pmid:10653017 |
| Sugiura T et al. | Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814517 |
| Basavarajappa BS et al. | Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons. | 2000 | Biochim. Biophys. Acta | pmid:11113634 |
| Pryor SR | Is platelet release of 2-arachidonoyl-glycerol a mediator of cognitive deficits? An endocannabinoid theory of schizophrenia and arousal. | 2000 | Med. Hypotheses | pmid:11090297 |
| Rhee MH et al. | Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor. | 2000 | J. Neurochem. | pmid:11080201 |
| Sugiura T and Waku K | 2-Arachidonoylglycerol and the cannabinoid receptors. | 2000 | Chem. Phys. Lipids | pmid:11106784 |
| Melck D et al. | Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation. | 2000 | Endocrinology | pmid:10614630 |
| Hillard CJ | Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785538 |
| Di Marzo V et al. | Cannabimimetic fatty acid derivatives in cancer and inflammation. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10785541 |
| Schmid PC et al. | A sensitive endocannabinoid assay. The simultaneous analysis of N-acylethanolamines and 2-monoacylglycerols. | 2000 | Chem. Phys. Lipids | pmid:10669310 |
| González S et al. | Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733937 |
| Maccarrone M et al. | Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. | 2001 | J. Neurochem. | pmid:11461969 |
| Bisogno T et al. | The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors. | 2001 | Eur. J. Biochem. | pmid:11277920 |
| Kobayashi Y et al. | Activation by 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, of p42/44 mitogen-activated protein kinase in HL-60 cells. | 2001 | J. Biochem. | pmid:11328586 |
| Kozak KR et al. | Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol. | 2001 | J. Biol. Chem. | pmid:11402053 |
| Savinainen JR et al. | Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes. | 2001 | Br. J. Pharmacol. | pmid:11588122 |
| Suhara Y et al. | Synthesis and biological activities of novel structural analogues of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11454463 |
| Yamaguchi T et al. | Endogenous cannabinoid, 2-arachidonoylglycerol, attenuates naloxone-precipitated withdrawal signs in morphine-dependent mice. | 2001 | Brain Res. | pmid:11478928 |
| Di Marzo V et al. | Leptin-regulated endocannabinoids are involved in maintaining food intake. | 2001 | Nature | pmid:11298451 |