2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Neurodegenerative Diseases D019636 32 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Neuralgia D009437 28 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Acute Pain D059787 3 associated lipids
Fetal Nutrition Disorders D048070 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Walter L et al. ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. 2004 J. Neurosci. pmid:15371507
Maestroni GJ The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein. 2004 FASEB J. pmid:15385435
Gokoh M et al. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. 2005 Biochem. J. pmid:15456404
Piomelli D The endogenous cannabinoid system and the treatment of marijuana dependence. 2004 Neuropharmacology pmid:15464150
Ghafouri N et al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. 2004 Br. J. Pharmacol. pmid:15492019
Rademacher DJ et al. Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas). 2005 Neurotoxicology pmid:15527869
Gauthier KM et al. Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15528233
Malorni W et al. Morphological evidence that 2-arachidonoylglycerol is a true agonist of human platelets. 2004 Thromb. Haemost. pmid:15543349
Golech SA et al. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. 2004 Brain Res. Mol. Brain Res. pmid:15548432
Mukherjee S et al. Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. 2004 Eur. J. Pharmacol. pmid:15556131
Maccarrone M et al. Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. 2005 Mol. Hum. Reprod. pmid:15563449
Melis M et al. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. 2004 J. Neurosci. pmid:15564588
Sugiura T et al. New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation. 2004 J. Pharmacol. Sci. pmid:15599096
Nithipatikom K et al. 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. 2004 Cancer Res. pmid:15604240
Panikashvili D et al. CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibition. 2005 J. Cereb. Blood Flow Metab. pmid:15729296
Gopez JJ et al. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. 2005 Neurosurgery pmid:15730585
Oka S et al. Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear. 2005 J. Biol. Chem. pmid:15749716
Kishimoto S et al. Endogenous cannabinoid receptor ligand induces the migration of human natural killer cells. 2005 J. Biochem. pmid:15749836
Julien B et al. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. 2005 Gastroenterology pmid:15765409
Kaplan BL et al. 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2. 2005 J. Leukoc. Biol. pmid:15774549
Kurabayashi M et al. 2-Arachidonoylglycerol increases in ischemia-reperfusion injury of the rat liver. 2005 Jan-Feb J Invest Surg pmid:15804949
Chen J et al. Finding of endocannabinoids in human eye tissues: implications for glaucoma. 2005 Biochem. Biophys. Res. Commun. pmid:15823551
Harada N et al. Effects of cannabinoids on colonic muscle contractility and tension in guinea pigs. 2005 J Nippon Med Sch pmid:15834207
Sipe JC et al. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. 2005 J. Leukoc. Biol. pmid:15845647
Zhao Q et al. 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. 2005 J. Biol. Chem. pmid:15886210
van der Stelt M et al. A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. 2005 FASEB J. pmid:15894565
Venderova K et al. Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus. 2005 Exp. Neurol. pmid:15899265
Kola B et al. Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. 2005 J. Biol. Chem. pmid:15899896
Shoemaker JL et al. The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors. 2005 J. Pharmacol. Exp. Ther. pmid:15901805
Rouzer CA and Marnett LJ Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus. 2005 J. Biol. Chem. pmid:15917246
Nithipatikom K et al. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. 2005 Biochem. Biophys. Res. Commun. pmid:15919052
Darmani NA et al. Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. 2005 Neuropharmacology pmid:15921709
Hohmann AG et al. An endocannabinoid mechanism for stress-induced analgesia. 2005 Nature pmid:15973410
Saario SM et al. Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. 2005 Chem. Biol. pmid:15975510
Ramos JA et al. Therapeutic potential of the endocannabinoid system in the brain. 2005 Mini Rev Med Chem pmid:16026307
Maejima T et al. Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. 2005 J. Neurosci. pmid:16033892
Jung KM et al. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. 2005 Mol. Pharmacol. pmid:16051747
Wahn H et al. The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:16055511
Lambert DM and Fowler CJ The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. 2005 J. Med. Chem. pmid:16078824
Shoemaker JL et al. Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors. 2005 J. Pharmacol. Exp. Ther. pmid:16081674
Avraham Y et al. Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. 2006 Neurobiol. Dis. pmid:16102970
Secko D Analgesia through endogenous cannabinoids. 2005 CMAJ pmid:16103504
Wagner JA et al. Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts. 2005 J. Cardiovasc. Pharmacol. pmid:16116341
Makara JK et al. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. 2005 Nat. Neurosci. pmid:16116451
McPartland JM et al. Cannabimimetic effects of osteopathic manipulative treatment. 2005 J Am Osteopath Assoc pmid:16118355
Sancho R et al. Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. 2005 J. Immunol. pmid:16148147
Hayase T et al. Persistent anxiogenic effects of a single or repeated doses of cocaine and methamphetamine: interactions with endogenous cannabinoid receptor ligands. 2005 Behav Pharmacol pmid:16148444
Gabbay E et al. Endocannabinoids and liver disease--review. 2005 Liver Int. pmid:16162147
Straiker A and Mackie K Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. 2005 J. Physiol. (Lond.) pmid:16179366
Vandevoorde S et al. Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. 2005 Biochem. Biophys. Res. Commun. pmid:16181610