2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Ganglion Cysts D045888 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


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What lipids are associated with 2-arachidonoylglycerol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Wang X et al. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. 2016 Biomed Res Int pmid:26904688
Wills KL et al. Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats. 2016 Neuropsychopharmacology pmid:26647976
Gobira PH et al. Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. 2016 Eur Neuropsychopharmacol pmid:26628106
Signorello MG and Leoncini G Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol. 2016 J. Cell. Biochem. pmid:26460717
Wang F et al. 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. 2016 Rejuvenation Res pmid:26414218
Morena M et al. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. 2016 Neuropharmacology pmid:27553121
Veeraraghavan P et al. A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. 2016 Neuroscience pmid:27450568
Yang W et al. Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. 2016 Neuroscience pmid:26621126
Sustkova-Fiserova M et al. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. 2016 Psychopharmacology (Berl.) pmid:26507196
Leishman E et al. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. 2016 Biochim. Biophys. Acta pmid:26956082
Petrosino S et al. The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels. 2016 Br. J. Pharmacol. pmid:25598150
Yan W et al. NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. 2016 Sci Rep pmid:26928013
Hartley ND et al. 2-arachidonoylglycerol signaling impairs short-term fear extinction. 2016 Transl Psychiatry pmid:26926885
Brindisi M et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. 2016 J. Med. Chem. pmid:26888301
Tegeder I Endocannabinoids as Guardians of Metastasis. 2016 Int J Mol Sci pmid:26875980
Pastor A et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. 2016 PLoS ONE pmid:26849214
Matthews AT et al. Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. 2016 Am. J. Physiol., Cell Physiol. pmid:27784678
Fisette A et al. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. 2016 Cell Rep pmid:27783937
Sugaya Y et al. Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. 2016 Cell Rep pmid:27452464
Bosch-Bouju C et al. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. 2016 Cell Rep pmid:27452462