2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Fetal Nutrition Disorders D048070 1 associated lipids
Ganglion Cysts D045888 1 associated lipids
Neuromyelitis Optica D009471 2 associated lipids
Acute Pain D059787 3 associated lipids
Head Injuries, Closed D016489 5 associated lipids
Brain Concussion D001924 5 associated lipids
Fragile X Syndrome D005600 5 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Morphine Dependence D009021 9 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
González-Mariscal I et al. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. 2016 Mol. Cell. Endocrinol. pmid:26724516
Lu HC and Mackie K An Introduction to the Endogenous Cannabinoid System. 2016 Biol. Psychiatry pmid:26698193
Wang F et al. 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. 2016 Rejuvenation Res pmid:26414218
Veeraraghavan P et al. A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. 2016 Neuroscience pmid:27450568
van Zadelhoff G and van der Stelt M Oxygenation of Anandamide by Lipoxygenases. 2016 Methods Mol. Biol. pmid:27245907
Rajaraman G et al. G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. 2016 Mol Nutr Food Res pmid:26337420
Tegeder I Endocannabinoids as Guardians of Metastasis. 2016 Int J Mol Sci pmid:26875980
Pastor A et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. 2016 PLoS ONE pmid:26849214
Wilkerson JL et al. The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. 2016 J. Pharmacol. Exp. Ther. pmid:26791602
Aso C et al. Protein purification and cloning of diacylglycerol lipase from rat brain. 2016 J. Biochem. pmid:26790472
Buczynski MW et al. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26755579
Volk DW and Lewis DA The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. 2016 Biol. Psychiatry pmid:26210060
Sugaya Y et al. Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. 2016 Cell Rep pmid:27452464
Bosch-Bouju C et al. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. 2016 Cell Rep pmid:27452462
Imperatore R et al. Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. 2016 Pharmacol. Res. pmid:27436148
Janssen FJ and van der Stelt M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. 2016 Bioorg. Med. Chem. Lett. pmid:27394666
Mwanza C et al. Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:27318292
Martins CJ et al. Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. 2015 PLoS ONE pmid:26561012
García del Caño G et al. Nuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity. 2015 J. Neurochem. pmid:25308538
Ma L et al. Involvement of cannabinoid receptors in infrasonic noise-induced neuronal impairment. 2015 Acta Biochim. Biophys. Sin. (Shanghai) pmid:26058582
Katz PS et al. Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. 2015 J. Neurotrauma pmid:25166905
Alizadeh A et al. Role of cannabinoidergic system on food intake in neonatal layer-type chicken. 2015 Vet. Res. Commun. pmid:25902906
Zhang Z et al. Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. 2015 Hippocampus pmid:25131612
Gomez O et al. A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. 2015 J Neuroimmune Pharmacol pmid:25900077
Shimizu T et al. Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat. 2015 Neuropharmacology pmid:25882827
Smith M et al. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. 2015 PLoS ONE pmid:26414859
Gong Y et al. Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC-MS/MS: Application in tumor-bearing mice. 2015 J Pharm Biomed Anal pmid:25863017
Altamura C et al. Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer's Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline. 2015 J. Alzheimers Dis. pmid:25818503
Lecru L et al. Cannabinoid receptor 1 is a major mediator of renal fibrosis. 2015 Kidney Int. pmid:25760323
Turcotte C et al. Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. 2015 J. Leukoc. Biol. pmid:25877930
Spaziano G et al. Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. 2015 Biomed Res Int pmid:25866824
Subbanna S et al. Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. 2015 J. Neurochem. pmid:25857698
Nicholson J et al. Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. 2015 PLoS ONE pmid:25835291
Patsenker E et al. Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. 2015 Int J Mol Sci pmid:25826533
Mecha M et al. Endocannabinoids drive the acquisition of an alternative phenotype in microglia. 2015 Brain Behav. Immun. pmid:26086345
Juan CC et al. Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome. 2015 Fertil. Steril. pmid:25935491
Vázquez C et al. Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. 2015 Neurobiol. Dis. pmid:25917763
Jokisch V et al. Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. 2015 Am J Perinatol pmid:25915139
Manduca A et al. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. 2015 Eur Neuropsychopharmacol pmid:25914159
Llorente-Berzal A et al. 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. 2015 Psychopharmacology (Berl.) pmid:25814137
Park SW et al. Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. 2015 Head Neck pmid:24797795
Checa A et al. Lipid mediator profile in vernix caseosa reflects skin barrier development. 2015 Sci Rep pmid:26521946
Jalin AM et al. Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. 2015 PLoS ONE pmid:26517721
Morena M et al. Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats. 2015 J. Neurosci. pmid:26468197
Zheng G et al. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. 2015 Exp. Neurol. pmid:26408049
La Porta C et al. Role of the endocannabinoid system in the emotional manifestations of osteoarthritis pain. 2015 Pain pmid:26067584
Hutch CR et al. An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. 2015 Neuroscience pmid:26037800
Dotsey EY et al. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. 2015 Chem. Biol. pmid:26000748
Chicca A et al. 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. 2015 J Neuroinflammation pmid:25962384
Liu Z et al. Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice. 2015 Sci Rep pmid:25830356