2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Inflammation D007249 119 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Colitis D003092 69 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

Download all related citations
Per page 10 20 50 100 | Total 1060
Authors Title Published Journal PubMed Link
Limebeer CL et al. Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. 2016 Behav. Neurosci. pmid:26974857
Zhang L et al. Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. 2016 Neuroscience pmid:26924019
Tomas-Roig J et al. Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. 2016 Behav. Brain Res. pmid:26815100
Siegmund SV et al. Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. 2016 Biochem. Biophys. Res. Commun. pmid:26801558
Yi B et al. Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors. 2016 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:26780604
Costa MA et al. The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast. 2016 Biochim. Biophys. Acta pmid:26698196
González-Mariscal I et al. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. 2016 Mol. Cell. Endocrinol. pmid:26724516
Wills KL et al. Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats. 2016 Neuropsychopharmacology pmid:26647976
Gobira PH et al. Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. 2016 Eur Neuropsychopharmacol pmid:26628106
Lu HC and Mackie K An Introduction to the Endogenous Cannabinoid System. 2016 Biol. Psychiatry pmid:26698193
Signorello MG and Leoncini G Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol. 2016 J. Cell. Biochem. pmid:26460717
Wang F et al. 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. 2016 Rejuvenation Res pmid:26414218
Sanchez AM et al. Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. 2016 Reprod Sci pmid:26887427
Morena M et al. Neurobiological Interactions Between Stress and the Endocannabinoid System. 2016 Neuropsychopharmacology pmid:26068727
Knani I et al. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. 2016 Mol Metab pmid:27900261
Liu X et al. Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. 2016 Sci Rep pmid:27775008
Jenniches I and Zimmer A Reply to: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. 2016 Biol. Psychiatry pmid:26410564
Patel S et al. The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. 2016 Biol. Psychiatry pmid:26212898
Kudalkar SN et al. Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. 2016 Methods Mol. Biol. pmid:27245906
Jung KM and Piomelli D Assay of Monoacylglycerol Lipase Activity. 2016 Methods Mol. Biol. pmid:27245902
Doenni VM et al. Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. 2016 Brain Behav. Immun. pmid:27453335
Dong L et al. Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. 2016 J. Lipid Res. pmid:27059979
Schlabritz-Loutsevitch N et al. Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. 2016 Med. Hypotheses pmid:27959272
Morena M et al. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. 2016 Neuropharmacology pmid:27553121
Veeraraghavan P et al. A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. 2016 Neuroscience pmid:27450568
van Zadelhoff G and van der Stelt M Oxygenation of Anandamide by Lipoxygenases. 2016 Methods Mol. Biol. pmid:27245907
Iannotti FA et al. Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. 2016 Prog. Lipid Res. pmid:26965148
Gamelin FX et al. Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. 2016 J. Physiol. Biochem. pmid:26880264
Monteleone AM et al. Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. 2016 Eur J Nutr pmid:26759262
Yang W et al. Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. 2016 Neuroscience pmid:26621126
Sustkova-Fiserova M et al. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. 2016 Psychopharmacology (Berl.) pmid:26507196
Rajaraman G et al. G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. 2016 Mol Nutr Food Res pmid:26337420
Malek N et al. The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. 2016 Pharmacol. Res. pmid:27326920
Di S et al. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. 2016 J. Neurosci. pmid:27511017
Aaltonen N et al. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). 2016 J. Pharmacol. Exp. Ther. pmid:27451409
Sharkey KA and Wiley JW The Role of the Endocannabinoid System in the Brain-Gut Axis. 2016 Gastroenterology pmid:27133395
Sido JM et al. Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed-type hypersensitivity. 2016 Eur. J. Immunol. pmid:27064137
Brose SA et al. Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. 2016 Lipids pmid:27021494
Delgado-Peraza F et al. Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. 2016 Mol. Pharmacol. pmid:27009233
Miller MR et al. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. 2016 Science pmid:26989199
Pastor A et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. 2016 PLoS ONE pmid:26849214
Wilkerson JL et al. The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. 2016 J. Pharmacol. Exp. Ther. pmid:26791602
Aso C et al. Protein purification and cloning of diacylglycerol lipase from rat brain. 2016 J. Biochem. pmid:26790472
Buczynski MW et al. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26755579
Ogasawara D et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26668358
Hanlon EC et al. Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. 2016 Sleep pmid:26612385
Vujic N et al. Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. 2016 Atherosclerosis pmid:26584135
Mann A et al. Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? 2016 J Basic Clin Physiol Pharmacol pmid:26565551
Grabner GF et al. Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. 2016 J. Biol. Chem. pmid:26565024
Matthews AT et al. Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. 2016 Am. J. Physiol., Cell Physiol. pmid:27784678
Sticht MA et al. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. 2016 Neuropharmacology pmid:26541329
McReynolds JR et al. CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. 2016 Psychopharmacology (Berl.) pmid:26455361
Lim J et al. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. 2016 Neuropsychopharmacology pmid:26361059
Stark DT and Caprioli J Subcellular Localization of a 2-Arachidonoyl Glycerol Signaling Cassette in Retinal Ganglion Cell Axonal Growth In Vitro. 2016 Invest. Ophthalmol. Vis. Sci. pmid:28002563
Wang X et al. Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat. 2016 Epilepsy Res. pmid:27810514
Volk DW and Lewis DA The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia. 2016 Biol. Psychiatry pmid:26210060
Araki M et al. Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. 2016 J. Biochem. pmid:27198176
Fisette A et al. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. 2016 Cell Rep pmid:27783937
Sugaya Y et al. Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. 2016 Cell Rep pmid:27452464
Bosch-Bouju C et al. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. 2016 Cell Rep pmid:27452462
Cristino L et al. Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency. 2016 Neuropsychopharmacology pmid:26081302
Imperatore R et al. Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. 2016 Pharmacol. Res. pmid:27436148
Wiley JL et al. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. 2016 Behav Pharmacol pmid:27385208
Janssen FJ and van der Stelt M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. 2016 Bioorg. Med. Chem. Lett. pmid:27394666
Mwanza C et al. Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:27318292
Bisogno T Assay of DAGLα/β Activity. 2016 Methods Mol. Biol. pmid:27245901
Battista N and Sergi M Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. 2016 Methods Mol. Biol. pmid:27245888
Brosnihan KB et al. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. 2015 Reprod. Biol. Endocrinol. pmid:25596750
Griebel G et al. Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. 2015 Sci Rep pmid:25560837
Zhang J et al. Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. 2015 J. Cereb. Blood Flow Metab. pmid:25492114
Shonesy BC et al. The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. 2015 Neuropharmacology pmid:25484252
Hanlon EC et al. Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. 2015 J. Clin. Endocrinol. Metab. pmid:25368979
Alizadeh A et al. Role of cannabinoidergic system on food intake in neonatal layer-type chicken. 2015 Vet. Res. Commun. pmid:25902906
Gomez O et al. A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways. 2015 J Neuroimmune Pharmacol pmid:25900077
Shimizu T et al. Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat. 2015 Neuropharmacology pmid:25882827
Gong Y et al. Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC-MS/MS: Application in tumor-bearing mice. 2015 J Pharm Biomed Anal pmid:25863017
Altamura C et al. Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer's Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline. 2015 J. Alzheimers Dis. pmid:25818503
Lecru L et al. Cannabinoid receptor 1 is a major mediator of renal fibrosis. 2015 Kidney Int. pmid:25760323
Mann A et al. Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. 2015 J Neuroimmune Pharmacol pmid:25721934
Mennella I et al. Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans. 2015 J. Nutr. pmid:26180248
Szekeres M et al. Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. 2015 Mol. Cell. Endocrinol. pmid:25595485
Scotchie JG et al. Endocannabinoid regulation in human endometrium across the menstrual cycle. 2015 Reprod Sci pmid:24819878
Jokisch V et al. Endocannabinoid Levels in Newborns in Relation to the Mode of Delivery. 2015 Am J Perinatol pmid:25915139
Manduca A et al. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. 2015 Eur Neuropsychopharmacol pmid:25914159
Llorente-Berzal A et al. 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. 2015 Psychopharmacology (Berl.) pmid:25814137
Pisanti S et al. Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. 2015 J. Cell. Physiol. pmid:25684344
Aliczki M et al. Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. 2015 Psychopharmacology (Berl.) pmid:25547462
Liu J et al. Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. 2015 Neurotoxicology pmid:26215119
Orellana-Serradell O et al. Proapoptotic effect of endocannabinoids in prostate cancer cells. 2015 Oncol. Rep. pmid:25606819
Alhouayek M et al. N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. 2015 FASEB J. pmid:25384424
Park SW et al. Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species. 2015 Head Neck pmid:24797795
Mounsey RB et al. Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. 2015 Exp. Neurol. pmid:26244281
Guggenhuber S et al. Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility. 2015 Int. J. Neuropsychopharmacol. pmid:26232789
Imperatore R et al. Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior. 2015 J. Neurochem. pmid:26223500
Anderson GR et al. β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. 2015 Cell pmid:26213384
Viader A et al. Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. 2015 Cell Rep pmid:26212325
Straiker A et al. Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. 2015 Pharmacol. Res. pmid:26211948
Kita Y et al. Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. 2015 PLoS ONE pmid:26196692
Lee SH et al. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. 2015 J. Neurosci. pmid:26157003
Parker KE et al. Effects of co-administration of 2-arachidonylglycerol (2-AG) and a selective µ-opioid receptor agonist into the nucleus accumbens on high-fat feeding behaviors in the rat. 2015 Brain Res. pmid:26100333