2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Inflammation D007249 119 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Colitis D003092 69 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

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What functions are associated with 2-arachidonoylglycerol?


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What lipids are associated with 2-arachidonoylglycerol?

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What genes are associated with 2-arachidonoylglycerol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Sancho R et al. Mechanisms of HIV-1 inhibition by the lipid mediator N-arachidonoyldopamine. 2005 J. Immunol. pmid:16148147
Lu TS et al. Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. 2008 J. Immunol. pmid:18941231
Chouinard F et al. The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. 2011 J. Immunol. pmid:21278347
Marazzi J et al. Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. 2011 J. Immunol. Methods pmid:21920367
Czifra G et al. Endocannabinoids regulate growth and survival of human eccrine sweat gland-derived epithelial cells. 2012 J. Invest. Dermatol. pmid:22513781
Turcotte C et al. Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites. 2015 J. Leukoc. Biol. pmid:25877930
Oka S et al. 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. 2004 J. Leukoc. Biol. pmid:15316028
Chouinard F et al. 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. 2013 J. Leukoc. Biol. pmid:23242611
Kaplan BL et al. 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2. 2005 J. Leukoc. Biol. pmid:15774549
Sipe JC et al. Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. 2005 J. Leukoc. Biol. pmid:15845647
Nithipatikom K et al. A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. 2014 J. Lipid Res. pmid:24958911
Pastor A et al. Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. 2014 J. Lipid Res. pmid:24610889
Fanelli F et al. Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS. 2012 J. Lipid Res. pmid:22172516
Dong L et al. Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. 2016 J. Lipid Res. pmid:27059979
Kantae V et al. Quantitative profiling of endocannabinoids and related -acylethanolamines in human CSF using nano LC-MS/MS. 2017 J. Lipid Res. pmid:27999147
Wollank Y et al. Inhibition of FAAH confers increased stem cell migration via PPARα. 2015 J. Lipid Res. pmid:26263913
Navia-Paldanius D et al. Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). 2012 J. Lipid Res. pmid:22969151
Skonberg C et al. Pitfalls in the sample preparation and analysis of N-acylethanolamines. 2010 J. Lipid Res. pmid:20447930
Lambert DM and Fowler CJ The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. 2005 J. Med. Chem. pmid:16078824
Cisneros JA et al. Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. 2007 J. Med. Chem. pmid:17764163
Barnett-Norris J et al. Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories. 1998 J. Med. Chem. pmid:9822555
Martín-Couce L et al. Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. 2011 J. Med. Chem. pmid:21675776
van der Stelt M et al. Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase. 2002 J. Med. Chem. pmid:12166944
Ortar G et al. Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. 2008 J. Med. Chem. pmid:18831576
Brizzi A et al. Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. 2011 J. Med. Chem. pmid:22044209
Brindisi M et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. 2016 J. Med. Chem. pmid:26888301
Tiburu EK and Shen L Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. 2014 J. Membr. Biol. pmid:24402242
Amorós I et al. Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. 2010 J. Mol. Cell. Cardiol. pmid:19616555
Weis F et al. Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. 2010 J. Mol. Cell. Cardiol. pmid:19931541
D'Argenio G et al. Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. 2007 J. Mol. Med. pmid:17396241
Catani MV et al. Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. 2009 J. Mol. Med. pmid:18820887
Zou Z et al. Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. 2016 J. Mol. Neurosci. pmid:27129498
Zou Z et al. Effect of Homocysteine on Voltage-Gated Sodium Channel Currents in Primary Cultured Rat Caudate Nucleus Neurons and Its Modulation by 2-Arachidonylglycerol. 2015 J. Mol. Neurosci. pmid:26179279
Dong M et al. Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through CB1 receptor. 2015 J. Mol. Neurosci. pmid:25007951
Lu Y et al. Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. 2014 J. Mol. Neurosci. pmid:24510751
Witting A et al. Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice. 2004 J. Neurochem. pmid:15189359
Belluomo I et al. Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. 2015 J. Neurochem. pmid:25626460
García del Caño G et al. Nuclear diacylglycerol lipase-α in rat brain cortical neurons: evidence of 2-arachidonoylglycerol production in concert with phospholipase C-β activity. 2015 J. Neurochem. pmid:25308538
Oka S et al. Ether-linked analogue of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species. 2003 J. Neurochem. pmid:12787057
Subbanna S et al. Postnatal ethanol exposure alters levels of 2-arachidonylglycerol-metabolizing enzymes and pharmacological inhibition of monoacylglycerol lipase does not cause neurodegeneration in neonatal mice. 2015 J. Neurochem. pmid:25857698
Wu X et al. Alteration of endocannabinoid system in human gliomas. 2012 J. Neurochem. pmid:22176552
Rhee MH et al. Functional role of tryptophan residues in the fourth transmembrane domain of the CB(2) cannabinoid receptor. 2000 J. Neurochem. pmid:11080201
Palomäki VA et al. Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography. 2007 J. Neurochem. pmid:17254014
Sang N et al. COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. 2007 J. Neurochem. pmid:17539917
Maccarrone M et al. Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism. 2003 J. Neurochem. pmid:12716433
Degn M et al. Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice. 2007 J. Neurochem. pmid:17868306
Sarmad S et al. Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. 2011 J. Neurochem. pmid:21375532
Jarrahian A et al. Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. 2000 J. Neurochem. pmid:10820223
Hansen HH et al. Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. 2001 J. Neurochem. pmid:11579150
Maccarrone M et al. Anandamide degradation and N-acylethanolamines level in wild-type and CB1 cannabinoid receptor knockout mice of different ages. 2001 J. Neurochem. pmid:11461969
Alvarez-Jaimes L et al. Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. 2009 J. Neurochem. pmid:19650871
Maccarrone M et al. Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum. 2009 J. Neurochem. pmid:19187444
Di Marzo V et al. Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain. 2000 J. Neurochem. pmid:11080195
Bisogno T et al. Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin. 1999 J. Neurochem. pmid:10217292
Placzek EA et al. Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. 2008 J. Neurochem. pmid:18778304
Maccarrone M et al. Gas chromatography-mass spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and human cells in culture. 2001 J. Neurochem. pmid:11208922
Baur R et al. Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors. 2013 J. Neurochem. pmid:23600744
Parrish JC and Nichols DE Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. 2006 J. Neurochem. pmid:17010161
Imperatore R et al. Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior. 2015 J. Neurochem. pmid:26223500
Bisogno T Endogenous cannabinoids: structure and metabolism. 2008 J. Neuroendocrinol. pmid:18426492
Di Filippo M et al. Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. 2008 J. Neurol. Neurosurg. Psychiatr. pmid:18535023
Yuan S and Burrell BD Nonnociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism. 2013 J. Neurophysiol. pmid:24027102
Sheinin A et al. Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. 2008 J. Neurophysiol. pmid:18497350
Gao Y et al. Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. 2010 J. Neurosci. pmid:20147530
DiPatrizio NV and Simansky KJ Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. 2008 J. Neurosci. pmid:18815256
Zhang J et al. Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. 2014 J. Neurosci. pmid:25378159
Sepers MD et al. Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model. 2018 J. Neurosci. pmid:29192125
Walter L et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. 2003 J. Neurosci. pmid:12598628
Gregg LC et al. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. 2012 J. Neurosci. pmid:22787031
Sugaya Y et al. The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. 2013 J. Neurosci. pmid:23426686
Derkinderen P et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. 2003 J. Neurosci. pmid:12657697
Muccioli GG et al. Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. 2007 J. Neurosci. pmid:17360910
Yuan S and Burrell BD Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation. 2013 J. Neurosci. pmid:23467351
Uchigashima M et al. Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. 2007 J. Neurosci. pmid:17409230
Walter L et al. ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. 2004 J. Neurosci. pmid:15371507
Massa F et al. Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. 2010 J. Neurosci. pmid:20445053
Perez-Rosello T et al. Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. 2013 J. Neurosci. pmid:23719795
Oudin MJ et al. Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. 2011 J. Neurosci. pmid:21411643
Hashimotodani Y et al. Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. 2011 J. Neurosci. pmid:21414931
van der Stelt M et al. Exogenous anandamide protects rat brain against acute neuronal injury in vivo. 2001 J. Neurosci. pmid:11698588
Du H et al. Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG. 2013 J. Neurosci. pmid:24048832
Melis M et al. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. 2004 J. Neurosci. pmid:15564588
Keimpema E et al. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. 2010 J. Neurosci. pmid:20962221
Lerner TN et al. Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. 2010 J. Neurosci. pmid:20147543
Song J et al. Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network. 2012 J. Neurosci. pmid:22496555
Subbanna S et al. Anandamide-CB1 receptor signaling contributes to postnatal ethanol-induced neonatal neurodegeneration, adult synaptic, and memory deficits. 2013 J. Neurosci. pmid:23575834
Uchigashima M et al. Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. 2011 J. Neurosci. pmid:21613483
Melis M et al. Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. 2014 J. Neurosci. pmid:25232109
Maejima T et al. Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. 2005 J. Neurosci. pmid:16033892
Ade KK and Lovinger DM Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum. 2007 J. Neurosci. pmid:17329438
Marinelli S et al. The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. 2008 J. Neurosci. pmid:19074027
Malcher-Lopes R et al. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. 2006 J. Neurosci. pmid:16775153
Yoshida T et al. Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. 2006 J. Neurosci. pmid:16672646
Katona I et al. Molecular composition of the endocannabinoid system at glutamatergic synapses. 2006 J. Neurosci. pmid:16723519
Won YJ et al. Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. 2009 J. Neurosci. pmid:19864572
Feliú A et al. 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination. 2017 J. Neurosci. pmid:28751457
Qin N et al. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. 2008 J. Neurosci. pmid:18550765
Gubellini P et al. Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission. 2002 J. Neurosci. pmid:12177188
Lee SH et al. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. 2015 J. Neurosci. pmid:26157003
Breunig E et al. The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. 2010 J. Neurosci. pmid:20592217