2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Inflammation D007249 119 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Colitis D003092 69 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Baldassarri S et al. The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. 2008 J. Thromb. Haemost. pmid:18647220
Ortar G et al. Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. 2008 Eur J Med Chem pmid:17452063
Hill MN et al. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. 2008 Hippocampus pmid:18058925
Maccarrone M et al. Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. 2008 Nat. Neurosci. pmid:18204441
Starowicz KM et al. Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. 2008 Obesity (Silver Spring) pmid:18239598
Shimizu T and Yokotani K Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. 2008 Eur. J. Pharmacol. pmid:18234185
Moreira FA et al. Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. 2008 Neuropharmacology pmid:17709120
Tam J et al. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. 2008 FASEB J. pmid:17704191
Chiu CQ and Castillo PE Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. 2008 Neuropharmacology pmid:17706254
Vellani V et al. Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin. 2008 Neuropharmacology pmid:18329052
Engeli S et al. Peripheral endocannabinoid system activity in patients treated with sibutramine. 2008 Obesity (Silver Spring) pmid:18356837
Guindon J and Hohmann AG A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. 2008 Br. J. Pharmacol. pmid:18297102
Oláh M et al. The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. 2008 Mol. Cell. Endocrinol. pmid:18308464
Hu SS et al. Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. 2008 Br. J. Pharmacol. pmid:18297109
Friedman SL and Nieto N Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. 2008 Cell Metab. pmid:18316020
Hill MN et al. Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. 2008 Pharmacopsychiatry pmid:18311684
Jeong WI et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. 2008 Cell Metab. pmid:18316028
Palkovits M et al. Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. 2008 Neuroscience pmid:18343585
Rubio M et al. CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. 2008 Neuropharmacology pmid:18371990
Marinelli S et al. The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. 2008 J. Neurosci. pmid:19074027
Lu TS et al. Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. 2008 J. Immunol. pmid:18941231
Sheinin A et al. Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. 2008 J. Neurophysiol. pmid:18497350
Zhang J and Chen C Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. 2008 J. Biol. Chem. pmid:18534982
Nabemoto M et al. Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. 2008 Eur. J. Pharmacol. pmid:18539271
Endsley MP et al. Expression and function of fatty acid amide hydrolase in prostate cancer. 2008 Int. J. Cancer pmid:18566995
Muccioli GG and Stella N An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. 2008 Anal. Biochem. pmid:17981259
Thiemann G et al. The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. 2008 Behav. Brain Res. pmid:17988751
Sakamoto Y et al. Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock. 2007 Sep-Oct ASAIO J. pmid:17885340
Fan SF and Yazulla S Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol. 2007 May-Jun Vis. Neurosci. pmid:17592669
Oka S et al. Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes. 2007 J. Biochem. pmid:17339228
D'Argenio G et al. Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. 2007 J. Mol. Med. pmid:17396241
Marrs W and Stella N 2-AG + 2 new players = forecast for therapeutic advances. 2007 Chem. Biol. pmid:18096497
Rubio M et al. Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. 2007 Neurosci. Lett. pmid:17574742
Ryberg E et al. The orphan receptor GPR55 is a novel cannabinoid receptor. 2007 Br. J. Pharmacol. pmid:17876302
Karsak M et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. 2007 Science pmid:17556587
Endsley MP et al. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. 2007 Int. J. Cancer pmid:17443494
Richardson D et al. Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry. 2007 Anal. Biochem. pmid:17141174
Williams J et al. Quantitative method for the profiling of the endocannabinoid metabolome by LC-atmospheric pressure chemical ionization-MS. 2007 Anal. Chem. pmid:17600384
Coopman K et al. Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. 2007 Int. Immunopharmacol. pmid:17276894
Ryan D et al. Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. 2007 Eur. J. Neurosci. pmid:17419758
Gonthier MP et al. Identification of endocannabinoids and related compounds in human fat cells. 2007 Obesity (Silver Spring) pmid:17426318
Basavarajappa BS Critical enzymes involved in endocannabinoid metabolism. 2007 Protein Pept. Lett. pmid:17346227
Centonze D et al. The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis. 2007 Brain pmid:17626034
Hillard CJ et al. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. 2007 Br. J. Pharmacol. pmid:17891162
Tanikawa T et al. Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice. 2007 Microbiol. Immunol. pmid:17951991
Hohmann AG Inhibitors of monoacylglycerol lipase as novel analgesics. 2007 Br. J. Pharmacol. pmid:17293886
Palomäki VA et al. Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography. 2007 J. Neurochem. pmid:17254014
Muccioli GG et al. Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. 2007 J. Neurosci. pmid:17360910
Bátkai S et al. Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. 2007 FASEB J. pmid:17327359
Labar G et al. Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. 2007 Chembiochem pmid:17579916
Wang H et al. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. 2007 Prostaglandins Other Lipid Mediat. pmid:17259073
Adermark L and Lovinger DM Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18077376
Sang N et al. COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. 2007 J. Neurochem. pmid:17539917
Jung KM et al. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. 2007 Mol. Pharmacol. pmid:17584991
Béquet F et al. CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. 2007 Eur. J. Neurosci. pmid:18052990
Siegmund SV et al. The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. 2007 FASEB J. pmid:17440119
Uchigashima M et al. Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. 2007 J. Neurosci. pmid:17409230
Lafourcade M et al. Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. 2007 PLoS ONE pmid:17684555
Gokoh M et al. 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. 2007 Biol. Pharm. Bull. pmid:17603153
Sarchielli P et al. Endocannabinoids in chronic migraine: CSF findings suggest a system failure. 2007 Neuropsychopharmacology pmid:17119542
Cisneros JA et al. Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. 2007 J. Med. Chem. pmid:17764163
Degn M et al. Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice. 2007 J. Neurochem. pmid:17868306
Sugiura T [2-Arachidonoylglycerol: an endogenous cannabinoid receptor ligand]. 2007 Seikagaku pmid:17763698
Smid SD et al. The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. 2007 Eur. J. Pharmacol. pmid:17706636
He F et al. Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. 2007 Mol. Pharmacol. pmid:17698952
Rossi G et al. Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. 2007 Endocrinology pmid:17110429
Saario SM and Laitinen JT Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol. 2007 Chem. Biodivers. pmid:17712832
Ho WS and Randall MD Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. 2007 Br. J. Pharmacol. pmid:17245358
Vadivel SK et al. Conformationally constrained analogues of 2-arachidonoylglycerol. 2007 Bioorg. Med. Chem. Lett. pmid:17826996
Deshpande LS et al. Endocannabinoids block status epilepticus in cultured hippocampal neurons. 2007 Eur. J. Pharmacol. pmid:17174949
Côté M et al. Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men. 2007 Int J Obes (Lond) pmid:17224929
DeMorrow S et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. 2007 J. Biol. Chem. pmid:17329257
Ade KK and Lovinger DM Anandamide regulates postnatal development of long-term synaptic plasticity in the rat dorsolateral striatum. 2007 J. Neurosci. pmid:17329438
Kreutz S et al. Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures. 2007 Exp. Neurol. pmid:17010339
Suhara Y et al. Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. 2007 Bioorg. Med. Chem. pmid:17110113
Yu Y et al. Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. 2007 J. Biol. Chem. pmid:17110378
Straiker A and Mackie K Metabotropic suppression of excitation in murine autaptic hippocampal neurons. 2007 J. Physiol. (Lond.) pmid:17110416
Blankman JL et al. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. 2007 Chem. Biol. pmid:18096503
Guindon J et al. The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. 2007 Br. J. Pharmacol. pmid:17179944
Scutt A and Williamson EM Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. 2007 Calcif. Tissue Int. pmid:17205329
Imming P Fatty pain cures. 2007 Chem. Biol. pmid:18096498
King AR et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. 2007 Chem. Biol. pmid:18096504
Opitz CA et al. Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells. 2007 FEBS Lett. pmid:17904123
Mukhopadhyay S and Tulis DA Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. 2007 Cardiovasc Hematol Agents Med Chem pmid:17979695
Soria-Gómez E et al. Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. 2007 Br. J. Pharmacol. pmid:17549045
Dainese E et al. Modulation of the endocannabinoid system by lipid rafts. 2007 Curr. Med. Chem. pmid:17979719
Matias I et al. Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:17011761
Bari M et al. Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. 2006 J. Immunol. pmid:17015679
Spoto B et al. Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. 2006 Biochimie pmid:16949718
Wagner JA et al. 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. 2006 J. Cardiovasc. Pharmacol. pmid:16775503
Quistad GB et al. Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. 2006 Toxicol. Appl. Pharmacol. pmid:16310817
van der Stelt M et al. Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. 2006 Cell. Mol. Life Sci. pmid:16732431
Panikashvili D et al. The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. 2006 Neurobiol. Dis. pmid:16364651
Saario SM et al. URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. 2006 Chem. Biol. pmid:16931330
Sang N et al. PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. 2006 J. Physiol. (Lond.) pmid:16484297
Parkkari T et al. Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability. 2006 Bioorg. Med. Chem. Lett. pmid:16466915
Kurihara R et al. Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. 2006 J. Biol. Chem. pmid:16513651
Mestre L et al. The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection. 2006 Biochem. Pharmacol. pmid:16914119
Blüher M et al. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. 2006 Diabetes pmid:17065342
Oka S et al. Involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in oxazolone-induced contact dermatitis in mice. 2006 J. Immunol. pmid:17142782