| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Pain | D059787 | 3 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Fetal Nutrition Disorders | D048070 | 1 associated lipids |
| Ganglion Cysts | D045888 | 1 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
| Neurodegenerative Diseases | D019636 | 32 associated lipids |
| Cholangiocarcinoma | D018281 | 7 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frazier CJ | Key questions of endocannabinoid signalling in the CNS: which, where and when? | 2011 | J. Physiol. (Lond.) | pmid:22001725 |
| Nomura DK et al. | Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. | 2011 | Science | pmid:22021672 |
| Muppidi JR et al. | Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. | 2011 | J. Exp. Med. | pmid:21875957 |
| Marazzi J et al. | Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. | 2011 | J. Immunol. Methods | pmid:21920367 |
| Du H et al. | Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ. | 2011 | Br. J. Pharmacol. | pmid:21501147 |
| Raman P et al. | 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. | 2011 | Mol. Pharmacol. | pmid:21511917 |
| Bari M et al. | Characterization of the endocannabinoid system in mouse embryonic stem cells. | 2011 | Stem Cells Dev. | pmid:20446814 |
| Hofmann ME et al. | Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. | 2011 | J. Physiol. (Lond.) | pmid:21646412 |
| MartÃn-Couce L et al. | Development of endocannabinoid-based chemical probes for the study of cannabinoid receptors. | 2011 | J. Med. Chem. | pmid:21675776 |
| Busquets-Garcia A et al. | Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. | 2011 | Biol. Psychiatry | pmid:21684528 |
| Signorello MG et al. | Activation of human platelets by 2-arachidonoylglycerol: role of PKC in NO/cGMP pathway modulation. | 2011 | Curr Neurovasc Res | pmid:21675954 |
| Sarmad S et al. | Depolarizing and calcium-mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices. | 2011 | J. Neurochem. | pmid:21375532 |
| Marrs WR et al. | Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. | 2011 | J. Biol. Chem. | pmid:21665953 |
| Gantayet A et al. | Endocannabinoids and diacylglycerol kinase activity. | 2011 | Biochim. Biophys. Acta | pmid:21194521 |
| Duclos RI et al. | A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). | 2011 | J. Org. Chem. | pmid:21370840 |
| Shimizu T et al. | Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in bombesin-induced activation of central adrenomedullary outflow in rats. | 2011 | Eur. J. Pharmacol. | pmid:21371452 |
| Lourbopoulos A et al. | Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. | 2011 | Brain Res. | pmid:21406188 |
| Kortleven C et al. | The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. | 2011 | Eur. J. Neurosci. | pmid:21410793 |
| Oudin MJ et al. | Endocannabinoids regulate the migration of subventricular zone-derived neuroblasts in the postnatal brain. | 2011 | J. Neurosci. | pmid:21411643 |
| Hashimotodani Y et al. | Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol. | 2011 | J. Neurosci. | pmid:21414931 |
| Howlett AC et al. | Endocannabinoid tone versus constitutive activity of cannabinoid receptors. | 2011 | Br. J. Pharmacol. | pmid:21545414 |
| Taschler U et al. | Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. | 2011 | J. Biol. Chem. | pmid:21454566 |
| Mulder J et al. | Molecular reorganization of endocannabinoid signalling in Alzheimer's disease. | 2011 | Brain | pmid:21459826 |
| Carr RL et al. | Effect of developmental chlorpyrifos exposure, on endocannabinoid metabolizing enzymes, in the brain of juvenile rats. | 2011 | Toxicol. Sci. | pmid:21507991 |
| Chiba T et al. | A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011 | J. Pharm. Pharmacol. | pmid:21492165 |
| Vecchio AJ and Malkowski MG | The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. | 2011 | J. Biol. Chem. | pmid:21489986 |
| Balenga NA et al. | GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. | 2011 | Cell Res. | pmid:21467997 |
| Chen X et al. | Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults. | 2011 | Neuroscience | pmid:21256197 |
| De Petrocellis L et al. | Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. | 2011 | Br. J. Pharmacol. | pmid:21175579 |
| Jumpertz R et al. | Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21177788 |
| Di Marzo V | Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. | 2011 | Nat. Neurosci. | pmid:21187849 |
| Guindon J et al. | Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. | 2011 | Br. J. Pharmacol. | pmid:21198549 |
| Shekhar C | Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges. | 2011 | Chem. Biol. | pmid:21609833 |
| Quercioli A et al. | Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. | 2011 | Eur. Heart J. | pmid:21303779 |
| Cippitelli A et al. | Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. | 2011 | PLoS ONE | pmid:22140525 |
| Brizzi A et al. | Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. | 2011 | J. Med. Chem. | pmid:22044209 |
| Yoshino H et al. | Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. | 2011 | J. Physiol. (Lond.) | pmid:21807615 |
| Chouinard F et al. | The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. | 2011 | J. Immunol. | pmid:21278347 |
| Khasabova IA et al. | Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain. | 2011 | Pharmacol. Res. | pmid:21440630 |
| Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |
| Urbanski MJ et al. | Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. | 2010 | Neuroscience | pmid:20553815 |
| Smith SL and Rasmussen EB | Effects of 2-AG on the reinforcing properties of wheel activity in obese and lean Zucker rats. | 2010 | Behav Pharmacol | pmid:20512031 |
| Best AR and Regehr WG | Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. | 2010 | Neuron | pmid:20159441 |
| Yasuo S et al. | An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. | 2010 | Cell Tissue Res. | pmid:20165884 |
| Casida JE et al. | S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. | 2010 | Bioorg. Med. Chem. | pmid:20138526 |
| Guida M et al. | The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. | 2010 | Endocrinology | pmid:20133454 |
| Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
| Cobellis G et al. | A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. | 2010 | Biol. Reprod. | pmid:19812302 |
| Yasuo S et al. | Localization of an endocannabinoid system in the hypophysial pars tuberalis and pars distalis of man. | 2010 | Cell Tissue Res. | pmid:20957495 |
| Greco R et al. | Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. | 2010 | Cephalalgia | pmid:19515121 |
| Arevalo-Martin A et al. | The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. | 2010 | Neurobiol. Dis. | pmid:20156559 |
| Eisenstein SA et al. | A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. | 2010 | Pharmacol. Res. | pmid:20044005 |
| Amorós I et al. | Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. | 2010 | J. Mol. Cell. Cardiol. | pmid:19616555 |
| Frampton G et al. | Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. | 2010 | Exp. Cell Res. | pmid:20347808 |
| Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
| Hoot MR et al. | Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | 2010 | Brain Res. | pmid:20380816 |
| Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
| Caraceni P et al. | Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. | 2010 | Liver Int. | pmid:19840245 |
| Jiang S et al. | Endocannabinoids are expressed in bone marrow stromal niches and play a role in interactions of hematopoietic stem and progenitor cells with the bone marrow microenvironment. | 2010 | J. Biol. Chem. | pmid:20826813 |
| Piccinetti CC et al. | Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. | 2010 | Gen. Comp. Endocrinol. | pmid:19800340 |
| Xie S et al. | Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2. | 2010 | Chem. Res. Toxicol. | pmid:21049984 |
| Banni S and Di Marzo V | Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. | 2010 | Mol Nutr Food Res | pmid:20013888 |
| Fonseca BM et al. | The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: a role in uterine remodelling. | 2010 | Int. J. Biochem. Cell Biol. | pmid:20727980 |
| Romigi A et al. | Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. | 2010 | Epilepsia | pmid:19817812 |
| Ying-Ying Y and Lin HC | Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. | 2010 | Liver Int. | pmid:20408944 |
| Placzek EA et al. | Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). | 2010 | J Pharm Biomed Anal | pmid:20417049 |
| Massa F et al. | Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. | 2010 | J. Neurosci. | pmid:20445053 |
| Bardell TK and Barker EL | Activation of TRPC6 channels promotes endocannabinoid biosynthesis in neuronal CAD cells. | 2010 | Neurochem. Int. | pmid:20466028 |
| Naccarato M et al. | Possible Anandamide and Palmitoylethanolamide involvement in human stroke. | 2010 | Lipids Health Dis | pmid:20470384 |
| Muccioli GG | Endocannabinoid biosynthesis and inactivation, from simple to complex. | 2010 | Drug Discov. Today | pmid:20304091 |
| Kozono S et al. | Involvement of the endocannabinoid system in periodontal healing. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20233580 |
| Mukhopadhyay P et al. | CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. | 2010 | Br. J. Pharmacol. | pmid:20590569 |
| Keimpema E et al. | Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. | 2010 | J. Neurosci. | pmid:20962221 |
| Jumpertz R et al. | Circulating endocannabinoids and N-acyl-ethanolamides in patients with sleep apnea--specific role of oleoylethanolamide. | 2010 | Exp. Clin. Endocrinol. Diabetes | pmid:20429051 |
| Lerner TN et al. | Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 | J. Neurosci. | pmid:20147543 |
| Reggio PH | Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | 2010 | Curr. Med. Chem. | pmid:20166921 |
| Higuchi S et al. | Reducing acyl migration during purification of 2-arachidonoylglycerol from biological samples before gas chromatography mass spectrometry analysis. | 2010 | Anal Sci | pmid:21079352 |
| Evagorou A et al. | Hydrolysis of 2-arachidonoylglycerol in Tetrahymena thermophila. Identification and partial characterization of a Monoacylglycerol Lipase-like enzyme. | 2010 | Eur. J. Protistol. | pmid:20889319 |
| Weis F et al. | Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. | 2010 | J. Mol. Cell. Cardiol. | pmid:19931541 |
| Sang N et al. | Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. | 2010 | Neurochem. Int. | pmid:20064571 |
| Ishii Y et al. | F2-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia/reperfusion injury. | 2010 | J. Surg. Res. | pmid:19439322 |
| Minkkilä A et al. | Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. | 2010 | Curr Top Med Chem | pmid:20370710 |
| Kvasnicka T | [The endocannabinoid system and interference with thrombogenesis]. | 2010 | Vnitr Lek | pmid:20329583 |
| Maccarrone M et al. | Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. | 2010 | Neuropsychopharmacology | pmid:20393458 |
| Hurst DP et al. | A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. | 2010 | J. Biol. Chem. | pmid:20220143 |
| Telleria-Diaz A et al. | Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. | 2010 | Pain | pmid:19879047 |
| Bradshaw H | CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. | 2010 | Pain | pmid:19913999 |
| Zhang MY et al. | Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. | 2010 | J Mass Spectrom | pmid:19950120 |
| Labar G et al. | Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. | 2010 | Chembiochem | pmid:19957260 |
| Jyotaki M et al. | Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors. | 2010 | Endocr. J. | pmid:20431269 |
| Mukhopadhyay B et al. | Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. | 2010 | J. Biol. Chem. | pmid:20410309 |
| Maccarrone M | Endocannabinoid-binding receptors: old friends and new comers. | 2010 | Curr. Med. Chem. | pmid:20441559 |
| Skonberg C et al. | Pitfalls in the sample preparation and analysis of N-acylethanolamines. | 2010 | J. Lipid Res. | pmid:20447930 |
| Fino E et al. | Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. | 2010 | J. Physiol. (Lond.) | pmid:20603333 |
| Keown OP et al. | 2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors. | 2010 | Br J Clin Pharmacol | pmid:20653671 |
| Ho WS et al. | Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. | 2010 | Br. J. Pharmacol. | pmid:20590576 |
| Breunig E et al. | The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. | 2010 | J. Neurosci. | pmid:20592217 |
| Marrs WR et al. | The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. | 2010 | Nat. Neurosci. | pmid:20657592 |
| Shimizu T et al. | Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats. | 2010 | Eur. J. Pharmacol. | pmid:20519139 |
| Haj-Dahmane S and Shen RY | Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons. | 2010 | J. Physiol. (Lond.) | pmid:20498231 |