| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Placzek EA et al. | Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide). | 2010 | J Pharm Biomed Anal | pmid:20417049 |
| Spradley JM et al. | Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. | 2010 | Pharmacol. Res. | pmid:20416378 |
| Mukhopadhyay B et al. | Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma. | 2010 | J. Biol. Chem. | pmid:20410309 |
| Ying-Ying Y and Lin HC | Endocannabinoids and non-endocannabinoid fatty acid amides in cirrhosis. | 2010 | Liver Int. | pmid:20408944 |
| Maccarrone M et al. | Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. | 2010 | Neuropsychopharmacology | pmid:20393458 |
| Hoot MR et al. | Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | 2010 | Brain Res. | pmid:20380816 |
| Minkkilä A et al. | Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. | 2010 | Curr Top Med Chem | pmid:20370710 |
| Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
| Frampton G et al. | Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling. | 2010 | Exp. Cell Res. | pmid:20347808 |
| Kvasnicka T | [The endocannabinoid system and interference with thrombogenesis]. | 2010 | Vnitr Lek | pmid:20329583 |
| Muccioli GG | Endocannabinoid biosynthesis and inactivation, from simple to complex. | 2010 | Drug Discov. Today | pmid:20304091 |
| Kozono S et al. | Involvement of the endocannabinoid system in periodontal healing. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20233580 |
| Hurst DP et al. | A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. | 2010 | J. Biol. Chem. | pmid:20220143 |
| Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
| Reggio PH | Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | 2010 | Curr. Med. Chem. | pmid:20166921 |
| Yasuo S et al. | An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes. | 2010 | Cell Tissue Res. | pmid:20165884 |
| Best AR and Regehr WG | Identification of the synthetic pathway producing the endocannabinoid that mediates the bulk of retrograde signaling in the brain. | 2010 | Neuron | pmid:20159441 |
| Arevalo-Martin A et al. | The endocannabinoid 2-arachidonoylglycerol reduces lesion expansion and white matter damage after spinal cord injury. | 2010 | Neurobiol. Dis. | pmid:20156559 |
| Lerner TN et al. | Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 | J. Neurosci. | pmid:20147543 |
| Gao Y et al. | Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. | 2010 | J. Neurosci. | pmid:20147530 |
| Casida JE et al. | S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. | 2010 | Bioorg. Med. Chem. | pmid:20138526 |
| Guida M et al. | The levels of the endocannabinoid receptor CB2 and its ligand 2-arachidonoylglycerol are elevated in endometrial carcinoma. | 2010 | Endocrinology | pmid:20133454 |
| Carrasquer A et al. | Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor. | 2010 | Pharmacogenet. Genomics | pmid:20124950 |
| Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
| Sang N et al. | Anandamide potentiation of miniature spontaneous excitatory synaptic transmission is mediated via IP3 pathway. | 2010 | Neurochem. Int. | pmid:20064571 |
| Eisenstein SA et al. | A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. | 2010 | Pharmacol. Res. | pmid:20044005 |
| Banni S and Di Marzo V | Effect of dietary fat on endocannabinoids and related mediators: consequences on energy homeostasis, inflammation and mood. | 2010 | Mol Nutr Food Res | pmid:20013888 |
| Labar G et al. | Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. | 2010 | Chembiochem | pmid:19957260 |
| Zhang MY et al. | Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. | 2010 | J Mass Spectrom | pmid:19950120 |
| Weis F et al. | Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure. | 2010 | J. Mol. Cell. Cardiol. | pmid:19931541 |
| Marco EM and Viveros MP | The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. | 2009 | Mini Rev Med Chem | pmid:19929814 |
| Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
| Bradshaw H | CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. | 2010 | Pain | pmid:19913999 |
| Telleria-Diaz A et al. | Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. | 2010 | Pain | pmid:19879047 |
| Won YJ et al. | Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. | 2009 | J. Neurosci. | pmid:19864572 |
| Zhang SY et al. | Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. | 2009 | J. Neurosci. | pmid:19846710 |
| Caraceni P et al. | Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. | 2010 | Liver Int. | pmid:19840245 |
| Guindon J and Hohmann AG | The endocannabinoid system and pain. | 2009 | CNS Neurol Disord Drug Targets | pmid:19839937 |
| Maison P et al. | BDNF regulates neuronal sensitivity to endocannabinoids. | 2009 | Neurosci. Lett. | pmid:19818836 |
| Romigi A et al. | Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy. | 2010 | Epilepsia | pmid:19817812 |
| Cobellis G et al. | A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. | 2010 | Biol. Reprod. | pmid:19812302 |
| Gkini E et al. | Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. | 2009 | Platelets | pmid:19811221 |
| Piccinetti CC et al. | Anandamide and AM251, via water, modulate food intake at central and peripheral level in fish. | 2010 | Gen. Comp. Endocrinol. | pmid:19800340 |
| Straiker A et al. | Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. | 2009 | Mol. Pharmacol. | pmid:19767452 |
| Avraham Y et al. | Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. | 2009 | Br. J. Pharmacol. | pmid:19764982 |
| Schroeder C et al. | Circulating endocannabinoid concentrations during orthostatic stress. | 2009 | Clin. Auton. Res. | pmid:19756829 |
| Di Marzo V et al. | Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. | 2009 | Eur. J. Endocrinol. | pmid:19745037 |
| Thors L and Fowler CJ | Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. | 2009 | Eur. J. Pharmacol. | pmid:19715690 |
| Duclos RI | The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1'-(13)C3 and -2,1'-(13)C2 by a novel chemoenzymatic method. | 2010 | Chem. Phys. Lipids | pmid:19682980 |
| Patel S et al. | Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. | 2009 | Neuropsychopharmacology | pmid:19675536 |
| Pan B et al. | Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19666749 |
| Lane JR et al. | The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor. | 2010 | Biochem. Pharmacol. | pmid:19665453 |
| Li Q and Burrell BD | Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. | 2009 | J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. | pmid:19657662 |
| Alvarez-Jaimes L et al. | Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. | 2009 | J. Neurochem. | pmid:19650871 |
| Long JZ et al. | Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. | 2009 | Chem. Biol. | pmid:19635411 |
| Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
| Amorós I et al. | Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner. | 2010 | J. Mol. Cell. Cardiol. | pmid:19616555 |
| Morgan NH et al. | Functional CB2 type cannabinoid receptors at CNS synapses. | 2009 | Neuropharmacology | pmid:19616018 |
| Astarita G et al. | Targeted lipidomics as a tool to investigate endocannabinoid function. | 2009 | Int. Rev. Neurobiol. | pmid:19607960 |
| Prusakiewicz JJ et al. | Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. | 2009 | Biochemistry | pmid:19603831 |
| Wakley AA and Rasmussen EB | Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. | 2009 | Pharmacol. Biochem. Behav. | pmid:19602424 |
| Guasti L et al. | Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. | 2009 | Mol Pain | pmid:19570201 |
| Batetta B et al. | Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. | 2009 | J. Nutr. | pmid:19549757 |
| Bowman AL and Makriyannis A | Refined homology model of monoacylglycerol lipase: toward a selective inhibitor. | 2009 | J. Comput. Aided Mol. Des. | pmid:19543978 |
| Grimaldi P et al. | The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19541620 |
| Maeda N et al. | Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. | 2009 | Fundam Clin Pharmacol | pmid:19527302 |
| Dowie MJ et al. | Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. | 2009 | Neuroscience | pmid:19524019 |
| Greco R et al. | Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat. | 2010 | Cephalalgia | pmid:19515121 |
| Kinsey SG et al. | Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19502530 |
| Straiker A and Mackie K | Cannabinoid signaling in inhibitory autaptic hippocampal neurons. | 2009 | Neuroscience | pmid:19501632 |
| Nyilas R et al. | Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. | 2009 | Eur. J. Neurosci. | pmid:19453631 |
| Ishii Y et al. | F2-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia/reperfusion injury. | 2010 | J. Surg. Res. | pmid:19439322 |
| Hill MN et al. | Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. | 2009 | Psychoneuroendocrinology | pmid:19394765 |
| Yates ML and Barker EL | Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. | 2009 | Mol. Pharmacol. | pmid:19389920 |
| Izzo AA et al. | Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. | 2009 | Br. J. Pharmacol. | pmid:19371345 |
| Urbanski MJ et al. | Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. | 2009 | Synapse | pmid:19347961 |
| Sugiura T | Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2009 Jan-Feb | Biofactors | pmid:19319851 |
| Bermúdez-Silva FJ et al. | The role of the pancreatic endocannabinoid system in glucose metabolism. | 2009 | Best Pract. Res. Clin. Endocrinol. Metab. | pmid:19285263 |
| Bisogno T et al. | Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. | 2009 | ChemMedChem | pmid:19266526 |
| Maccarrone M et al. | Lipid rafts regulate 2-arachidonoylglycerol metabolism and physiological activity in the striatum. | 2009 | J. Neurochem. | pmid:19187444 |
| Schlosburg JE et al. | Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. | 2009 | AAPS J | pmid:19184452 |
| Koppel J et al. | Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. | 2009 | Lipids Health Dis | pmid:19144193 |
| Wang J and Ueda N | Biology of endocannabinoid synthesis system. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19126434 |
| Jiang LS et al. | Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. | 2009 | Cardiovasc. Res. | pmid:19074161 |
| Marinelli S et al. | The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. | 2008 | J. Neurosci. | pmid:19074027 |
| Lehtonen M et al. | Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. | 2008 | Chem. Biodivers. | pmid:19035572 |
| Vignali M et al. | The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. | 2009 | Glia | pmid:19031444 |
| Long JZ et al. | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | 2009 | Nat. Chem. Biol. | pmid:19029917 |
| Bisogno T et al. | Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. | 2009 | Biochim. Biophys. Acta | pmid:19027877 |
| Hill MN et al. | Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. | 2008 | J Neural Transm | pmid:18974922 |
| Di Marzo V et al. | Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. | 2009 | Diabetologia | pmid:18972095 |
| Lu TS et al. | Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. | 2008 | J. Immunol. | pmid:18941231 |
| Garcia-Ovejero D et al. | The endocannabinoid system is modulated in response to spinal cord injury in rats. | 2009 | Neurobiol. Dis. | pmid:18930143 |
| Kreutz S et al. | 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. | 2009 | Glia | pmid:18837048 |
| Ortar G et al. | Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. | 2008 | J. Med. Chem. | pmid:18831576 |
| Catani MV et al. | Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. | 2009 | J. Mol. Med. | pmid:18820887 |
| Bajo M et al. | Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. | 2009 | J. Neurosci. Res. | pmid:18816788 |
| DiPatrizio NV and Simansky KJ | Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. | 2008 | J. Neurosci. | pmid:18815256 |
| Ruby MA et al. | Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18794527 |
| Fowler CJ | "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. | 2008 | Curr. Pharm. Des. | pmid:18781976 |