| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Starvation | D013217 | 47 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Llorente R et al. | Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. | 2008 | Dev Neurobiol | pmid:18666205 |
| Nomura DK et al. | Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18752948 |
| DiPatrizio NV and Simansky KJ | Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. | 2008 | J. Neurosci. | pmid:18815256 |
| Baldassarri S et al. | The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. | 2008 | J. Thromb. Haemost. | pmid:18647220 |
| Ortar G et al. | Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. | 2008 | Eur J Med Chem | pmid:17452063 |
| Shiratsuchi A et al. | Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. | 2008 | Immunol. Cell Biol. | pmid:17909562 |
| Duan Y et al. | Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. | 2008 | Neurochem. Int. | pmid:17888543 |
| Rimmerman N et al. | Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. | 2008 | Br. J. Pharmacol. | pmid:17965731 |
| Hashimotodani Y et al. | Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release. | 2008 | Neuropharmacology | pmid:17655882 |
| Mátyás F et al. | Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. | 2008 | Neuropharmacology | pmid:17655884 |
| Engeli S et al. | Peripheral endocannabinoid system activity in patients treated with sibutramine. | 2008 | Obesity (Silver Spring) | pmid:18356837 |
| Oláh M et al. | The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. | 2008 | Mol. Cell. Endocrinol. | pmid:18308464 |
| Friedman SL and Nieto N | Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. | 2008 | Cell Metab. | pmid:18316020 |
| Jeong WI et al. | Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. | 2008 | Cell Metab. | pmid:18316028 |
| Nomura DK et al. | Activation of the endocannabinoid system by organophosphorus nerve agents. | 2008 | Nat. Chem. Biol. | pmid:18438404 |
| Bisogno T | Endogenous cannabinoids: structure and metabolism. | 2008 | J. Neuroendocrinol. | pmid:18426492 |
| Rubio M et al. | CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | 2008 | Neuropharmacology | pmid:18371990 |
| Di Marzo V and Maccarrone M | FAAH and anandamide: is 2-AG really the odd one out? | 2008 | Trends Pharmacol. Sci. | pmid:18394720 |
| Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
| Richardson D et al. | Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. | 2008 | Arthritis Res. Ther. | pmid:18416822 |
| Ortar G et al. | Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. | 2008 | J. Med. Chem. | pmid:18831576 |
| Palmer JA et al. | Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. | 2008 | Neuroscience | pmid:18541380 |
| Hoover HS et al. | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18657971 |
| Lu TS et al. | Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. | 2008 | J. Immunol. | pmid:18941231 |
| Di Marzo V | Endocannabinoids: synthesis and degradation. | 2008 | Rev. Physiol. Biochem. Pharmacol. | pmid:18481028 |
| Pertwee RG | Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. | 2008 | Addict Biol | pmid:18482430 |
| Di Filippo M et al. | Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. | 2008 | J. Neurol. Neurosurg. Psychiatr. | pmid:18535023 |
| Awumey EM et al. | Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18375719 |
| Hill MN et al. | Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. | 2008 | J Neural Transm | pmid:18974922 |
| Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
| Fowler CJ and Ghafouri N | Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? | 2008 | Pharmacol. Res. | pmid:18675915 |
| Fowler CJ | "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. | 2008 | Curr. Pharm. Des. | pmid:18781976 |
| Placzek EA et al. | Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. | 2008 | J. Neurochem. | pmid:18778304 |
| Placzek EA et al. | Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. | 2008 | Neuropharmacology | pmid:18760289 |
| Qin N et al. | TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 | J. Neurosci. | pmid:18550765 |
| Lehtonen M et al. | Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. | 2008 | Chem. Biodivers. | pmid:19035572 |
| Zhang J and Chen C | Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. | 2008 | J. Biol. Chem. | pmid:18534982 |
| Nabemoto M et al. | Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. | 2008 | Eur. J. Pharmacol. | pmid:18539271 |
| Endsley MP et al. | Expression and function of fatty acid amide hydrolase in prostate cancer. | 2008 | Int. J. Cancer | pmid:18566995 |
| Rockwell CE et al. | A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. | 2008 | Biochem. Pharmacol. | pmid:18571623 |
| Njie YF et al. | Aqueous humor outflow effects of 2-arachidonylglycerol. | 2008 | Exp. Eye Res. | pmid:18597752 |
| Motaghedi R and McGraw TE | The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. | 2008 | Obesity (Silver Spring) | pmid:18551116 |
| Burston JJ et al. | N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18682568 |
| Avraham Y et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771906 |
| Bisogno T et al. | Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. | 2009 | ChemMedChem | pmid:19266526 |
| Kreutz S et al. | 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. | 2009 | Glia | pmid:18837048 |
| Di Marzo V et al. | Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. | 2009 | Diabetologia | pmid:18972095 |
| Won YJ et al. | Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. | 2009 | J. Neurosci. | pmid:19864572 |
| Maison P et al. | BDNF regulates neuronal sensitivity to endocannabinoids. | 2009 | Neurosci. Lett. | pmid:19818836 |
| Gkini E et al. | Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. | 2009 | Platelets | pmid:19811221 |