| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Brain Concussion | D001924 | 5 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Catalepsy | D002375 | 30 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Epilepsy | D004827 | 35 associated lipids |
| Fatty Liver, Alcoholic | D005235 | 11 associated lipids |
| Fragile X Syndrome | D005600 | 5 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Hyperkinesis | D006948 | 11 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shonesy BC et al. | Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. | 2014 | Cell Rep | pmid:25466252 |
| Gasperi V et al. | 2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts. | 2014 | Cell Cycle | pmid:25427281 |
| Zhang J et al. | Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. | 2014 | J. Neurosci. | pmid:25378159 |
| Fezza F et al. | Endocannabinoids, related compounds and their metabolic routes. | 2014 | Molecules | pmid:25347455 |
| Pastor A et al. | Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. | 2014 | J. Lipid Res. | pmid:24610889 |
| Stanley CP and O'Sullivan SE | Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries. | 2014 | Pharmacol. Res. | pmid:24548820 |
| Signorello MG and Leoncini G | Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of phosphatidylinositol 3 kinase/AKT pathway. | 2014 | Biochimie | pmid:25068972 |
| Fernández-Suárez D et al. | Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. | 2014 | Neurobiol. Aging | pmid:24973119 |
| Petrenko AB et al. | Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. | 2014 | Behav. Brain Res. | pmid:24906199 |
| Tsurumura T and Tsuge H | Substrate selectivity of bacterial monoacylglycerol lipase based on crystal structure. | 2014 | J. Struct. Funct. Genomics | pmid:24894647 |
| Alhouayek M et al. | Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. | 2014 | Drug Discov. Today | pmid:23891880 |
| Navarria A et al. | The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis. | 2014 | Pharmacol. Res. | pmid:24861565 |
| Oleson EB et al. | Cannabinoid receptor activation shifts temporally engendered patterns of dopamine release. | 2014 | Neuropsychopharmacology | pmid:24345819 |
| Brantl SA et al. | Activation of platelets by the endocannabinoids 2-arachidonoylglycerol and virodhamine is mediated by their conversion to arachidonic acid and thromboxane A2, not by activation of cannabinoid receptors. | 2014 | Platelets | pmid:24102401 |
| Brantl SA et al. | Mechanism of platelet activation induced by endocannabinoids in blood and plasma. | 2014 | Platelets | pmid:23789792 |
| Iannotti FA et al. | The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24927567 |
| Tiburu EK and Shen L | Distance measurements and conformational analysis of sn-2-arachidonoylglycerol-membrane sample by ²H-³¹P REDOR NMR. | 2014 | J. Membr. Biol. | pmid:24402242 |
| Costa MA et al. | 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. | 2014 | Reproduction | pmid:24324206 |
| Pertwee RG | Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications. | 2014 | Proc Nutr Soc | pmid:24135210 |
| Yang K et al. | Differential regulation of NMDAR and NMDAR-mediated metaplasticity by anandamide and 2-AG in the hippocampus. | 2014 | Hippocampus | pmid:25087967 |
| Fezza F et al. | Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. | 2014 | Mol. Cell. Neurosci. | pmid:25064144 |
| Pava MJ et al. | Endocannabinoid modulation of cortical up-states and NREM sleep. | 2014 | PLoS ONE | pmid:24520411 |
| Sanson B et al. | Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. | 2014 | Acta Crystallogr. D Biol. Crystallogr. | pmid:24531463 |
| Limebeer CL et al. | Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system. | 2014 | Psychopharmacology (Berl.) | pmid:24043345 |
| Pascual AC et al. | Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | 2013 Mar-Apr | Biofactors | pmid:23281018 |
| Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
| Fagundo AB et al. | Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. | 2013 | PLoS ONE | pmid:23840456 |
| Jäntti MH et al. | Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. | 2013 | Mol. Pharmacol. | pmid:23233488 |
| Su LD et al. | Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. | 2013 | Cerebellum | pmid:23307660 |
| Keimpema E et al. | Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23319656 |
| Shimizu T et al. | Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. | 2013 | J. Pharmacol. Sci. | pmid:23386378 |
| Tchantchou F and Zhang Y | Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. | 2013 | J. Neurotrauma | pmid:23151067 |
| Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
| Neumeister A et al. | Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. | 2013 | Mol. Psychiatry | pmid:23670490 |
| Jain T et al. | Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. | 2013 | Mol. Pharmacol. | pmid:23748223 |
| Citraro R et al. | Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. | 2013 | Neuropharmacology | pmid:23206503 |
| Frazier CJ | Preformed vs. on-demand: molecular economics of endocannabinoid signalling. | 2013 | J. Physiol. (Lond.) | pmid:24085490 |
| Descalzi F et al. | Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. | 2013 | Tissue Eng Part A | pmid:23578218 |
| Morgan CJ et al. | Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms. | 2013 | Br J Psychiatry | pmid:23580381 |
| Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
| Berge K et al. | Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. | 2013 | Lipids Health Dis | pmid:23706001 |
| Zygmunt PM et al. | Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. | 2013 | PLoS ONE | pmid:24312564 |
| Wang R et al. | Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. | 2013 | Biochemistry | pmid:24083319 |
| Ikeda H et al. | Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. | 2013 | Neuroscience | pmid:23892011 |
| Yuan S and Burrell BD | Nonnociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism. | 2013 | J. Neurophysiol. | pmid:24027102 |
| Hill MN et al. | Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. | 2013 | Psychoneuroendocrinology | pmid:24035186 |
| Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
| Malenczyk K et al. | CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. | 2013 | J. Biol. Chem. | pmid:24089517 |
| Brocato B et al. | Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. | 2013 | Placenta | pmid:24008071 |
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