| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Hepatic Encephalopathy | D006501 | 9 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Peripheral Nervous System Diseases | D010523 | 33 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Starvation | D013217 | 47 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zou Z et al. | Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. | 2016 | J. Mol. Neurosci. | pmid:27129498 |
| Keyshams N et al. | Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors. | 2016 | Vet. Res. Commun. | pmid:27000110 |
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| Liu X et al. | Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. | 2016 | Sci Rep | pmid:27775008 |
| Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
| Reddy IA et al. | Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. | 2016 | Transl Psychiatry | pmid:27187231 |
| Gray JM et al. | Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. | 2016 | Psychoneuroendocrinology | pmid:26821211 |
| Martella A et al. | Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. | 2016 | Endocrinology | pmid:27014939 |
| Leishman E et al. | Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. | 2016 | Pharmacol. Res. | pmid:27109320 |
| Di S et al. | Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. | 2016 | J. Neurosci. | pmid:27511017 |
| Vujic N et al. | Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. | 2016 | Atherosclerosis | pmid:26584135 |
| Mann A et al. | Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? | 2016 | J Basic Clin Physiol Pharmacol | pmid:26565551 |
| Grabner GF et al. | Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. | 2016 | J. Biol. Chem. | pmid:26565024 |
| Sticht MA et al. | Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. | 2016 | Neuropharmacology | pmid:26541329 |
| Bisogno T | Assay of DAGLα/β Activity. | 2016 | Methods Mol. Biol. | pmid:27245901 |
| Battista N and Sergi M | Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. | 2016 | Methods Mol. Biol. | pmid:27245888 |
| Liisberg U et al. | Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. | 2016 | J. Nutr. Biochem. | pmid:27155918 |
| Midtbø LK et al. | Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. | 2015 | J. Nutr. Biochem. | pmid:25776459 |
| Niki M et al. | Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. | 2015 | J. Physiol. (Lond.) | pmid:25728242 |
| Bashashati M et al. | Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation. | 2015 | Br. J. Pharmacol. | pmid:25684407 |
| Schaich CL et al. | Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. | 2015 | J. Cardiovasc. Pharmacol. | pmid:25636077 |
| Belluomo I et al. | Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes. | 2015 | J. Neurochem. | pmid:25626460 |
| Smith M et al. | The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. | 2015 | PLoS ONE | pmid:26414859 |
| Altamura C et al. | Elevation of Plasma 2-Arachidonoylglycerol Levels in Alzheimer's Disease Patients as a Potential Protective Mechanism against Neurodegenerative Decline. | 2015 | J. Alzheimers Dis. | pmid:25818503 |
| Lecru L et al. | Cannabinoid receptor 1 is a major mediator of renal fibrosis. | 2015 | Kidney Int. | pmid:25760323 |
| Mann A et al. | Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. | 2015 | J Neuroimmune Pharmacol | pmid:25721934 |
| Marcaggi P | Cerebellar endocannabinoids: retrograde signaling from purkinje cells. | 2015 | Cerebellum | pmid:25520276 |
| Szekeres M et al. | Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. | 2015 | Mol. Cell. Endocrinol. | pmid:25595485 |
| Li B et al. | Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. | 2015 | Toxicol. Sci. | pmid:26209559 |
| Patsenker E et al. | Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. | 2015 | Int J Mol Sci | pmid:25826533 |
| Ivanov I et al. | A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. | 2015 | Anal Bioanal Chem | pmid:25519724 |
| Walentiny DM et al. | Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice. | 2015 | Neuropharmacology | pmid:25698527 |
| Monteleone AM et al. | Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa. | 2015 | Am. J. Clin. Nutr. | pmid:25646322 |
| Gaskari SA et al. | Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids. | 2015 | J. Hepatol. | pmid:25640062 |
| Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
| Llorente-Berzal A et al. | 2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons. | 2015 | Psychopharmacology (Berl.) | pmid:25814137 |
| Pisanti S et al. | Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. | 2015 | J. Cell. Physiol. | pmid:25684344 |
| Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
| Urquhart P et al. | Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. | 2015 | Biochim. Biophys. Acta | pmid:25543004 |
| Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
| Orellana-Serradell O et al. | Proapoptotic effect of endocannabinoids in prostate cancer cells. | 2015 | Oncol. Rep. | pmid:25606819 |
| Wollank Y et al. | Inhibition of FAAH confers increased stem cell migration via PPARα. | 2015 | J. Lipid Res. | pmid:26263913 |
| Zheng G et al. | Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. | 2015 | Exp. Neurol. | pmid:26408049 |
| Szafran B et al. | Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26403860 |
| Mitchener MM et al. | Competition and allostery govern substrate selectivity of cyclooxygenase-2. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26392530 |
| Wang H et al. | Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. | 2015 | Cell Rep | pmid:26365195 |
| Ho WS et al. | Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. | 2015 | Br. J. Pharmacol. | pmid:26294342 |
| DiPatrizio NV et al. | Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26290104 |
| Mounsey RB et al. | Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. | 2015 | Exp. Neurol. | pmid:26244281 |
| Liu Z et al. | Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice. | 2015 | Sci Rep | pmid:25830356 |