2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fagundo AB et al. | Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans. | 2013 | PLoS ONE | pmid:23840456 |
Chiou LC et al. | Targeting the cannabinoid system for pain relief? | 2013 | Acta Anaesthesiol Taiwan | pmid:24529672 |
Cristino L et al. | Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23630288 |
Barricklow J and Blatnik M | 2-Arachidonoylglycerol is a substrate for butyrylcholinesterase: A potential mechanism for extracellular endocannabinoid regulation. | 2013 | Arch. Biochem. Biophys. | pmid:23689009 |
Bari M et al. | In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. | 2013 | FEBS J. | pmid:23659592 |
Chouinard F et al. | 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV. | 2013 | J. Leukoc. Biol. | pmid:23242611 |
Rivera P et al. | Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23217608 |
Valdeolivas S et al. | The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG. | 2013 | Cell Death Dis | pmid:24136226 |
Jäntti MH et al. | Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. | 2013 | Mol. Pharmacol. | pmid:23233488 |
Su LD et al. | Retrograde cPLA2α/arachidonic acid/2-AG signaling is essential for cerebellar depolarization-induced suppression of excitation and long-term potentiation. | 2013 | Cerebellum | pmid:23307660 |
Keimpema E et al. | Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23319656 |
Shimizu T et al. | Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats. | 2013 | J. Pharmacol. Sci. | pmid:23386378 |
Tchantchou F and Zhang Y | Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. | 2013 | J. Neurotrauma | pmid:23151067 |
Alhouayek M et al. | Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24101490 |
Iannotti FA et al. | Analysis of the "endocannabinoidome" in peripheral tissues of obese Zucker rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23830028 |
Citraro R et al. | Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy. | 2013 | Neuropharmacology | pmid:23206503 |
Hashimotodani Y et al. | Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol. | 2013 | J. Physiol. (Lond.) | pmid:23858009 |
Kerr DM et al. | The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action. | 2013 | Br. J. Pharmacol. | pmid:23043675 |
Lindgren CA et al. | Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction. | 2013 | J. Physiol. (Lond.) | pmid:23818695 |
Frazier CJ | Preformed vs. on-demand: molecular economics of endocannabinoid signalling. | 2013 | J. Physiol. (Lond.) | pmid:24085490 |
Descalzi F et al. | Platelet-rich plasma exerts antinociceptive activity by a peripheral endocannabinoid-related mechanism. | 2013 | Tissue Eng Part A | pmid:23578218 |
Bisogno T et al. | A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. | 2013 | Br. J. Pharmacol. | pmid:23072382 |
Berge K et al. | Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men. | 2013 | Lipids Health Dis | pmid:23706001 |
Zygmunt PM et al. | Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. | 2013 | PLoS ONE | pmid:24312564 |
Wang R et al. | Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. | 2013 | Biochemistry | pmid:24083319 |
Ikeda H et al. | Activation of spinal cannabinoid CB2 receptors inhibits neuropathic pain in streptozotocin-induced diabetic mice. | 2013 | Neuroscience | pmid:23892011 |
Ilayan E et al. | Do cannabinoids exhibit a tyramine-like effect? | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23900610 |
Krumbholz A et al. | Diagnostic value of concentration profiles of glucocorticosteroids and endocannabinoids in hair. | 2013 | Ther Drug Monit | pmid:23942543 |
Hill MN et al. | Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. | 2013 | Psychoneuroendocrinology | pmid:24035186 |
Bernabò N et al. | Systems biology analysis of the endocannabinoid system reveals a scale-free network with distinct roles for anandamide and 2-arachidonoylglycerol. | 2013 | OMICS | pmid:24117401 |
Gesell FK et al. | Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. | 2013 | BMC Vet. Res. | pmid:24370333 |
Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
Malenczyk K et al. | CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. | 2013 | J. Biol. Chem. | pmid:24089517 |
Brocato B et al. | Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. | 2013 | Placenta | pmid:24008071 |
Fonseca BM et al. | Endogenous cannabinoids revisited: a biochemistry perspective. | 2013 Apr-May | Prostaglandins Other Lipid Mediat. | pmid:23474290 |
Pascual AC et al. | Aging modifies the enzymatic activities involved in 2-arachidonoylglycerol metabolism. | 2013 Mar-Apr | Biofactors | pmid:23281018 |
Nithipatikom K et al. | A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol. | 2014 | J. Lipid Res. | pmid:24958911 |
Lu Y et al. | Endocannabinoid 2-arachidonylglycerol protects primary cultured neurons against LPS-induced impairments in rat caudate nucleus. | 2014 | J. Mol. Neurosci. | pmid:24510751 |
Lau BK et al. | Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey. | 2014 | Br. J. Pharmacol. | pmid:25041240 |
Laprairie RB et al. | Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. | 2014 | J. Biol. Chem. | pmid:25037227 |
Cipriano M et al. | The influence of monoacylglycerol lipase inhibition upon the expression of epidermal growth factor receptor in human PC-3 prostate cancer cells. | 2014 | BMC Res Notes | pmid:25012825 |
Larose MC et al. | Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. | 2014 | J. Allergy Clin. Immunol. | pmid:24530098 |
Abdulnour J et al. | Circulating endocannabinoids in insulin sensitive vs. insulin resistant obese postmenopausal women. A MONET group study. | 2014 | Obesity (Silver Spring) | pmid:23616305 |
Melis M et al. | Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. | 2014 | J. Neurosci. | pmid:25232109 |
Murataeva N et al. | Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. | 2014 | Br. J. Pharmacol. | pmid:24102242 |
Yasuo S et al. | 2-Arachidonoyl glycerol sensitizes the pars distalis and enhances forskolin-stimulated prolactin secretion in Syrian hamsters. | 2014 | Chronobiol. Int. | pmid:24200164 |
Pulgar VM et al. | Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. | 2014 | Hypertension | pmid:24935942 |
Rea K et al. | Microinjection of 2-arachidonoyl glycerol into the rat ventral hippocampus differentially modulates contextually induced fear, depending on a persistent pain state. | 2014 | Eur. J. Neurosci. | pmid:24494683 |
Zheng Y et al. | Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system. | 2014 | Eur. J. Pharmacol. | pmid:24508383 |
Krishnan G and Chatterjee N | Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. | 2014 | Mol. Cell. Neurosci. | pmid:24418364 |