2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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van der Stelt M et al. | A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. | 2005 | FASEB J. | pmid:15894565 |
Lambert DM and Fowler CJ | The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. | 2005 | J. Med. Chem. | pmid:16078824 |
Venderova K et al. | Differential effects of endocannabinoids on [(3)H]-GABA uptake in the rat globus pallidus. | 2005 | Exp. Neurol. | pmid:15899265 |
Hohmann AG et al. | An endocannabinoid mechanism for stress-induced analgesia. | 2005 | Nature | pmid:15973410 |
Julien B et al. | Antifibrogenic role of the cannabinoid receptor CB2 in the liver. | 2005 | Gastroenterology | pmid:15765409 |
Chen J et al. | Finding of endocannabinoids in human eye tissues: implications for glaucoma. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15823551 |
Straiker A and Mackie K | Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. | 2005 | J. Physiol. (Lond.) | pmid:16179366 |
Maccarrone M et al. | Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. | 2005 | Mol. Hum. Reprod. | pmid:15563449 |
Rademacher DJ et al. | Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas). | 2005 | Neurotoxicology | pmid:15527869 |
Shoemaker JL et al. | Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16081674 |
Sipe JC et al. | Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders. | 2005 | J. Leukoc. Biol. | pmid:15845647 |
Jung KM et al. | Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. | 2005 | Mol. Pharmacol. | pmid:16051747 |
Makara JK et al. | Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. | 2005 | Nat. Neurosci. | pmid:16116451 |
Secko D | Analgesia through endogenous cannabinoids. | 2005 | CMAJ | pmid:16103504 |
Maejima T et al. | Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum. | 2005 | J. Neurosci. | pmid:16033892 |
Panikashvili D et al. | CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibition. | 2005 | J. Cereb. Blood Flow Metab. | pmid:15729296 |
Gopez JJ et al. | Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. | 2005 | Neurosurgery | pmid:15730585 |
Zhao Q et al. | 2-Arachidonoylglycerol stimulates activator protein-1-dependent transcriptional activity and enhances epidermal growth factor-induced cell transformation in JB6 P+ cells. | 2005 | J. Biol. Chem. | pmid:15886210 |
Rouzer CA and Marnett LJ | Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus. | 2005 | J. Biol. Chem. | pmid:15917246 |
Nithipatikom K et al. | A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15919052 |
Gauthier KM et al. | Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15528233 |
Gabbay E et al. | Endocannabinoids and liver disease--review. | 2005 | Liver Int. | pmid:16162147 |
Vandevoorde S et al. | Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16181610 |
Ramos JA et al. | Therapeutic potential of the endocannabinoid system in the brain. | 2005 | Mini Rev Med Chem | pmid:16026307 |
Kim J and Alger BE | Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus. | 2004 | Nat. Neurosci. | pmid:15184902 |
Witting A et al. | Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice. | 2004 | J. Neurochem. | pmid:15189359 |
Stanke-Labesque F et al. | 2-Arachidonoyl glycerol induces contraction of isolated rat aorta: role of cyclooxygenase-derived products. | 2004 | Cardiovasc. Res. | pmid:15194472 |
Oka S et al. | 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils. | 2004 | J. Leukoc. Biol. | pmid:15316028 |
Nithipatikom K et al. | 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. | 2004 | Cancer Res. | pmid:15604240 |
González S et al. | Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence. | 2004 | Drug Alcohol Depend | pmid:15099659 |
Valenti M et al. | Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain. | 2004 | Cell. Mol. Life Sci. | pmid:15095014 |
Kishimoto S et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. | 2004 | J. Biochem. | pmid:15115777 |
Hájos N et al. | Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: effects of low temperature and the transport inhibitor AM404. | 2004 | Eur. J. Neurosci. | pmid:15182306 |
Vannacci A et al. | The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15187170 |
Maestroni GJ | The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein. | 2004 | FASEB J. | pmid:15385435 |
Walter L et al. | ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. | 2004 | J. Neurosci. | pmid:15371507 |
Dinh TP et al. | RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. | 2004 | Mol. Pharmacol. | pmid:15272052 |
Malorni W et al. | Morphological evidence that 2-arachidonoylglycerol is a true agonist of human platelets. | 2004 | Thromb. Haemost. | pmid:15543349 |
Melis M et al. | Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. | 2004 | J. Neurosci. | pmid:15564588 |
Sugiura T et al. | New perspectives in the studies on endocannabinoid and cannabis: 2-arachidonoylglycerol as a possible novel mediator of inflammation. | 2004 | J. Pharmacol. Sci. | pmid:15599096 |
Saario SM et al. | Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. | 2004 | Biochem. Pharmacol. | pmid:15013854 |
Alberich Jordà M et al. | The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner. | 2004 | Blood | pmid:15039279 |
Witting A et al. | P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14976257 |
Carrier EJ et al. | Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. | 2004 | Mol. Pharmacol. | pmid:15044630 |
Golech SA et al. | Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. | 2004 | Brain Res. Mol. Brain Res. | pmid:15548432 |
Mukherjee S et al. | Species comparison and pharmacological characterization of rat and human CB2 cannabinoid receptors. | 2004 | Eur. J. Pharmacol. | pmid:15556131 |
Guo J and Ikeda SR | Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. | 2004 | Mol. Pharmacol. | pmid:14978245 |
Piomelli D | The endogenous cannabinoid system and the treatment of marijuana dependence. | 2004 | Neuropharmacology | pmid:15464150 |
Ghafouri N et al. | Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. | 2004 | Br. J. Pharmacol. | pmid:15492019 |
Motobe T et al. | Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. | 2004 | Shock | pmid:14676677 |