2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Brosnihan KB et al. | Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. | 2015 | Reprod. Biol. Endocrinol. | pmid:25596750 |
Griebel G et al. | Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. | 2015 | Sci Rep | pmid:25560837 |
Zhang J et al. | Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25492114 |
Shonesy BC et al. | The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. | 2015 | Neuropharmacology | pmid:25484252 |
Marcaggi P | Cerebellar endocannabinoids: retrograde signaling from purkinje cells. | 2015 | Cerebellum | pmid:25520276 |
Mennella I et al. | Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans. | 2015 | J. Nutr. | pmid:26180248 |
Li B et al. | Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPARγ Pathway. | 2015 | Toxicol. Sci. | pmid:26209559 |
Ivanov I et al. | A simple method for simultaneous determination of N-arachidonoylethanolamine, N-oleoylethanolamine, N-palmitoylethanolamine and 2-arachidonoylglycerol in human cells. | 2015 | Anal Bioanal Chem | pmid:25519724 |
Scotchie JG et al. | Endocannabinoid regulation in human endometrium across the menstrual cycle. | 2015 | Reprod Sci | pmid:24819878 |
Pasquarelli N et al. | Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. | 2015 | Neuropharmacology | pmid:25497453 |
Aliczki M et al. | Involvement of 2-arachidonoylglycerol signaling in social challenge responding of male CD1 mice. | 2015 | Psychopharmacology (Berl.) | pmid:25547462 |
Urquhart P et al. | Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases. | 2015 | Biochim. Biophys. Acta | pmid:25543004 |
Liu J et al. | Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. | 2015 | Neurotoxicology | pmid:26215119 |
Ford GK et al. | Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats. | 2015 | Eur J Pain | pmid:25504741 |
Sticht MA et al. | Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats. | 2015 | Neuroscience | pmid:25499318 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Anderson GR et al. | β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. | 2015 | Cell | pmid:26213384 |
Viader A et al. | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. | 2015 | Cell Rep | pmid:26212325 |
Straiker A et al. | Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. | 2015 | Pharmacol. Res. | pmid:26211948 |
Kita Y et al. | Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. | 2015 | PLoS ONE | pmid:26196692 |