2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lourenço J et al. | Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. | 2010 | Nat. Neurosci. | pmid:20081851 |
Puente N et al. | Polymodal activation of the endocannabinoid system in the extended amygdala. | 2011 | Nat. Neurosci. | pmid:22057189 |
Self DW | Anandamide: a candidate neurotransmitter heads for the big leagues. | 1999 | Nat. Neurosci. | pmid:10204533 |
Shonesy BC et al. | CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling. | 2013 | Nat. Neurosci. | pmid:23502535 |
Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
Maccarrone M et al. | Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. | 2008 | Nat. Neurosci. | pmid:18204441 |
Di Marzo V | Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight. | 2011 | Nat. Neurosci. | pmid:21187849 |
Makara JK et al. | Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. | 2005 | Nat. Neurosci. | pmid:16116451 |
Marrs WR et al. | The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. | 2010 | Nat. Neurosci. | pmid:20657592 |
Duggan KC et al. | (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. | 2011 | Nat. Chem. Biol. | pmid:22053353 |
Hsu KL et al. | DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. | 2012 | Nat. Chem. Biol. | pmid:23103940 |
Nomura DK et al. | Activation of the endocannabinoid system by organophosphorus nerve agents. | 2008 | Nat. Chem. Biol. | pmid:18438404 |
Long JZ et al. | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | 2009 | Nat. Chem. Biol. | pmid:19029917 |
Flores-Otero J et al. | Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. | 2014 | Nat Commun | pmid:25081814 |
Bluett RJ et al. | Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. | 2017 | Nat Commun | pmid:28348378 |
Tung LW et al. | Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. | 2016 | Nat Commun | pmid:27448020 |
Jung KM et al. | Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. | 2012 | Nat Commun | pmid:23011134 |
Alpár A et al. | Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. | 2014 | Nat Commun | pmid:25030704 |
Iannotti FA et al. | Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. | 2018 | Nat Commun | pmid:30262909 |
Fezza F et al. | Endocannabinoids, related compounds and their metabolic routes. | 2014 | Molecules | pmid:25347455 |
Szafran BN et al. | Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. | 2018 | Molecules | pmid:30513753 |
Muccioli GG et al. | The endocannabinoid system links gut microbiota to adipogenesis. | 2010 | Mol. Syst. Biol. | pmid:20664638 |
Neumeister A et al. | Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. | 2013 | Mol. Psychiatry | pmid:23670490 |
Rockwell CE et al. | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | 2006 | Mol. Pharmacol. | pmid:16611855 |
Raman P et al. | 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. | 2011 | Mol. Pharmacol. | pmid:21511917 |
Yates ML and Barker EL | Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. | 2009 | Mol. Pharmacol. | pmid:19389920 |
Jung KM et al. | A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. | 2007 | Mol. Pharmacol. | pmid:17584991 |
Jäntti MH et al. | Autocrine endocannabinoid signaling through CB1 receptors potentiates OX1 orexin receptor signaling. | 2013 | Mol. Pharmacol. | pmid:23233488 |
Dinh TP et al. | RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. | 2004 | Mol. Pharmacol. | pmid:15272052 |
He F et al. | Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. | 2007 | Mol. Pharmacol. | pmid:17698952 |
Jain T et al. | Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. | 2013 | Mol. Pharmacol. | pmid:23748223 |
Lichtman AH et al. | Endocannabinoid overload. | 2010 | Mol. Pharmacol. | pmid:20952498 |
Gonsiorek W et al. | Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide. | 2000 | Mol. Pharmacol. | pmid:10779390 |
Carrier EJ et al. | Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. | 2004 | Mol. Pharmacol. | pmid:15044630 |
Laitinen T et al. | Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. | 2014 | Mol. Pharmacol. | pmid:24368842 |
Jung KM et al. | Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. | 2005 | Mol. Pharmacol. | pmid:16051747 |
Straiker A et al. | Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. | 2009 | Mol. Pharmacol. | pmid:19767452 |
Ouyang Y et al. | Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells. | 1998 | Mol. Pharmacol. | pmid:9547358 |
Guo J and Ikeda SR | Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. | 2004 | Mol. Pharmacol. | pmid:14978245 |
Delgado-Peraza F et al. | Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. | 2016 | Mol. Pharmacol. | pmid:27009233 |
van der Stelt M et al. | Acute neuronal injury, excitotoxicity, and the endocannabinoid system. | 2002 Oct-Dec | Mol. Neurobiol. | pmid:12428763 |
Luchicchi A and Pistis M | Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids. | 2012 | Mol. Neurobiol. | pmid:22801993 |
Patsenker E et al. | Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. | 2011 | Mol. Med. | pmid:21863215 |
Maccarrone M et al. | Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility. | 2005 | Mol. Hum. Reprod. | pmid:15563449 |
Xu C et al. | Endocannabinoids exert CB receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein. | 2017 | Mol. Cell. Neurosci. | pmid:28733129 |
Fezza F et al. | Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting. | 2014 | Mol. Cell. Neurosci. | pmid:25064144 |
Krishnan G and Chatterjee N | Endocannabinoids affect innate immunity of Muller glia during HIV-1 Tat cytotoxicity. | 2014 | Mol. Cell. Neurosci. | pmid:24418364 |
Battista N et al. | The role of endocannabinoids in gonadal function and fertility along the evolutionary axis. | 2012 | Mol. Cell. Endocrinol. | pmid:22305972 |
Szekeres M et al. | Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. | 2015 | Mol. Cell. Endocrinol. | pmid:25595485 |
Catanzaro G et al. | Effect of capacitation on the endocannabinoid system of mouse sperm. | 2011 | Mol. Cell. Endocrinol. | pmid:21723369 |