2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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D'Argenio G et al. | Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. | 2007 | J. Mol. Med. | pmid:17396241 |
Rubio M et al. | Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. | 2007 | Neurosci. Lett. | pmid:17574742 |
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Karsak M et al. | Attenuation of allergic contact dermatitis through the endocannabinoid system. | 2007 | Science | pmid:17556587 |
Endsley MP et al. | Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. | 2007 | Int. J. Cancer | pmid:17443494 |
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Adermark L and Lovinger DM | Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077376 |
Sang N et al. | COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. | 2007 | J. Neurochem. | pmid:17539917 |
Jung KM et al. | A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. | 2007 | Mol. Pharmacol. | pmid:17584991 |
Béquet F et al. | CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. | 2007 | Eur. J. Neurosci. | pmid:18052990 |
Siegmund SV et al. | The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. | 2007 | FASEB J. | pmid:17440119 |
Uchigashima M et al. | Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. | 2007 | J. Neurosci. | pmid:17409230 |
Lafourcade M et al. | Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. | 2007 | PLoS ONE | pmid:17684555 |
Gokoh M et al. | 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. | 2007 | Biol. Pharm. Bull. | pmid:17603153 |
Cisneros JA et al. | Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. | 2007 | J. Med. Chem. | pmid:17764163 |
Degn M et al. | Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice. | 2007 | J. Neurochem. | pmid:17868306 |
Sugiura T | [2-Arachidonoylglycerol: an endogenous cannabinoid receptor ligand]. | 2007 | Seikagaku | pmid:17763698 |
Smid SD et al. | The endocannabinoids anandamide and 2-arachidonoylglycerol inhibit cholinergic contractility in the human colon. | 2007 | Eur. J. Pharmacol. | pmid:17706636 |
He F et al. | Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. | 2007 | Mol. Pharmacol. | pmid:17698952 |
Saario SM and Laitinen JT | Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol. | 2007 | Chem. Biodivers. | pmid:17712832 |
Ho WS and Randall MD | Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. | 2007 | Br. J. Pharmacol. | pmid:17245358 |
Vadivel SK et al. | Conformationally constrained analogues of 2-arachidonoylglycerol. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17826996 |
Yu Y et al. | Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. | 2007 | J. Biol. Chem. | pmid:17110378 |
Straiker A and Mackie K | Metabotropic suppression of excitation in murine autaptic hippocampal neurons. | 2007 | J. Physiol. (Lond.) | pmid:17110416 |
Blankman JL et al. | A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. | 2007 | Chem. Biol. | pmid:18096503 |
Guindon J et al. | The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. | 2007 | Br. J. Pharmacol. | pmid:17179944 |
Scutt A and Williamson EM | Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. | 2007 | Calcif. Tissue Int. | pmid:17205329 |
Imming P | Fatty pain cures. | 2007 | Chem. Biol. | pmid:18096498 |
King AR et al. | URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. | 2007 | Chem. Biol. | pmid:18096504 |
Opitz CA et al. | Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells. | 2007 | FEBS Lett. | pmid:17904123 |
Mukhopadhyay S and Tulis DA | Endocannabinoid regulation of matrix metalloproteinases: implications in ischemic stroke. | 2007 | Cardiovasc Hematol Agents Med Chem | pmid:17979695 |
Soria-Gómez E et al. | Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. | 2007 | Br. J. Pharmacol. | pmid:17549045 |
Dainese E et al. | Modulation of the endocannabinoid system by lipid rafts. | 2007 | Curr. Med. Chem. | pmid:17979719 |
Matias I et al. | Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011761 |
Bari M et al. | Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. | 2006 | J. Immunol. | pmid:17015679 |
Spoto B et al. | Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. | 2006 | Biochimie | pmid:16949718 |
Wagner JA et al. | 2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16775503 |
Quistad GB et al. | Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16310817 |
van der Stelt M et al. | Endocannabinoids and beta-amyloid-induced neurotoxicity in vivo: effect of pharmacological elevation of endocannabinoid levels. | 2006 | Cell. Mol. Life Sci. | pmid:16732431 |
Panikashvili D et al. | The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. | 2006 | Neurobiol. Dis. | pmid:16364651 |
Parkkari T et al. | Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE). | 2006 | Bioorg. Med. Chem. | pmid:16403642 |
Saario SM et al. | URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. | 2006 | Chem. Biol. | pmid:16931330 |
Sang N et al. | PGE2 glycerol ester, a COX-2 oxidative metabolite of 2-arachidonoyl glycerol, modulates inhibitory synaptic transmission in mouse hippocampal neurons. | 2006 | J. Physiol. (Lond.) | pmid:16484297 |
Parkkari T et al. | Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16466915 |
Kurihara R et al. | Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils. | 2006 | J. Biol. Chem. | pmid:16513651 |
Mestre L et al. | The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection. | 2006 | Biochem. Pharmacol. | pmid:16914119 |
Blüher M et al. | Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. | 2006 | Diabetes | pmid:17065342 |