2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Marrs W and Stella N | 2-AG + 2 new players = forecast for therapeutic advances. | 2007 | Chem. Biol. | pmid:18096497 |
Ryberg E et al. | The orphan receptor GPR55 is a novel cannabinoid receptor. | 2007 | Br. J. Pharmacol. | pmid:17876302 |
Hohmann AG | Inhibitors of monoacylglycerol lipase as novel analgesics. | 2007 | Br. J. Pharmacol. | pmid:17293886 |
Palomäki VA et al. | Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography. | 2007 | J. Neurochem. | pmid:17254014 |
Muccioli GG et al. | Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. | 2007 | J. Neurosci. | pmid:17360910 |
Labar G et al. | Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. | 2007 | Chembiochem | pmid:17579916 |
Wang H et al. | Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259073 |
Adermark L and Lovinger DM | Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18077376 |
Sang N et al. | COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. | 2007 | J. Neurochem. | pmid:17539917 |
Jung KM et al. | A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. | 2007 | Mol. Pharmacol. | pmid:17584991 |
Béquet F et al. | CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus. | 2007 | Eur. J. Neurosci. | pmid:18052990 |
Siegmund SV et al. | The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species. | 2007 | FASEB J. | pmid:17440119 |
Uchigashima M et al. | Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. | 2007 | J. Neurosci. | pmid:17409230 |
Lafourcade M et al. | Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. | 2007 | PLoS ONE | pmid:17684555 |
Gokoh M et al. | 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. | 2007 | Biol. Pharm. Bull. | pmid:17603153 |
Sarchielli P et al. | Endocannabinoids in chronic migraine: CSF findings suggest a system failure. | 2007 | Neuropsychopharmacology | pmid:17119542 |
Degn M et al. | Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice. | 2007 | J. Neurochem. | pmid:17868306 |
Sugiura T | [2-Arachidonoylglycerol: an endogenous cannabinoid receptor ligand]. | 2007 | Seikagaku | pmid:17763698 |
He F et al. | Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. | 2007 | Mol. Pharmacol. | pmid:17698952 |
Rossi G et al. | Follicle-stimulating hormone activates fatty acid amide hydrolase by protein kinase A and aromatase-dependent pathways in mouse primary Sertoli cells. | 2007 | Endocrinology | pmid:17110429 |
Ho WS and Randall MD | Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. | 2007 | Br. J. Pharmacol. | pmid:17245358 |
Deshpande LS et al. | Endocannabinoids block status epilepticus in cultured hippocampal neurons. | 2007 | Eur. J. Pharmacol. | pmid:17174949 |
Kreutz S et al. | Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures. | 2007 | Exp. Neurol. | pmid:17010339 |
Suhara Y et al. | Synthesis and biological evaluation of several structural analogs of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2007 | Bioorg. Med. Chem. | pmid:17110113 |
Yu Y et al. | Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. | 2007 | J. Biol. Chem. | pmid:17110378 |
Straiker A and Mackie K | Metabotropic suppression of excitation in murine autaptic hippocampal neurons. | 2007 | J. Physiol. (Lond.) | pmid:17110416 |
Blankman JL et al. | A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. | 2007 | Chem. Biol. | pmid:18096503 |
Guindon J et al. | The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. | 2007 | Br. J. Pharmacol. | pmid:17179944 |
Imming P | Fatty pain cures. | 2007 | Chem. Biol. | pmid:18096498 |
King AR et al. | URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. | 2007 | Chem. Biol. | pmid:18096504 |
Dainese E et al. | Modulation of the endocannabinoid system by lipid rafts. | 2007 | Curr. Med. Chem. | pmid:17979719 |
Fan SF and Yazulla S | Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol. | 2007 May-Jun | Vis. Neurosci. | pmid:17592669 |
Sakamoto Y et al. | Clinical responses and improvement of some laboratory parameters following polymyxin B-immobilized fiber treatment in septic shock. | 2007 Sep-Oct | ASAIO J. | pmid:17885340 |
Llorente R et al. | Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. | 2008 | Dev Neurobiol | pmid:18666205 |
Nomura DK et al. | Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18752948 |
DiPatrizio NV and Simansky KJ | Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. | 2008 | J. Neurosci. | pmid:18815256 |
Baldassarri S et al. | The endocannabinoid 2-arachidonoylglycerol activates human platelets through non-CB1/CB2 receptors. | 2008 | J. Thromb. Haemost. | pmid:18647220 |
Ortar G et al. | Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. | 2008 | Eur J Med Chem | pmid:17452063 |
Shiratsuchi A et al. | Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. | 2008 | Immunol. Cell Biol. | pmid:17909562 |
Duan Y et al. | Inhibition of [3H]batrachotoxinin A-20alpha-benzoate binding to sodium channels and sodium channel function by endocannabinoids. | 2008 | Neurochem. Int. | pmid:17888543 |
Rimmerman N et al. | Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. | 2008 | Br. J. Pharmacol. | pmid:17965731 |
Hill MN et al. | Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. | 2008 | Hippocampus | pmid:18058925 |
Maccarrone M et al. | Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. | 2008 | Nat. Neurosci. | pmid:18204441 |
Hashimotodani Y et al. | Pharmacological evidence for the involvement of diacylglycerol lipase in depolarization-induced endocanabinoid release. | 2008 | Neuropharmacology | pmid:17655882 |
Mátyás F et al. | Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. | 2008 | Neuropharmacology | pmid:17655884 |
Starowicz KM et al. | Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet. | 2008 | Obesity (Silver Spring) | pmid:18239598 |
Shimizu T and Yokotani K | Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats. | 2008 | Eur. J. Pharmacol. | pmid:18234185 |
Moreira FA et al. | Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. | 2008 | Neuropharmacology | pmid:17709120 |
Tam J et al. | The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. | 2008 | FASEB J. | pmid:17704191 |
Chiu CQ and Castillo PE | Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. | 2008 | Neuropharmacology | pmid:17706254 |
Vellani V et al. | Functional lipidomics. Calcium-independent activation of endocannabinoid/endovanilloid lipid signalling in sensory neurons by protein kinases C and A and thrombin. | 2008 | Neuropharmacology | pmid:18329052 |
Engeli S et al. | Peripheral endocannabinoid system activity in patients treated with sibutramine. | 2008 | Obesity (Silver Spring) | pmid:18356837 |
Guindon J and Hohmann AG | A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. | 2008 | Br. J. Pharmacol. | pmid:18297102 |
Oláh M et al. | The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. | 2008 | Mol. Cell. Endocrinol. | pmid:18308464 |
Hu SS et al. | Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. | 2008 | Br. J. Pharmacol. | pmid:18297109 |
Friedman SL and Nieto N | Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors. | 2008 | Cell Metab. | pmid:18316020 |
Hill MN et al. | Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. | 2008 | Pharmacopsychiatry | pmid:18311684 |
Jeong WI et al. | Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. | 2008 | Cell Metab. | pmid:18316028 |
Palkovits M et al. | Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. | 2008 | Neuroscience | pmid:18343585 |
Nomura DK et al. | Activation of the endocannabinoid system by organophosphorus nerve agents. | 2008 | Nat. Chem. Biol. | pmid:18438404 |
Bisogno T | Endogenous cannabinoids: structure and metabolism. | 2008 | J. Neuroendocrinol. | pmid:18426492 |
Rubio M et al. | CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | 2008 | Neuropharmacology | pmid:18371990 |
Di Marzo V and Maccarrone M | FAAH and anandamide: is 2-AG really the odd one out? | 2008 | Trends Pharmacol. Sci. | pmid:18394720 |
Solinas M et al. | The endocannabinoid system in brain reward processes. | 2008 | Br. J. Pharmacol. | pmid:18414385 |
Richardson D et al. | Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. | 2008 | Arthritis Res. Ther. | pmid:18416822 |
Ruby MA et al. | Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18794527 |
Ortar G et al. | Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. | 2008 | J. Med. Chem. | pmid:18831576 |
Palmer JA et al. | Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse. | 2008 | Neuroscience | pmid:18541380 |
Hoover HS et al. | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18657971 |
Marinelli S et al. | The endocannabinoid 2-arachidonoylglycerol is responsible for the slow self-inhibition in neocortical interneurons. | 2008 | J. Neurosci. | pmid:19074027 |
Lu TS et al. | Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. | 2008 | J. Immunol. | pmid:18941231 |
Di Marzo V | Endocannabinoids: synthesis and degradation. | 2008 | Rev. Physiol. Biochem. Pharmacol. | pmid:18481028 |
Pertwee RG | Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. | 2008 | Addict Biol | pmid:18482430 |
Di Filippo M et al. | Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis. | 2008 | J. Neurol. Neurosurg. Psychiatr. | pmid:18535023 |
Awumey EM et al. | Cytochrome P-450 metabolites of 2-arachidonoylglycerol play a role in Ca2+-induced relaxation of rat mesenteric arteries. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18375719 |
Hill MN et al. | Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. | 2008 | J Neural Transm | pmid:18974922 |
Ellgren M et al. | Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. | 2008 | Eur Neuropsychopharmacol | pmid:18674887 |
Fowler CJ and Ghafouri N | Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake? | 2008 | Pharmacol. Res. | pmid:18675915 |
Fowler CJ | "The tools of the trade"--an overview of the pharmacology of the endocannabinoid system. | 2008 | Curr. Pharm. Des. | pmid:18781976 |
Placzek EA et al. | Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. | 2008 | J. Neurochem. | pmid:18778304 |
Placzek EA et al. | Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. | 2008 | Neuropharmacology | pmid:18760289 |
Qin N et al. | TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008 | J. Neurosci. | pmid:18550765 |
Lehtonen M et al. | Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes. | 2008 | Chem. Biodivers. | pmid:19035572 |
Sheinin A et al. | Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. | 2008 | J. Neurophysiol. | pmid:18497350 |
Zhang J and Chen C | Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. | 2008 | J. Biol. Chem. | pmid:18534982 |
Nabemoto M et al. | Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha. | 2008 | Eur. J. Pharmacol. | pmid:18539271 |
Endsley MP et al. | Expression and function of fatty acid amide hydrolase in prostate cancer. | 2008 | Int. J. Cancer | pmid:18566995 |
Rockwell CE et al. | A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. | 2008 | Biochem. Pharmacol. | pmid:18571623 |
Njie YF et al. | Aqueous humor outflow effects of 2-arachidonylglycerol. | 2008 | Exp. Eye Res. | pmid:18597752 |
Muccioli GG and Stella N | An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. | 2008 | Anal. Biochem. | pmid:17981259 |
Motaghedi R and McGraw TE | The CB1 endocannabinoid system modulates adipocyte insulin sensitivity. | 2008 | Obesity (Silver Spring) | pmid:18551116 |
Thiemann G et al. | The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization. | 2008 | Behav. Brain Res. | pmid:17988751 |
Burston JJ et al. | N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18682568 |
Avraham Y et al. | 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18771906 |
Koppel J et al. | Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. | 2009 | Lipids Health Dis | pmid:19144193 |
Nyilas R et al. | Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. | 2009 | Eur. J. Neurosci. | pmid:19453631 |
Wakley AA and Rasmussen EB | Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. | 2009 | Pharmacol. Biochem. Behav. | pmid:19602424 |
Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
Schroeder C et al. | Circulating endocannabinoid concentrations during orthostatic stress. | 2009 | Clin. Auton. Res. | pmid:19756829 |
Thors L and Fowler CJ | Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. | 2009 | Eur. J. Pharmacol. | pmid:19715690 |