2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Griebel G et al. | Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. | 2015 | Sci Rep | pmid:25560837 |
Zhang J et al. | Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury. | 2015 | J. Cereb. Blood Flow Metab. | pmid:25492114 |
Shonesy BC et al. | The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium. | 2015 | Neuropharmacology | pmid:25484252 |
Costa MA et al. | 2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development. | 2015 | Mol. Cell. Endocrinol. | pmid:25199616 |
Pasquarelli N et al. | Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue. | 2015 | Neuropharmacology | pmid:25497453 |
Qi M et al. | A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26411510 |
Cascio MG and Marini P | Biosynthesis and Fate of Endocannabinoids. | 2015 | Handb Exp Pharmacol | pmid:26408157 |
Liu J et al. | Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. | 2015 | Neurotoxicology | pmid:26215119 |
Pacioni G et al. | Truffles contain endocannabinoid metabolic enzymes and anandamide. | 2015 | Phytochemistry | pmid:25433633 |
Imperatore R et al. | Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CBâ‚R signaling and anxiety-like behavior. | 2015 | J. Neurochem. | pmid:26223500 |
Anderson GR et al. | β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. | 2015 | Cell | pmid:26213384 |
Viader A et al. | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. | 2015 | Cell Rep | pmid:26212325 |
Straiker A et al. | Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. | 2015 | Pharmacol. Res. | pmid:26211948 |
González-Mariscal I et al. | Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. | 2016 | Mol. Cell. Endocrinol. | pmid:26724516 |
Rajaraman G et al. | G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. | 2016 | Mol Nutr Food Res | pmid:26337420 |
Aso C et al. | Protein purification and cloning of diacylglycerol lipase from rat brain. | 2016 | J. Biochem. | pmid:26790472 |
Buczynski MW et al. | Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26755579 |
Imperatore R et al. | Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. | 2016 | Pharmacol. Res. | pmid:27436148 |
Janssen FJ and van der Stelt M | Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. | 2016 | Bioorg. Med. Chem. Lett. | pmid:27394666 |
Mwanza C et al. | Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27318292 |