2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Limebeer CL et al. | Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. | 2016 | Behav. Neurosci. | pmid:26974857 |
Feliszek M et al. | Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. | 2016 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26984820 |
Zhang L et al. | Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. | 2016 | Neuroscience | pmid:26924019 |
Tomas-Roig J et al. | Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. | 2016 | Behav. Brain Res. | pmid:26815100 |
Siegmund SV et al. | Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26801558 |
Yi B et al. | Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors. | 2016 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:26780604 |
Costa MA et al. | The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast. | 2016 | Biochim. Biophys. Acta | pmid:26698196 |
Sanchez AM et al. | Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. | 2016 | Reprod Sci | pmid:26887427 |
Jenniches I and Zimmer A | Reply to: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. | 2016 | Biol. Psychiatry | pmid:26410564 |
Patel S et al. | The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. | 2016 | Biol. Psychiatry | pmid:26212898 |
Doenni VM et al. | Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. | 2016 | Brain Behav. Immun. | pmid:27453335 |
Dong L et al. | Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. | 2016 | J. Lipid Res. | pmid:27059979 |
Schlabritz-Loutsevitch N et al. | Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. | 2016 | Med. Hypotheses | pmid:27959272 |
Iannotti FA et al. | Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. | 2016 | Prog. Lipid Res. | pmid:26965148 |
Gamelin FX et al. | Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. | 2016 | J. Physiol. Biochem. | pmid:26880264 |
Monteleone AM et al. | Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. | 2016 | Eur J Nutr | pmid:26759262 |
Malek N et al. | The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. | 2016 | Pharmacol. Res. | pmid:27326920 |
Sharkey KA and Wiley JW | The Role of the Endocannabinoid System in the Brain-Gut Axis. | 2016 | Gastroenterology | pmid:27133395 |
Sido JM et al. | Production of endocannabinoids by activated TÂ cells and BÂ cells modulates inflammation associated with delayed-type hypersensitivity. | 2016 | Eur. J. Immunol. | pmid:27064137 |
Brose SA et al. | Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. | 2016 | Lipids | pmid:27021494 |
Delgado-Peraza F et al. | Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. | 2016 | Mol. Pharmacol. | pmid:27009233 |
Miller MR et al. | Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. | 2016 | Science | pmid:26989199 |
McReynolds JR et al. | CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. | 2016 | Psychopharmacology (Berl.) | pmid:26455361 |
Lim J et al. | Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. | 2016 | Neuropsychopharmacology | pmid:26361059 |
Stark DT and Caprioli J | Subcellular Localization of a 2-Arachidonoyl Glycerol Signaling Cassette in Retinal Ganglion Cell Axonal Growth In Vitro. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:28002563 |
Wang X et al. | Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat. | 2016 | Epilepsy Res. | pmid:27810514 |
Wiley JL et al. | Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. | 2016 | Behav Pharmacol | pmid:27385208 |
Chen Y et al. | Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. | 2016 May-Jun | eNeuro | pmid:27182552 |
Pascual AC et al. | 2-Arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals. | 2017 | Neuroscience | pmid:28844762 |
Xu C et al. | Endocannabinoids exert CB receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein. | 2017 | Mol. Cell. Neurosci. | pmid:28733129 |
Summers T et al. | Endocannabinoids Have Opposing Effects On Behavioral Responses To Nociceptive And Non-nociceptive Stimuli. | 2017 | Sci Rep | pmid:28724917 |
Francou MM et al. | Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid. | 2017 | Histol. Histopathol. | pmid:28585678 |
Chicca A et al. | Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28584105 |
Becker TM et al. | Endocannabinoid-dependent disinhibition of orexinergic neurons: Electrophysiological evidence in leptin-knockout obese mice. | 2017 | Mol Metab | pmid:28580289 |
Fanelli F et al. | Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women. | 2017 | Mol Metab | pmid:28462075 |
Bedse G et al. | Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety. | 2017 | Biol. Psychiatry | pmid:28438413 |
Pasquarelli N et al. | Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS. | 2017 | Neuropharmacology | pmid:28373073 |
Bluett RJ et al. | Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. | 2017 | Nat Commun | pmid:28348378 |
Kranaster L et al. | Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study. | 2017 | Eur Arch Psychiatry Clin Neurosci | pmid:28342110 |
Dotsey E et al. | Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice. | 2017 | Sci Rep | pmid:28209996 |
Pei R et al. | Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial. | 2017 | Br. J. Nutr. | pmid:29179781 |
Kondakala S et al. | Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29097212 |
Forner-Piquer I et al. | Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. | 2017 | Endocrinology | pmid:28938452 |
Martin GG et al. | Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant. | 2017 | Biochemistry | pmid:28853554 |
Karwad MA et al. | The role of CB in intestinal permeability and inflammation. | 2017 | FASEB J. | pmid:28404744 |
Saravia R et al. | CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. | 2017 | Biol. Psychiatry | pmid:27737762 |
Granchi C et al. | A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017). | 2017 | Expert Opin Ther Pat | pmid:29053063 |
Leonard MZ et al. | Cannabinoid CB Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors. | 2017 | J. Pharmacol. Exp. Ther. | pmid:28947487 |
Feliú A et al. | 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination. | 2017 | J. Neurosci. | pmid:28751457 |
Abed SM et al. | Synthesis of 1,3-dioleoyl-2-arachidonoylglycerol-rich structured lipids by lipase-catalyzed acidolysis of microbial oil from Mortierella alpina. | 2017 | Bioresour. Technol. | pmid:28688328 |