2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fuss J et al. | Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans. | 2017 | J Sex Med | pmid:29110806 |
Valastro C et al. | Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study. | 2017 | BMC Vet. Res. | pmid:29110674 |
Artegoitia VM et al. | Endocannabinoid concentrations in plasma during the finishing period are associated with feed efficiency and carcass composition of beef cattle. | 2017 | J. Anim. Sci. | pmid:29108057 |
Wang SL et al. | [Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells]. | 2017 | Sheng Li Xue Bao | pmid:29063116 |
Poursharifi P et al. | Monoacylglycerol signalling and ABHD6 in health and disease. | 2017 | Diabetes Obes Metab | pmid:28880480 |
Raff H et al. | Increase in the circulating endocannabinoid 2-arachidonoylglycerol is associated with gabapentin use in septic ICU patients. | 2017 | Endocrine | pmid:28875451 |
Avraham Y et al. | 2-Arachidonoylglycerol as a possible treatment for anorexia nervosa in animal model in mice. | 2017 | Brain Res. | pmid:28606779 |
Vujic N et al. | Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. | 2017 | Oncotarget | pmid:28380440 |
Brellenthin AG et al. | Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. | 2017 | Med Sci Sports Exerc | pmid:28319590 |
Pei R et al. | Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial. | 2017 | Br. J. Nutr. | pmid:29179781 |
Kondakala S et al. | Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice. | 2017 | Toxicol. Appl. Pharmacol. | pmid:29097212 |
Forner-Piquer I et al. | Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. | 2017 | Endocrinology | pmid:28938452 |
Almeida-Santos AF et al. | 2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex. | 2017 | J. Psychopharmacol. (Oxford) | pmid:28440729 |
Martin GG et al. | Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant. | 2017 | Biochemistry | pmid:28853554 |
Soni N et al. | Anandamide and 2-AG are endogenously present within the laterodorsal tegmental nucleus: Functional implications for a role of eCBs in arousal. | 2017 | Brain Res. | pmid:28404451 |
Marchioni C et al. | A column switching ultrahigh-performance liquid chromatography-tandem mass spectrometry method to determine anandamide and 2-arachidonoylglycerol in plasma samples. | 2017 | Anal Bioanal Chem | pmid:28337517 |
Karwad MA et al. | The role of CB in intestinal permeability and inflammation. | 2017 | FASEB J. | pmid:28404744 |
Cui N et al. | Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin. | 2017 | Clin Ther | pmid:28291580 |
Saravia R et al. | CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. | 2017 | Biol. Psychiatry | pmid:27737762 |
Gantz SC and Bean BP | Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling. | 2017 | Neuron | pmid:28262417 |
Granchi C et al. | A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017). | 2017 | Expert Opin Ther Pat | pmid:29053063 |
Leonard MZ et al. | Cannabinoid CB Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors. | 2017 | J. Pharmacol. Exp. Ther. | pmid:28947487 |
Feliú A et al. | 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination. | 2017 | J. Neurosci. | pmid:28751457 |
Abed SM et al. | Synthesis of 1,3-dioleoyl-2-arachidonoylglycerol-rich structured lipids by lipase-catalyzed acidolysis of microbial oil from Mortierella alpina. | 2017 | Bioresour. Technol. | pmid:28688328 |
Karpińska O et al. | Activation of CB receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. | 2017 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:28356298 |
Chanda D et al. | 2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes. | 2017 | J. Biol. Chem. | pmid:28320859 |
Bakas T et al. | The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA receptors. | 2017 | Pharmacol. Res. | pmid:28249817 |
Haruna T et al. | The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice. | 2017 | Pharmacology | pmid:28214870 |
Pagano E et al. | Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis. | 2017 | Pharmacol. Res. | pmid:28193521 |
Smaga I et al. | Changes in the Brain Endocannabinoid System in Rat Models of Depression. | 2017 | Neurotox Res | pmid:28247204 |
Quartu M et al. | Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. | 2017 | Lipids Health Dis | pmid:28103941 |
Biernacki M et al. | Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. | 2018 | Prostaglandins Other Lipid Mediat. | pmid:30201316 |
DeVuono MV et al. | Conditioned gaping produced by high dose Δ-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system. | 2018 | Neuropharmacology | pmid:30195587 |
Covey DP et al. | Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease. | 2018 | Neuropsychopharmacology | pmid:29925886 |
Ratano P et al. | Pharmacological inhibition of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation. | 2018 | Neuropharmacology | pmid:29842858 |
Jehle J et al. | Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. | 2018 | PLoS ONE | pmid:29813086 |
Forner-Piquer I et al. | Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. | 2018 | Environ. Pollut. | pmid:29793103 |
Baggelaar MP et al. | 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain. | 2018 | Prog. Lipid Res. | pmid:29751000 |
Coccaro EF et al. | Circulating endocannabinoids and affect regulation in human subjects. | 2018 | Psychoneuroendocrinology | pmid:29627714 |
Nagappan A et al. | Protective Effects of Gomisin N against Hepatic Cannabinoid Type 1 Receptor-Induced Insulin Resistance and Gluconeogenesis. | 2018 | Int J Mol Sci | pmid:29570673 |
Wang Y et al. | Identification of metabolite biomarkers for L-DOPA-induced dyskinesia in a rat model of Parkinson's disease by metabolomic technology. | 2018 | Behav. Brain Res. | pmid:29551735 |
Wu SY et al. | Metabolomic assessment of arsenite toxicity and novel biomarker discovery in early development of zebrafish embryos. | 2018 | Toxicol. Lett. | pmid:29551592 |
Wingenfeld K et al. | Reduced levels of the endocannabinoid arachidonylethanolamide (AEA) in hair in patients with borderline personality disorder - a pilot study. | 2018 | Stress | pmid:29546791 |
Haj-Dahmane S et al. | Fatty-acid-binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29531087 |
Atsak P et al. | Glucocorticoid-endocannabinoid uncoupling mediates fear suppression deficits after early - Life stress. | 2018 | Psychoneuroendocrinology | pmid:29524763 |
Zareie P et al. | Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures. | 2018 | Metab Brain Dis | pmid:29504066 |
Kamimura R et al. | Inhibition of 2-arachydonoylgycerol degradation attenuates orofacial neuropathic pain in trigeminal nerve-injured mice. | 2018 | J Oral Sci | pmid:29503395 |
Signorello MG and Leoncini G | Activation of CaMKKβ/AMPKα pathway by 2-AG in human platelets. | 2018 | J. Cell. Biochem. | pmid:28661046 |
Szafran BN et al. | Characterization of Endocannabinoid-Metabolizing Enzymes in Human Peripheral Blood Mononuclear Cells under Inflammatory Conditions. | 2018 | Molecules | pmid:30513753 |
Iannotti FA et al. | Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy. | 2018 | Nat Commun | pmid:30262909 |