2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang J and Ueda N | Biology of endocannabinoid synthesis system. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19126434 |
Vignali M et al. | The endocannabinoid anandamide inhibits potassium conductance in rat cortical astrocytes. | 2009 | Glia | pmid:19031444 |
Dowie MJ et al. | Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. | 2009 | Neuroscience | pmid:19524019 |
Maeda N et al. | Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. | 2009 | Fundam Clin Pharmacol | pmid:19527302 |
Straiker A and Mackie K | Cannabinoid signaling in inhibitory autaptic hippocampal neurons. | 2009 | Neuroscience | pmid:19501632 |
Kinsey SG et al. | Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19502530 |
Guasti L et al. | Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. | 2009 | Mol Pain | pmid:19570201 |
Grimaldi P et al. | The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19541620 |
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Yates ML and Barker EL | Inactivation and biotransformation of the endogenous cannabinoids anandamide and 2-arachidonoylglycerol. | 2009 | Mol. Pharmacol. | pmid:19389920 |
Hill MN et al. | Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. | 2009 | Psychoneuroendocrinology | pmid:19394765 |
Guindon J and Hohmann AG | The endocannabinoid system and pain. | 2009 | CNS Neurol Disord Drug Targets | pmid:19839937 |
Marco EM and Viveros MP | The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. | 2009 | Mini Rev Med Chem | pmid:19929814 |
Alvarez-Jaimes L et al. | Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats. | 2009 | J. Neurochem. | pmid:19650871 |
Kreutz S et al. | 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. | 2009 | Glia | pmid:18837048 |
Di Marzo V et al. | Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors. | 2009 | Diabetologia | pmid:18972095 |
Avraham Y et al. | Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice. | 2009 | Br. J. Pharmacol. | pmid:19764982 |
Urbanski MJ et al. | Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. | 2009 | Synapse | pmid:19347961 |
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Bajo M et al. | Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands. | 2009 | J. Neurosci. Res. | pmid:18816788 |
Bisogno T et al. | Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. | 2009 | Biochim. Biophys. Acta | pmid:19027877 |
Long JZ et al. | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. | 2009 | Nat. Chem. Biol. | pmid:19029917 |
Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
Schlosburg JE et al. | Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation. | 2009 | AAPS J | pmid:19184452 |
Koppel J et al. | Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. | 2009 | Lipids Health Dis | pmid:19144193 |
Nyilas R et al. | Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. | 2009 | Eur. J. Neurosci. | pmid:19453631 |
Garcia-Ovejero D et al. | The endocannabinoid system is modulated in response to spinal cord injury in rats. | 2009 | Neurobiol. Dis. | pmid:18930143 |
Wakley AA and Rasmussen EB | Effects of cannabinoid drugs on the reinforcing properties of food in gestationally undernourished rats. | 2009 | Pharmacol. Biochem. Behav. | pmid:19602424 |
Prusakiewicz JJ et al. | Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid. | 2009 | Biochemistry | pmid:19603831 |
Long JZ et al. | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19918051 |
Bowman AL and Makriyannis A | Refined homology model of monoacylglycerol lipase: toward a selective inhibitor. | 2009 | J. Comput. Aided Mol. Des. | pmid:19543978 |
Long JZ et al. | Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. | 2009 | Chem. Biol. | pmid:19635411 |
Patel S et al. | Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. | 2009 | Neuropsychopharmacology | pmid:19675536 |
Pan B et al. | Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19666749 |
Li Q and Burrell BD | Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent. | 2009 | J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. | pmid:19657662 |
Morgan NH et al. | Functional CB2 type cannabinoid receptors at CNS synapses. | 2009 | Neuropharmacology | pmid:19616018 |
Izzo AA et al. | Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding. | 2009 | Br. J. Pharmacol. | pmid:19371345 |
Bermúdez-Silva FJ et al. | The role of the pancreatic endocannabinoid system in glucose metabolism. | 2009 | Best Pract. Res. Clin. Endocrinol. Metab. | pmid:19285263 |
Schroeder C et al. | Circulating endocannabinoid concentrations during orthostatic stress. | 2009 | Clin. Auton. Res. | pmid:19756829 |
Catani MV et al. | Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol. | 2009 | J. Mol. Med. | pmid:18820887 |
Thors L and Fowler CJ | Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. | 2009 | Eur. J. Pharmacol. | pmid:19715690 |
Maison P et al. | BDNF regulates neuronal sensitivity to endocannabinoids. | 2009 | Neurosci. Lett. | pmid:19818836 |
Di Marzo V et al. | Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects. | 2009 | Eur. J. Endocrinol. | pmid:19745037 |
Gkini E et al. | Metabolism of 2-acylglycerol in rabbit and human platelets. Involvement of monoacylglycerol lipase and fatty acid amide hydrolase. | 2009 | Platelets | pmid:19811221 |
Jiang LS et al. | Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages. | 2009 | Cardiovasc. Res. | pmid:19074161 |
Sugiura T | Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. | 2009 Jan-Feb | Biofactors | pmid:19319851 |
Fonseca BM et al. | The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: a role in uterine remodelling. | 2010 | Int. J. Biochem. Cell Biol. | pmid:20727980 |
Suárez J et al. | Endocannabinoid system in the adult rat circumventricular areas: an immunohistochemical study. | 2010 | J. Comp. Neurol. | pmid:20533360 |
Telleria-Diaz A et al. | Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. | 2010 | Pain | pmid:19879047 |