2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hutchins-Wiese HL et al. | Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. | 2012 | J. Nutr. Biochem. | pmid:22051448 |
Haas MJ et al. | Inhibition of apolipoprotein A-I gene expression by obesity-associated endocannabinoids. | 2012 | Obesity (Silver Spring) | pmid:22016100 |
Heyman E et al. | Intense exercise increases circulating endocannabinoid and BDNF levels in humans--possible implications for reward and depression. | 2012 | Psychoneuroendocrinology | pmid:22029953 |
Chang JW et al. | Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. | 2012 | Chem. Biol. | pmid:22542104 |
Forsell PK et al. | Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. | 2012 | Lipids | pmid:22684912 |
Atwood BK et al. | CBâ‚‚ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons. | 2012 | Neuropharmacology | pmid:22579668 |
Spivak CE et al. | Blockade of β-cell K(ATP) channels by the endocannabinoid, 2-arachidonoylglycerol. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22609205 |
Straiker A et al. | Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones. | 2012 | Br. J. Pharmacol. | pmid:22014238 |
Atsak P et al. | Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22331883 |
Chon SH et al. | Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. | 2012 | PLoS ONE | pmid:22937137 |
Musee J and Marnett LJ | Prostaglandin H synthase-2-catalyzed oxygenation of 2-arachidonoylglycerol is more sensitive to peroxide tone than oxygenation of arachidonic acid. | 2012 | J. Biol. Chem. | pmid:22942274 |
Wang DJ et al. | Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. | 2012 | PLoS ONE | pmid:22927908 |
Fanelli F et al. | Estimation of reference intervals of five endocannabinoids and endocannabinoid related compounds in human plasma by two dimensional-LC/MS/MS. | 2012 | J. Lipid Res. | pmid:22172516 |
Roberts CJ et al. | Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. | 2012 | Neuroscience | pmid:22192839 |
Thomas KC et al. | Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21949157 |
Woodhams SG et al. | Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. | 2012 | Br. J. Pharmacol. | pmid:22924700 |
Schulte K et al. | Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. | 2012 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:22215206 |
Gatta-Cherifi B et al. | Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity. | 2012 | Int J Obes (Lond) | pmid:21844878 |
Oleson EB et al. | Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum. | 2012 | Neuron | pmid:22284189 |
Xu JY et al. | Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids. | 2012 | J. Physiol. (Lond.) | pmid:22411015 |
Echigo R et al. | Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells. | 2012 | Oncol. Rep. | pmid:22842590 |
Kortleven C et al. | Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG. | 2012 | Neuropharmacology | pmid:22884466 |
Petrovszki Z et al. | The effects of peptide and lipid endocannabinoids on arthritic pain at the spinal level. | 2012 | Anesth. Analg. | pmid:22451592 |
Tanimura A et al. | Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22783023 |
Caprioli A et al. | The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22514334 |
Monteleone P et al. | Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22442280 |
Ritter JK et al. | Production and actions of the anandamide metabolite prostamide E2 in the renal medulla. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22685343 |
Chicca A et al. | The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. | 2012 | Br. J. Pharmacol. | pmid:22646533 |
Tsumura M et al. | TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. | 2012 | Cell Calcium | pmid:22656960 |
Kallendrusch S et al. | Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage. | 2012 | PLoS ONE | pmid:23284665 |
Tanveer R et al. | The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats. | 2012 | J. Biol. Chem. | pmid:22891244 |
Chicca A et al. | Evidence for bidirectional endocannabinoid transport across cell membranes. | 2012 | J. Biol. Chem. | pmid:22879589 |
Melis M and Pistis M | Hub and switches: endocannabinoid signalling in midbrain dopamine neurons. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108546 |
Chanda D et al. | Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. | 2012 | J. Biol. Chem. | pmid:22989885 |
Strewe C et al. | Effects of parabolic flight and spaceflight on the endocannabinoid system in humans. | 2012 | Rev Neurosci | pmid:23023882 |
Whyte LS et al. | Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. | 2012 | Br. J. Pharmacol. | pmid:21649637 |
Skaper SD and Di Marzo V | Endocannabinoids in nervous system health and disease: the big picture in a nutshell. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108539 |
Booker L et al. | The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. | 2012 | Br. J. Pharmacol. | pmid:21506952 |
Di Marzo V and De Petrocellis L | Why do cannabinoid receptors have more than one endogenous ligand? | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108541 |
Puighermanal E et al. | Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108544 |
Starowicz K and Przewlocka B | Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108547 |
Rani Sagar D et al. | Dynamic changes to the endocannabinoid system in models of chronic pain. | 2012 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:23108548 |
Sticht MA et al. | Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats. | 2012 | Br. J. Pharmacol. | pmid:21470205 |
Jung KM et al. | Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. | 2012 | Nat Commun | pmid:23011134 |
Gyombolai P et al. | Regulation of endocannabinoid release by G proteins: a paracrine mechanism of G protein-coupled receptor action. | 2012 | Mol. Cell. Endocrinol. | pmid:22075205 |
Navia-Paldanius D et al. | Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). | 2012 | J. Lipid Res. | pmid:22969151 |
Zoerner AA et al. | Simultaneous UPLC-MS/MS quantification of the endocannabinoids 2-arachidonoyl glycerol (2AG), 1-arachidonoyl glycerol (1AG), and anandamide in human plasma: minimization of matrix-effects, 2AG/1AG isomerization and degradation by toluene solvent extraction. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21752730 |
Raman P et al. | 15-Deoxy-Δ¹²,¹â´-prostaglandin Jâ‚‚-glycerol, a putative metabolite of 2-arachidonyl glycerol and a peroxisome proliferator-activated receptor γ ligand, modulates nuclear factor of activated T cells. | 2012 | J. Pharmacol. Exp. Ther. | pmid:22700433 |
Katona I and Freund TF | Multiple functions of endocannabinoid signaling in the brain. | 2012 | Annu. Rev. Neurosci. | pmid:22524785 |
Gould GG et al. | Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. | 2012 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:22542870 |