2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2-arachidonoylglycerol?

2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Per page 10 20 50 100 | Total 51

PubChem Associated disorders and diseases

What pathways are associated with 2-arachidonoylglycerol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 2-arachidonoylglycerol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2-arachidonoylglycerol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 2-arachidonoylglycerol?

Knock-out

Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with 2-arachidonoylglycerol

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Authors Title Published Journal PubMed Link
Artegoitia VM et al. Endocannabinoids concentrations in plasma associated with feed efficiency and carcass composition of beef steers. 2016 J. Anim. Sci. pmid:28046144
Thompson Z et al. Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes. 2017 Physiol. Behav. pmid:28017680
Stark DT and Caprioli J Subcellular Localization of a 2-Arachidonoyl Glycerol Signaling Cassette in Retinal Ganglion Cell Axonal Growth In Vitro. 2016 Invest. Ophthalmol. Vis. Sci. pmid:28002563
Kantae V et al. Quantitative profiling of endocannabinoids and related -acylethanolamines in human CSF using nano LC-MS/MS. 2017 J. Lipid Res. pmid:27999147
Schlabritz-Loutsevitch N et al. Fetal Syndrome of Endocannabinoid Deficiency (FSECD) In Maternal Obesity. 2016 Med. Hypotheses pmid:27959272
Knani I et al. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. 2016 Mol Metab pmid:27900261
Wilkerson JL et al. The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice. 2017 Neuropharmacology pmid:27890602
Hassanzadeh P et al. Application of carbon nanotubes as the carriers of the cannabinoid, 2-arachidonoylglycerol: Towards a novel treatment strategy in colitis. 2017 Life Sci. pmid:27888115
Barbonetti A et al. 2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages. 2017 Andrology pmid:27863106
Zelber-Sagi S et al. Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease. 2017 Obesity (Silver Spring) pmid:27863097
Wang X et al. Endogenous cannabinoid system alterations and their role in epileptogenesis after brain injury in rat. 2016 Epilepsy Res. pmid:27810514
Matthews AT et al. Oxyradical stress increases the biosynthesis of 2-arachidonoylglycerol: involvement of NADPH oxidase. 2016 Am. J. Physiol., Cell Physiol. pmid:27784678
Fisette A et al. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. 2016 Cell Rep pmid:27783937
Liu X et al. Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase. 2016 Sci Rep pmid:27775008
Saravia R et al. CB Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal. 2017 Biol. Psychiatry pmid:27737762
Morena M et al. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. 2016 Neuropharmacology pmid:27553121
Di S et al. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. 2016 J. Neurosci. pmid:27511017
Doenni VM et al. Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. 2016 Brain Behav. Immun. pmid:27453335
Sugaya Y et al. Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures. 2016 Cell Rep pmid:27452464
Bosch-Bouju C et al. Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress. 2016 Cell Rep pmid:27452462
Aaltonen N et al. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). 2016 J. Pharmacol. Exp. Ther. pmid:27451409
Veeraraghavan P et al. A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. 2016 Neuroscience pmid:27450568
Tung LW et al. Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. 2016 Nat Commun pmid:27448020
Imperatore R et al. Formation of OX-1R/CB1R heteromeric complexes in embryonic mouse hypothalamic cells: Effect on intracellular calcium, 2-arachidonoyl-glycerol biosynthesis and ERK phosphorylation. 2016 Pharmacol. Res. pmid:27436148
Janssen FJ and van der Stelt M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. 2016 Bioorg. Med. Chem. Lett. pmid:27394666
Wiley JL et al. Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice. 2016 Behav Pharmacol pmid:27385208
Malek N et al. The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain. 2016 Pharmacol. Res. pmid:27326920
Mwanza C et al. Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:27318292
van Zadelhoff G and van der Stelt M Oxygenation of Anandamide by Lipoxygenases. 2016 Methods Mol. Biol. pmid:27245907
Kudalkar SN et al. Assay of Endocannabinoid Oxidation by Cyclooxygenase-2. 2016 Methods Mol. Biol. pmid:27245906
Jung KM and Piomelli D Assay of Monoacylglycerol Lipase Activity. 2016 Methods Mol. Biol. pmid:27245902
Bisogno T Assay of DAGLα/β Activity. 2016 Methods Mol. Biol. pmid:27245901
Battista N and Sergi M Determination of 2-Arachidonoylglycerol by μSPE-LC-MS/MS. 2016 Methods Mol. Biol. pmid:27245888
Araki M et al. Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. 2016 J. Biochem. pmid:27198176
Reddy IA et al. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. 2016 Transl Psychiatry pmid:27187231
Chen Y et al. Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. 2016 May-Jun eNeuro pmid:27182552
Liisberg U et al. Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice. 2016 J. Nutr. Biochem. pmid:27155918
Sharkey KA and Wiley JW The Role of the Endocannabinoid System in the Brain-Gut Axis. 2016 Gastroenterology pmid:27133395
Zou Z et al. Endocannabinoid 2-Arachidonoylglycerol Suppresses LPS-Induced Inhibition of A-Type Potassium Channel Currents in Caudate Nucleus Neurons Through CB1 Receptor. 2016 J. Mol. Neurosci. pmid:27129498
Leishman E et al. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. 2016 Pharmacol. Res. pmid:27109320
Sido JM et al. Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed-type hypersensitivity. 2016 Eur. J. Immunol. pmid:27064137
Dong L et al. Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2. 2016 J. Lipid Res. pmid:27059979
Brose SA et al. Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. 2016 Lipids pmid:27021494
Martella A et al. Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop. 2016 Endocrinology pmid:27014939
Delgado-Peraza F et al. Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor. 2016 Mol. Pharmacol. pmid:27009233
Keyshams N et al. Cannabinoid-glutamate interactions in the regulation of food intake in neonatal layer- type chicks: role of glutamate NMDA and AMPA receptors. 2016 Vet. Res. Commun. pmid:27000110
Miller MR et al. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. 2016 Science pmid:26989199
Feliszek M et al. Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. 2016 Naunyn Schmiedebergs Arch. Pharmacol. pmid:26984820
Limebeer CL et al. Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model. 2016 Behav. Neurosci. pmid:26974857
Iannotti FA et al. Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders. 2016 Prog. Lipid Res. pmid:26965148
Leishman E et al. Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain. 2016 Biochim. Biophys. Acta pmid:26956082
Yan W et al. NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication. 2016 Sci Rep pmid:26928013
Hartley ND et al. 2-arachidonoylglycerol signaling impairs short-term fear extinction. 2016 Transl Psychiatry pmid:26926885
Zhang L et al. Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. 2016 Neuroscience pmid:26924019
Wang X et al. Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. 2016 Biomed Res Int pmid:26904688
Brindisi M et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. 2016 J. Med. Chem. pmid:26888301
Sanchez AM et al. Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis. 2016 Reprod Sci pmid:26887427
Gamelin FX et al. Effects of chronic exercise on the endocannabinoid system in Wistar rats with high-fat diet-induced obesity. 2016 J. Physiol. Biochem. pmid:26880264
Tegeder I Endocannabinoids as Guardians of Metastasis. 2016 Int J Mol Sci pmid:26875980
Pastor A et al. A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. 2016 PLoS ONE pmid:26849214
Gray JM et al. Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. 2016 Psychoneuroendocrinology pmid:26821211
Tomas-Roig J et al. Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. 2016 Behav. Brain Res. pmid:26815100
Siegmund SV et al. Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. 2016 Biochem. Biophys. Res. Commun. pmid:26801558
Wilkerson JL et al. The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. 2016 J. Pharmacol. Exp. Ther. pmid:26791602
Aso C et al. Protein purification and cloning of diacylglycerol lipase from rat brain. 2016 J. Biochem. pmid:26790472
Yi B et al. Reductions in circulating endocannabinoid 2-arachidonoylglycerol levels in healthy human subjects exposed to chronic stressors. 2016 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:26780604
Monteleone AM et al. Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity. 2016 Eur J Nutr pmid:26759262
Buczynski MW et al. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26755579
González-Mariscal I et al. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice. 2016 Mol. Cell. Endocrinol. pmid:26724516
Costa MA et al. The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast. 2016 Biochim. Biophys. Acta pmid:26698196
Lu HC and Mackie K An Introduction to the Endogenous Cannabinoid System. 2016 Biol. Psychiatry pmid:26698193
Ogasawara D et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. 2016 Proc. Natl. Acad. Sci. U.S.A. pmid:26668358
Wills KL et al. Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats. 2016 Neuropsychopharmacology pmid:26647976
Carr RL et al. Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development. 2017 Neurotoxicology pmid:26642910
Gobira PH et al. Role of the endocannabinoid 2-arachidonoylglycerol in aversive responses mediated by the dorsolateral periaqueductal grey. 2016 Eur Neuropsychopharmacol pmid:26628106
Yang W et al. Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells. 2016 Neuroscience pmid:26621126
Hanlon EC et al. Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. 2016 Sleep pmid:26612385
Vujic N et al. Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice. 2016 Atherosclerosis pmid:26584135
Mann A et al. Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? 2016 J Basic Clin Physiol Pharmacol pmid:26565551
Grabner GF et al. Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. 2016 J. Biol. Chem. pmid:26565024
Martins CJ et al. Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture. 2015 PLoS ONE pmid:26561012
Sticht MA et al. Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex. 2016 Neuropharmacology pmid:26541329
Checa A et al. Lipid mediator profile in vernix caseosa reflects skin barrier development. 2015 Sci Rep pmid:26521946
Jalin AM et al. Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. 2015 PLoS ONE pmid:26517721
Sustkova-Fiserova M et al. Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. 2016 Psychopharmacology (Berl.) pmid:26507196
Morena M et al. Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats. 2015 J. Neurosci. pmid:26468197
Signorello MG and Leoncini G Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol. 2016 J. Cell. Biochem. pmid:26460717
McReynolds JR et al. CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. 2016 Psychopharmacology (Berl.) pmid:26455361
Smith M et al. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. 2015 PLoS ONE pmid:26414859
Wang F et al. 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation. 2016 Rejuvenation Res pmid:26414218
Qi M et al. A robust capillary liquid chromatography/tandem mass spectrometry method for quantitation of neuromodulatory endocannabinoids. 2015 Rapid Commun. Mass Spectrom. pmid:26411510
Jenniches I and Zimmer A Reply to: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models. 2016 Biol. Psychiatry pmid:26410564
Cascio MG and Marini P Biosynthesis and Fate of Endocannabinoids. 2015 Handb Exp Pharmacol pmid:26408157
Zheng G et al. Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways. 2015 Exp. Neurol. pmid:26408049
Szafran B et al. Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. 2015 Prostaglandins Other Lipid Mediat. pmid:26403860
Mitchener MM et al. Competition and allostery govern substrate selectivity of cyclooxygenase-2. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26392530
Wang H et al. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. 2015 Cell Rep pmid:26365195
Lim J et al. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. 2016 Neuropsychopharmacology pmid:26361059
Rajaraman G et al. G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction. 2016 Mol Nutr Food Res pmid:26337420
Petrenko AB et al. Genetic inactivation and prolonged pharmacologic inhibition of monoacylglycerol lipase have opposite effects on anesthetic sensitivity to propofol. 2015 Eur. J. Pharmacol. pmid:26318148