| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
2-arachidonoylglycerol
2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 2-arachidonoylglycerol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 2-arachidonoylglycerol?
2-arachidonoylglycerol is suspected in Atherosclerosis, Heart Diseases, Sweet's Syndrome, Colitis, Dehydration, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 2-arachidonoylglycerol
PubChem Associated disorders and diseases
What pathways are associated with 2-arachidonoylglycerol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 2-arachidonoylglycerol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 2-arachidonoylglycerol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 2-arachidonoylglycerol?
Knock-out
Knock-out are used in the study 'Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.' (Walentiny DM et al., 2015), Knock-out are used in the study 'Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).' (Navia-Paldanius D et al., 2012) and Knock-out are used in the study 'Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.' (Viader A et al., 2015).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 2-arachidonoylglycerol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Covey DP et al. | Inhibition of endocannabinoid degradation rectifies motivational and dopaminergic deficits in the Q175 mouse model of Huntington's disease. | 2018 | Neuropsychopharmacology | pmid:29925886 |
| Wills KL et al. | Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats. | 2016 | Neuropsychopharmacology | pmid:26647976 |
| Viganò D et al. | Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain. | 2003 | Neuropsychopharmacology | pmid:12637958 |
| Morena M et al. | Enhancing Endocannabinoid Neurotransmission Augments The Efficacy of Extinction Training and Ameliorates Traumatic Stress-Induced Behavioral Alterations in Rats. | 2018 | Neuropsychopharmacology | pmid:29265107 |
| Sumislawski JJ et al. | Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. | 2011 | Neuropsychopharmacology | pmid:21849983 |
| Dubreucq S et al. | Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | 2012 | Neuropsychopharmacology | pmid:22434220 |
| Sarchielli P et al. | Endocannabinoids in chronic migraine: CSF findings suggest a system failure. | 2007 | Neuropsychopharmacology | pmid:17119542 |
| Blasio A et al. | Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. | 2013 | Neuropsychopharmacology | pmid:23793355 |
| Patel S et al. | Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. | 2009 | Neuropsychopharmacology | pmid:19675536 |
| Maccarrone M et al. | Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. | 2010 | Neuropsychopharmacology | pmid:20393458 |
| Lim J et al. | Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. | 2016 | Neuropsychopharmacology | pmid:26361059 |
| Pérez-Morales M et al. | 2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation. | 2014 | Neuroreport | pmid:25356522 |
| Beltramo M and Piomelli D | Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. | 2000 | Neuroreport | pmid:10817598 |
| Rubio M et al. | Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. | 2007 | Neurosci. Lett. | pmid:17574742 |
| Sinor AD et al. | Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats. | 2000 | Neurosci. Lett. | pmid:10653017 |
| Sugiura T et al. | Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation. | 2001 | Neurosci. Lett. | pmid:11137756 |
| Maison P et al. | BDNF regulates neuronal sensitivity to endocannabinoids. | 2009 | Neurosci. Lett. | pmid:19818836 |
| Roberts CJ et al. | Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. | 2012 | Neuroscience | pmid:22192839 |
| Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
| Palkovits M et al. | Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. | 2008 | Neuroscience | pmid:18343585 |