| MeSH term | MeSH ID | Detail |
|---|---|---|
| Aging, Premature | D019588 | 1 associated lipids |
| Hearing Loss, High-Frequency | D006316 | 1 associated lipids |
| Night Blindness | D009755 | 1 associated lipids |
| Stomatitis, Aphthous | D013281 | 1 associated lipids |
| Conjunctivitis, Allergic | D003233 | 1 associated lipids |
| Otorhinolaryngologic Neoplasms | D010039 | 2 associated lipids |
| Spinal Cord Ischemia | D020760 | 2 associated lipids |
| Torsades de Pointes | D016171 | 2 associated lipids |
| Sebaceous Gland Neoplasms | D012626 | 2 associated lipids |
| Mental Fatigue | D005222 | 3 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mottram AR et al. | Fatty acids antagonize bupivacaine-induced I(Na) blockade. | 2011 | Clin Toxicol (Phila) | pmid:21970771 |
| Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
| Zhang Y et al. | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21592363 |
| He ML et al. | Inclusion of flaxseed in hay- and barley silage diets increases alpha-linolenic acid in cow plasma independent of forage type. | 2011 | Lipids | pmid:21336984 |
| Palmieri-Thiers C et al. | Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. | 2011 | Arch. Biochem. Biophys. | pmid:21345329 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Popescu FD et al. | Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21328065 |
| Lee MJ et al. | The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. | 2011 | Mol. Cells | pmid:21331775 |
| Guesnet P and Alessandri JM | Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations. | 2011 | Biochimie | pmid:20478353 |
| Moltó-Puigmartà C et al. | Differences in fat content and fatty acid proportions among colostrum, transitional, and mature milk from women delivering very preterm, preterm, and term infants. | 2011 | Clin Nutr | pmid:20800325 |
| Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
| Nelson TL et al. | Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. | 2011 | Eur J Nutr | pmid:20706728 |
| Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
| Bassett CM et al. | The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21963840 |
| Niculescu MD et al. | Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. | 2011 | Int. J. Dev. Neurosci. | pmid:21964326 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Agnihotri G et al. | Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides. | 2011 | J. Med. Chem. | pmid:22007676 |
| Giltay EJ et al. | Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. | 2011 | Am. J. Clin. Nutr. | pmid:22030221 |
| McCullough RS et al. | The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression. | 2011 | Lipids | pmid:22031167 |
| Dewell A et al. | Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. | 2011 | J. Nutr. | pmid:22031659 |
| Banik M et al. | Transcript profiling and gene characterization of three fatty acid desaturase genes in high, moderate, and low linolenic acid genotypes of flax (Linum usitatissimum L.) and their role in linolenic acid accumulation. | 2011 | Genome | pmid:21627464 |
| Beaulieu A et al. | Leptin reverts pro-apoptotic and antiproliferative effects of α-linolenic acids in BCR-ABL positive leukemic cells: involvement of PI3K pathway. | 2011 | PLoS ONE | pmid:21991326 |
| Letona AZ et al. | CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. | 2011 | J. Nutr. | pmid:21628634 |
| Svensson J et al. | Postprandial lipid responses to an alpha-linolenic acid-rich oil, olive oil and butter in women: a randomized crossover trial. | 2011 | Lipids Health Dis | pmid:21711508 |
| Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
| Cuello S et al. | Comparative study of antioxidant and anti-inflammatory activities and genotoxicity of alcoholic and aqueous extracts of four Fabiana species that grow in mountainous area of Argentina. | 2011 | J Ethnopharmacol | pmid:21693175 |
| Miranda J et al. | cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA mixture activates PPARα in HEK293 and reduces triacylglycerols in 3T3-L1 cells. | 2011 | Lipids | pmid:21984112 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Rapoport SI et al. | Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21704722 |
| Qi J et al. | The chloroplast-localized phospholipases D α4 and α5 regulate herbivore-induced direct and indirect defenses in rice. | 2011 | Plant Physiol. | pmid:21984727 |
| Saha SS and Ghosh M | Antioxidant effect of vegetable oils containing conjugated linolenic acid isomers against induced tissue lipid peroxidation and inflammation in rat model. | 2011 | Chem. Biol. Interact. | pmid:21382362 |
| Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
| Michaelsen KF et al. | Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. | 2011 | Matern Child Nutr | pmid:21366872 |
| Degen C et al. | Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. | 2011 | Biochim. Biophys. Acta | pmid:21889998 |
| Yalcin H et al. | Effect of γ-irradiation on bioactivity, fatty acid compositions and volatile compounds of clary sage seed (Salvia sclarea L.). | 2011 | J. Food Sci. | pmid:22417543 |
| Berasategi I et al. | "High in omega-3 fatty acids" bologna-type sausages stabilized with an aqueous-ethanol extract of Melissa officinalis. | 2011 | Meat Sci. | pmid:21439735 |
| Jung DM et al. | A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. | 2011 | J. Food Sci. | pmid:22417487 |
| Kiyota R et al. | Biosynthetic pathways of the sex pheromone components and substrate selectivity of the oxidation enzymes working in pheromone glands of the fall webworm, Hyphantria cunea. | 2011 | Insect Biochem. Mol. Biol. | pmid:21338674 |
| Singh KK et al. | Flaxseed: a potential source of food, feed and fiber. | 2011 | Crit Rev Food Sci Nutr | pmid:21390942 |
| Barros R et al. | Dietary intake of α-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control. | 2011 | Br. J. Nutr. | pmid:21443816 |
| He L et al. | Preparation of SiO2/(PMMA/Fe3O4) nanoparticles using linolenic acid as crosslink agent for nucleic acid detection using chemiluminescent method. | 2011 | J Nanosci Nanotechnol | pmid:21449377 |
| Lin YH et al. | Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. | 2011 | J. Nutr. Biochem. | pmid:21111595 |
| Gopinath B et al. | Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality. | 2011 | Am. J. Clin. Nutr. | pmid:21411616 |
| Milberg P et al. | Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. | 2011 | Heart Rhythm | pmid:21459164 |
| López-López I et al. | Effect of cooking on the chemical composition of low-salt, low-fat Wakame/olive oil added beef patties with special reference to fatty acid content. | 2011 | Meat Sci. | pmid:21497025 |
| Gorissen L et al. | Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. | 2011 | Commun. Agric. Appl. Biol. Sci. | pmid:21539185 |
| Antruejo A et al. | Omega-3 enriched egg production: the effect of α -linolenic ω -3 fatty acid sources on laying hen performance and yolk lipid content and fatty acid composition. | 2011 | Br. Poult. Sci. | pmid:22221241 |
| Farina EK et al. | Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. | 2011 | J. Nutr. | pmid:21508210 |
| Diwakar BT et al. | Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. | 2011 | Br. J. Nutr. | pmid:21521541 |
| de Goede J et al. | Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. | 2011 | PLoS ONE | pmid:21464993 |
| Moltó-Puigmartà C et al. | Additional data from our study on fatty acids variations during lactation: correlations between n-3 and n-6 PUFAs in human colostrum, transitional, and mature milk. | 2011 | Clin Nutr | pmid:21470725 |
| Huang YQ et al. | Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. | 2011 | Analyst | pmid:21331428 |
| Park MH et al. | Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens var. japonica). | 2011 | J. Food Sci. | pmid:21623788 |
| Kapich AN et al. | Comparative evaluation of manganese peroxidase- and Mn(III)-initiated peroxidation of C18 unsaturated fatty acids by different methods. | 2011 | Enzyme Microb. Technol. | pmid:22112267 |
| Huang F et al. | EPA inhibits the inhibitor of κBα (IκBα)/NF-κB/muscle RING finger 1 pathway in C2C12 myotubes in a PPARγ-dependent manner. | 2011 | Br. J. Nutr. | pmid:20955633 |
| Metwal N et al. | Influence of debittered, defatted fenugreek seed powder and flaxseed powder on the rheological characteristics of dough and quality of cookies. | 2011 | Int J Food Sci Nutr | pmid:21250900 |
| Myhrstad MC et al. | Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. | 2011 | Br. J. Nutr. | pmid:21736782 |
| Egert S and Stehle P | Impact of n-3 fatty acids on endothelial function: results from human interventions studies. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21252652 |
| Brinkman MT et al. | Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study. | 2011 | Br. J. Nutr. | pmid:21736846 |
| Gopinath B et al. | Consumption of long-chain n-3 PUFA, α-linolenic acid and fish is associated with the prevalence of chronic kidney disease. | 2011 | Br. J. Nutr. | pmid:21255476 |
| Arshad A et al. | Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. | 2011 | Br. J. Nutr. | pmid:21745426 |
| Hayirli A et al. | Peripartum responses of dairy cows to prepartal feeding level and dietary fatty acid source. | 2011 | J. Dairy Sci. | pmid:21257060 |
| Dang HT et al. | Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads. | 2011 | Bioorg. Med. Chem. | pmid:21257314 |
| Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
| Qiu J et al. | Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus. | 2011 | PLoS ONE | pmid:21283822 |
| Zhang Y et al. | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21787405 |
| Winnik S et al. | Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. | 2011 | Eur. Heart J. | pmid:21285075 |
| Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
| Barden A et al. | The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function. | 2011 | Free Radic. Res. | pmid:21235285 |
| O'Neill CM et al. | Two high linolenic mutants of Arabidopsis thaliana contain megabase-scale genome duplications encompassing the FAD3 locus. | 2011 | Plant J. | pmid:21848868 |
| Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
| Zhao J et al. | Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. | 2011 | J. Nutr. Biochem. | pmid:21129946 |
| Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |
| Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
| Imhoff-Kunsch B et al. | Docosahexaenoic acid supplementation from mid-pregnancy to parturition influenced breast milk fatty acid concentrations at 1 month postpartum in Mexican women. | 2011 | J. Nutr. | pmid:21178076 |
| Hennessy AA et al. | The health promoting properties of the conjugated isomers of α-linolenic acid. | 2011 | Lipids | pmid:21161605 |
| Jungheim ES et al. | Elevated serum α-linolenic acid levels are associated with decreased chance of pregnancy after in vitro fertilization. | 2011 | Fertil. Steril. | pmid:21840520 |
| Hejazi L et al. | Identification of the geometrical isomers of α-linolenic acid using gas chromatography/mass spectrometry with a binary decision tree. | 2011 | Talanta | pmid:21215858 |
| Burdge GC | Polyunsaturated fatty acid intakes and α-linolenic acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:21191139 |
| Miyazawa D et al. | Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. | 2011 | Biomed. Res. | pmid:21878731 |
| Vigeolas H et al. | Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants. | 2011 | Plant Physiol. | pmid:21205621 |
| Mazaki-Tovi M et al. | Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. | 2011 | Am. J. Vet. Res. | pmid:21879986 |
| Couëdelo L et al. | Lymphatic absorption of α-linolenic acid in rats fed flaxseed oil-based emulsion. | 2011 | Br. J. Nutr. | pmid:21080982 |
| Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
| Lenka SK et al. | Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. | 2011 | Plant Biotechnol. J. | pmid:20809928 |
| Zhang W et al. | Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21908709 |
| Holy EW et al. | Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21571683 |
| Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
| Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
| Leyva DR et al. | The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: rationale and design of the FLAX-PAD randomized controlled trial. | 2011 | Contemp Clin Trials | pmid:21616170 |
| Feskens EJ | The prevention of type 2 diabetes: should we recommend vegetable oils instead of fatty fish? | 2011 | Am. J. Clin. Nutr. | pmid:21733879 |
| Sakurai K et al. | Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice. | 2011 | Nephron Exp. Nephrol. | pmid:21734409 |
| Xie N et al. | α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. | 2011 | Arch. Med. Res. | pmid:21722811 |
| Sampels S et al. | Fatty acid transfer from sow to piglet differs for different polyunsaturated fatty acids (PUFA). | 2011 | Physiol Res | pmid:20945951 |
| Carrillo C et al. | Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. | 2011 | Cell. Physiol. Biochem. | pmid:21471726 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
| Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
| Senadheera SD et al. | Effects of dietary α-linolenic acid (18:3n-3)/linoleic acid (18:2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii). | 2011 | J. Agric. Food Chem. | pmid:21222433 |
| Lee YJ and Jenkins TC | Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. | 2011 | J. Nutr. | pmid:21653571 |