| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Amyloidosis | D000686 | 4 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Atrial Fibrillation | D001281 | 16 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Taha AY et al. | Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. | 2009 | Epilepsia | pmid:18657173 |
| Porta N et al. | Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. | 2009 | Epilepsia | pmid:18657178 |
| Taha AY et al. | Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. | 2006 | Epilepsy Res. | pmid:16787740 |
| Schwab US et al. | The effect of quality and amount of dietary fat on the susceptibility of low density lipoprotein to oxidation in subjects with impaired glucose tolerance. | 1998 | Eur J Clin Nutr | pmid:9683400 |
| Bere E | Wild berries: a good source of omega-3. | 2007 | Eur J Clin Nutr | pmid:16900081 |
| Perng W et al. | Alpha-linolenic acid (ALA) is inversely related to development of adiposity in school-age children. | 2015 | Eur J Clin Nutr | pmid:25271016 |
| Cespedes E et al. | Adipose tissue n-3 fatty acids and metabolic syndrome. | 2015 | Eur J Clin Nutr | pmid:25097001 |
| Patenaude A et al. | Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject. | 2009 | Eur J Clin Nutr | pmid:19584895 |
| Rodriguez A et al. | Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. | 2003 | Eur J Clin Nutr | pmid:12792656 |
| Bemelmans WJ et al. | Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. | 2004 | Eur J Clin Nutr | pmid:15220952 |
| Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
| Valsta LM et al. | Alpha-linolenic acid in rapeseed oil partly compensates for the effect of fish restriction on plasma long chain n-3 fatty acids. | 1996 | Eur J Clin Nutr | pmid:8730609 |
| López-López A et al. | Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. | 2002 | Eur J Clin Nutr | pmid:12494309 |
| Becker CC et al. | Effects of butter oil blends with increased concentrations of stearic, oleic and linolenic acid on blood lipids in young adults. | 1999 | Eur J Clin Nutr | pmid:10452408 |
| Oya J et al. | Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. | 2010 | Eur J Clin Nutr | pmid:20683463 |
| Thomas T et al. | The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. | 2012 | Eur J Clin Nutr | pmid:22009072 |
| Billeaud C et al. | Effects of preterm infant formula supplementation with alpha-linolenic acid with a linoleate/alpha-linolenate ratio of 6: a multicentric study. | 1997 | Eur J Clin Nutr | pmid:11248877 |
| Zeleniuch-Jacquotte A et al. | Reliability of fatty acid composition in human serum phospholipids. | 2000 | Eur J Clin Nutr | pmid:10822282 |
| Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
| Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
| Tarpila S et al. | The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. | 2002 | Eur J Clin Nutr | pmid:11857049 |
| Egert S et al. | Influence of three rapeseed oil-rich diets, fortified with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers. | 2007 | Eur J Clin Nutr | pmid:16969378 |
| Babin F et al. | Alpha linolenic acid in cholesterol esters: a marker of alphalinolenic acid intake in newborns. | 2000 | Eur J Clin Nutr | pmid:11114678 |
| Voskuil DW et al. | Intake and sources of alpha-linolenic acid in Dutch elderly men. | 1996 | Eur J Clin Nutr | pmid:8968698 |
| MartÃnez-Ortiz JA et al. | Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults. | 2006 | Eur J Clin Nutr | pmid:16465200 |
| Mamalakis G et al. | Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. | 2006 | Eur J Clin Nutr | pmid:16482070 |
| Goyens PL and Mensink RP | Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. | 2006 | Eur J Clin Nutr | pmid:16482073 |
| Astorg P et al. | Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. | 2008 | Eur J Clin Nutr | pmid:17622261 |
| Sébédio JL et al. | The effect of dietary trans alpha-linolenic acid on plasma lipids and platelet fatty acid composition: the TransLinE study. | 2000 | Eur J Clin Nutr | pmid:10694780 |
| Paschos GK et al. | Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. | 2007 | Eur J Clin Nutr | pmid:17268413 |
| Djoussé L et al. | Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. | 2014 | Eur J Nutr | pmid:24395612 |
| Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
| Morise A et al. | Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARalpha in male and female mice. | 2009 | Eur J Nutr | pmid:19588182 |
| Warstedt K and Duchén K | Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. | 2013 | Eur J Nutr | pmid:22584414 |
| Nelson TL et al. | Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. | 2011 | Eur J Nutr | pmid:20706728 |
| Alessandri JM et al. | Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. | 2012 | Eur J Nutr | pmid:21647669 |
| Paschos GK et al. | Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. | 2007 | Eur J Nutr | pmid:17623225 |
| Trommer H et al. | The examination of skin lipid model systems stressed by ultraviolet irradiation in the presence of transition metal ions. | 2001 | Eur J Pharm Biopharm | pmid:11343884 |
| Koh AS et al. | The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. | 2015 | Eur J Prev Cardiol | pmid:24343844 |
| Winnik S et al. | Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. | 2011 | Eur. Heart J. | pmid:21285075 |
| Schaffrath U et al. | Characterization of RCI-1, a chloroplastic rice lipoxygenase whose synthesis is induced by chemical plant resistance activators. | 2000 | Eur. J. Biochem. | pmid:10998053 |
| Antras-Ferry J et al. | Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes. | 1995 | Eur. J. Biochem. | pmid:8536680 |
| MartÃn M et al. | Antisense-mediated depletion of potato leaf omega3 fatty acid desaturase lowers linolenic acid content and reduces gene activation in response to wounding. | 1999 | Eur. J. Biochem. | pmid:10336609 |
| Bartsch H and Nair J | New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies. | 2000 | Eur. J. Cancer | pmid:10882861 |
| Klein V et al. | Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. | 2000 | Eur. J. Cancer | pmid:10708934 |
| Steer P et al. | Endothelial vasodilatory function is related to the proportions of saturated fatty acids and alpha-linolenic acid in young men, but not in women. | 2003 | Eur. J. Clin. Invest. | pmid:12713452 |
| Zatonski W et al. | Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid. | 2008 | Eur. J. Epidemiol. | pmid:17955332 |
| Lauretani F et al. | Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. | 2007 | Eur. J. Neurol. | pmid:17594339 |
| Yehuda S et al. | Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. | 1994 | Eur. J. Pharmacol. | pmid:7911428 |
| Francès H et al. | Influence of a dietary alpha-linolenic acid deficiency on learning in the Morris water maze and on the effects of morphine. | 1996 | Eur. J. Pharmacol. | pmid:8846819 |
| Katsoulieris E et al. | alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress. | 2009 | Eur. J. Pharmacol. | pmid:19765573 |
| Yehuda S et al. | Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. | 1997 | Eur. J. Pharmacol. | pmid:9203563 |
| Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
| Sánchez-Reyes OB et al. | Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. | 2014 | Eur. J. Pharmacol. | pmid:24239485 |
| Cornish SM and Chilibeck PD | Multiple interventions for treating chronic inflammation in older adults: what is the best strategy? | 2010 | Exerc Sport Sci Rev | pmid:20335742 |
| Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
| Chen J et al. | Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. | 2007 | Exp. Biol. Med. (Maywood) | pmid:17720953 |
| Sonne DP and Knop FK | Cardiovascular effects of alpha-linolenic acid--a possible role of glucagon-like peptide-1. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24174423 |
| Simopoulos AP | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | 2008 | Exp. Biol. Med. (Maywood) | pmid:18408140 |
| Regensburger J et al. | Fatty acids and vitamins generate singlet oxygen under UVB irradiation. | 2012 | Exp. Dermatol. | pmid:22229443 |
| Mibu H et al. | A study on lipid peroxide-induced lens damage in vitro. | 1994 | Exp. Eye Res. | pmid:7908884 |
| Leung IY et al. | Nutritional manipulation of primate retinas. IV. Effects of n--3 fatty acids, lutein, and zeaxanthin on S-cones and rods in the foveal region. | 2005 | Exp. Eye Res. | pmid:15916761 |
| Eisinger K et al. | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Exp. Mol. Pathol. | pmid:24830603 |
| Smith HL et al. | Development of a serum-free system for the in vitro cultivation of Brugia malayi infective-stage larvae. | 2000 | Exp. Parasitol. | pmid:11038308 |
| Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
| Cave WT | Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis. | 1991 | FASEB J. | pmid:1673664 |
| Niculescu MD et al. | Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. | 2013 | FASEB J. | pmid:22997227 |
| Tanaka T et al. | Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells. | 2007 | FEBS J. | pmid:17451430 |
| Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
| Rossi M et al. | Growth, lipid accumulation, and fatty acid composition in obligate psychrophilic, facultative psychrophilic, and mesophilic yeasts. | 2009 | FEMS Microbiol. Ecol. | pmid:19624740 |
| Laoteng K et al. | A Mucor rouxii mutant with high accumulation of an unusual trans-linoleic acid (9c,12t-C18:2). | 2003 | FEMS Microbiol. Lett. | pmid:12829281 |
| de Freitas JM et al. | Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. | 2012 | FEMS Yeast Res. | pmid:22846157 |
| Lissak A et al. | Oxidative stress indices in seminal plasma, as measured by the thermochemiluminescence assay, correlate with sperm parameters. | 2004 | Fertil. Steril. | pmid:15019811 |
| Jungheim ES et al. | Elevated serum α-linolenic acid levels are associated with decreased chance of pregnancy after in vitro fertilization. | 2011 | Fertil. Steril. | pmid:21840520 |
| Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
| Kowalska A et al. | Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). | 2012 | Fish Physiol. Biochem. | pmid:21656178 |
| Oberthür C et al. | HPLC based activity profiling for 5-lipoxygenase inhibitory activity in Isatis tinctoria leaf extracts. | 2005 | Fitoterapia | pmid:15893435 |
| Kukoba TV et al. | [The effects of alpha-linolenic acid on the functioning of the isolated heart during acute myocardial ischemia/reperfusion]. | 2006 | Fiziol Zh | pmid:17176834 |
| Molkentin J | Applicability of organic milk indicators to the authentication of processed products. | 2013 | Food Chem | pmid:23199986 |
| Carbonera F et al. | Effect of dietary replacement of sunflower oil with perilla oil on the absolute fatty acid composition in Nile tilapia (GIFT). | 2014 | Food Chem | pmid:24262550 |
| Garcia CV et al. | Characterisation of bound volatile compounds of a low flavour kiwifruit species: Actinidia eriantha. | 2012 | Food Chem | pmid:23107675 |
| Umesha SS and Naidu KA | Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. | 2012 | Food Chem | pmid:22980881 |
| Gómez-Cortés P et al. | Novel characterisation of minor α-linolenic acid isomers in linseed oil by gas chromatography and covalent adduct chemical ionisation tandem mass spectrometry. | 2016 | Food Chem | pmid:26830571 |
| Wiesenfeld PW et al. | Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. | 2003 | Food Chem. Toxicol. | pmid:12738189 |
| Babu US et al. | Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. | 2003 | Food Chem. Toxicol. | pmid:12738196 |
| Saha SS and Ghosh M | Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model. | 2010 | Food Chem. Toxicol. | pmid:20851731 |
| Pal M and Ghosh M | Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. | 2012 | Food Chem. Toxicol. | pmid:22269903 |
| Pal M and Ghosh M | Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. | 2012 | Food Chem. Toxicol. | pmid:22683484 |
| Nakamura YK et al. | Modulation of oxidative stress by γ-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells. | 2012 | Food Chem. Toxicol. | pmid:22490668 |
| Chang HH et al. | Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. | 2009 | Food Chem. Toxicol. | pmid:19271319 |
| Coles L et al. | A model to predict the ATP equivalents of macronutrients absorbed from food. | 2013 | Food Funct | pmid:23233079 |
| González-Mañán D et al. | Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl Coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils. | 2012 | Food Funct | pmid:22588205 |
| Folino A et al. | Alpha-linolenic acid protects against cardiac injury and remodelling induced by beta-adrenergic overstimulation. | 2015 | Food Funct | pmid:26068025 |
| Pawlosky RJ et al. | Methods for determining the metabolism of alpha-linolenic acid in human subjects from intrinsically-labeled food. | 2003 | Forum Nutr | pmid:15806804 |
| Qian SY et al. | Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12826254 |
| Dikalov SI and Mason RP | Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. | 2001 | Free Radic. Biol. Med. | pmid:11163536 |
| Sharov VS et al. | Selective sensitization of chemiluminescence resulted from lipid and oxygen radical reactions. | 1989 | Free Radic. Biol. Med. | pmid:2570736 |
| Sugihara N et al. | Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. | 1999 | Free Radic. Biol. Med. | pmid:10641726 |
| Iliou JP et al. | Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage. | 1995 | Free Radic. Biol. Med. | pmid:8582650 |
| Imbusch R and Mueller MJ | Formation of isoprostane F(2)-like compounds (phytoprostanes F(1)) from alpha-linolenic acid in plants. | 2000 | Free Radic. Biol. Med. | pmid:10754267 |