| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang DQ et al. | [Alpha-linolenic acid improves insulin sensitivity in obese patients]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:23648351 |
| Dai CC et al. | [Comparative studies on the fatty acids contained in four species of medicinal plants from family Euphorbiaceae and their endophytic fungi]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776425 |
| Zhang LH et al. | [Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]. | 2012 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22493899 |
| Tan X et al. | [Supercritical-CO2 fluid extraction of fatty oils from Perilla frutescens seeds and pharmacological study]. | 1999 | Zhong Yao Cai | pmid:12571915 |
| Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
| Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
| Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
| Dobos G and Michalsen A | [Comment on the contribution by G. Keyser, "Are there reliable dietary recommendations for patients with rheumatoid arthritis?"]. | 2001 | Z Rheumatol | pmid:11584725 |
| Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
| Kim DH et al. | Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. | 2012 | Yonsei Med. J. | pmid:23074118 |
| He J et al. | Correlation of polyunsaturated fatty acids with the cold adaptation of Rhodotorula glutinis. | 2015 | Yeast | pmid:26284451 |
| Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
| Kainou K et al. | Isolation of Delta12 and omega3-fatty acid desaturase genes from the yeast Kluyveromyces lactis and their heterologous expression to produce linoleic and alpha-linolenic acids in Saccharomyces cerevisiae. | 2006 | Yeast | pmid:16823888 |
| Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
| Cardoso CR et al. | Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. | 2004 Mar-Apr | Wound Repair Regen | pmid:15086775 |
| Moore SA | Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid. | 1994 | World Rev Nutr Diet | pmid:7871814 |
| Calder PC | omega 3 polyunsaturated fatty acids, inflammation and immunity. | 2001 | World Rev Nutr Diet | pmid:11935943 |
| Williard DE et al. | Production and release of docosahexaenoic acid by differentiated rat brain astrocytes. | 2001 | World Rev Nutr Diet | pmid:11935950 |
| Bjerve KS | Omega 3 fatty acid deficiency in man: implications for the requirement of alpha-linolenic acid and long-chain omega 3 fatty acids. | 1991 | World Rev Nutr Diet | pmid:1675825 |
| Cunnane SC | New developments in alpha-linolenate metabolism with emphasis on the importance of beta-oxidation and carbon recycling. | 2001 | World Rev Nutr Diet | pmid:11935952 |
| Okuyama H et al. | alpha-linolenate-deficiency-induced alterations in brightness discrimination learning behavior and retinal function in rats. | 2001 | World Rev Nutr Diet | pmid:11935967 |
| Renaud SC and Lanzmann-Petithory D | alpha-linolenic acid in the prevention of cardiovascular diseases. | 2001 | World Rev Nutr Diet | pmid:11935975 |
| Howe PR | Omega 3 fatty acids--an Australian perspective. | 1998 | World Rev Nutr Diet | pmid:9648518 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Okuyama H et al. | Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. | 2007 | World Rev Nutr Diet | pmid:17167282 |
| Okuyama H et al. | Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? | 2007 | World Rev Nutr Diet | pmid:17167283 |
| Yang X et al. | [Effects of silkworm pupa oil on serum lipids level and platelet function in rats]. | 2002 | Wei Sheng Yan Jiu | pmid:12600031 |
| Jiang M et al. | [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. | 2012 | Wei Sheng Yan Jiu | pmid:22611923 |
| Zhang G et al. | [Effects of fatty acids on proliferation and differentiation of myoblast]. | 2012 | Wei Sheng Yan Jiu | pmid:23424861 |
| Fein A and Cavar S | Divergent mechanisms for phototransduction of invertebrate microvillar photoreceptors. | 2000 Nov-Dec | Vis. Neurosci. | pmid:11193107 |
| Johnston NW | Chronic degenerative radiculomyelopathy therapy. | 1985 Dec 21-28 | Vet. Rec. | pmid:2869606 |
| Thanasak J et al. | Effects of polyunsaturated fatty acids on the proliferation of mitogen stimulated bovine peripheral blood mononuclear cells. | 2005 | Vet. Immunol. Immunopathol. | pmid:15734550 |
| van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
| Leng GC et al. | Essential fatty acids and cardiovascular disease: the Edinburgh Artery Study. | 1999 | Vasc Med | pmid:10613625 |
| Zhang W et al. | Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. | 2013 | VASA | pmid:24220118 |
| Zakhariv OIa and Ianovych VH | [Use of [1-14C]linolenic acid in lipid synthesis in ruminant tissues during the prenatal and postnatal periods of development in vitro]. | 1993 Sep-Oct | Ukr. Biokhim. Zh. | pmid:7909179 |
| Nguyen LQ et al. | Intake of essential fatty acids by growing-finishing pigs kept on smallholdings in central Vietnam. | 2005 | Trop Anim Health Prod | pmid:15729898 |
| Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
| Caligiuri SP et al. | The HYPERFlax trial for determining the anti-HYPERtensive effects of dietary flaxseed in newly diagnosed stage 1 hypertensive patients: study protocol for a randomized, double-blinded, controlled clinical trial. | 2014 | Trials | pmid:24938224 |
| Weber H | Fatty acid-derived signals in plants. | 2002 | Trends Plant Sci. | pmid:11992827 |
| Blée E | Impact of phyto-oxylipins in plant defense. | 2002 | Trends Plant Sci. | pmid:12119169 |
| Bonaventure G et al. | Herbivore-associated elicitors: FAC signaling and metabolism. | 2011 | Trends Plant Sci. | pmid:21354852 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Flores T et al. | Silencing of GmFAD3 gene by siRNA leads to low alpha-linolenic acids (18:3) of fad3-mutant phenotype in soybean [Glycine max (Merr.)]. | 2008 | Transgenic Res. | pmid:18256901 |
| Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
| Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
| Sugihara N et al. | Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid. | 1997 | Toxicology | pmid:9160106 |
| Vanden Heuvel JP et al. | Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. | 2006 | Toxicol. Sci. | pmid:16731579 |
| Steinritz D et al. | Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation. | 2010 | Toxicol. Sci. | pmid:20833707 |
| Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
| Wiest EF et al. | Association of serum aryl hydrocarbon receptor activity and RBC omega-3 polyunsaturated fatty acids with flow-mediated dilation in healthy, young Hispanic cigarette smokers. | 2015 | Toxicol. Lett. | pmid:25482063 |
| Kudo N and Kawashima Y | Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9266801 |
| Suji G and Sivakami S | Malondialdehyde, a lipid-derived aldehyde alters the reactivity of Cys34 and the esterase activity of serum albumin. | 2008 | Toxicol In Vitro | pmid:18206343 |
| Sakayori N et al. | Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice. | 2016 | Tohoku J. Exp. Med. | pmid:27558477 |
| Torinuki W et al. | Chemiluminescence of UV-irradiated linolenic acid and squalene. | 1982 | Tohoku J. Exp. Med. | pmid:6280339 |
| Bjerve KS et al. | [Essential linolenic fatty acid deficiency. Patients on long-term gastric tube feeding]. | 1986 | Tidsskr. Nor. Laegeforen. | pmid:2880408 |
| Johnson LK et al. | [Diet and secondary prevention of coronary heart disease--are our recommendations good enough?]. | 2001 | Tidsskr. Nor. Laegeforen. | pmid:11354888 |
| Pedersen JI | [Does alpha-linolenic acid prevent cardiac death?]. | 2006 | Tidsskr. Nor. Laegeforen. | pmid:17086215 |
| Landmark K and Alm CS | [Alpha-linolenic acid, cardiovascular disease and sudden death]. | 2006 | Tidsskr. Nor. Laegeforen. | pmid:17086218 |
| Armstrong RA et al. | No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. | 2000 | Thromb. Res. | pmid:11108899 |
| Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
| Kemp B et al. | Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. | 1998 | Theriogenology | pmid:10732036 |
| Colazo MG et al. | Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed. | 2004 | Theriogenology | pmid:15036999 |
| Hu X et al. | Mapping of the loci controlling oleic and linolenic acid contents and development of fad2 and fad3 allele-specific markers in canola (Brassica napus L.). | 2006 | Theor. Appl. Genet. | pmid:16767448 |
| Yang Q et al. | Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. | 2012 | Theor. Appl. Genet. | pmid:22534790 |
| Soto-Cerda BJ et al. | Association mapping of seed quality traits using the Canadian flax (Linum usitatissimum L.) core collection. | 2014 | Theor. Appl. Genet. | pmid:24463785 |
| Han Y et al. | Dynamic QTL analysis of linolenic acid content in different developmental stages of soybean seed. | 2011 | Theor. Appl. Genet. | pmid:21344183 |
| Pham AT et al. | Combinations of mutant FAD2 and FAD3 genes to produce high oleic acid and low linolenic acid soybean oil. | 2012 | Theor. Appl. Genet. | pmid:22476873 |
| Rahman H et al. | Development of low-linolenic acid Brassica oleracea lines through seed mutagenesis and molecular characterization of mutants. | 2013 | Theor. Appl. Genet. | pmid:23475317 |
| Nakamura K and Uemura D | [Unelucidated biological phenomena]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:18051396 |
| Ozawa R | [Herbivore elicitors and plant signaling pathways involved in the production of herbivore-induced plant volatiles]. | 2003 | Tanpakushitsu Kakusan Koso | pmid:14535205 |
| Hejazi L et al. | Identification of the geometrical isomers of α-linolenic acid using gas chromatography/mass spectrometry with a binary decision tree. | 2011 | Talanta | pmid:21215858 |
| Schreck U et al. | Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? | 2002 | Strahlenther Onkol | pmid:12122788 |
| Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
| Hisha H et al. | Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-taiho-to): stimulatory effects of its fatty acids on hemopoiesis in patients. | 2002 | Stem Cells | pmid:12110700 |
| Chambron E | [Dietetics in coronary patients]. | 2005 | Soins | pmid:15999643 |
| Trommer H et al. | Mass spectrometric examinations of stratum corneum lipid models exposed to ultraviolet irradiation. | 2003 Sep-Oct | Skin Pharmacol. Appl. Skin Physiol. | pmid:12907834 |
| Larsson-Backström C et al. | Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. | 1995 | Shock | pmid:7552772 |
| Zhang HT et al. | [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. | 2006 | Sheng Wu Gong Cheng Xue Bao | pmid:16572837 |
| Liu L et al. | [Expression of delta 6-fatty acid desaturase gene from Mortierella alpina in Saccharomyces cerevisiae]. | 2001 | Sheng Wu Gong Cheng Xue Bao | pmid:11411223 |
| Fan WX | [Alpha-linolenic acid and its metabolites EPA and DHA]. | 1988 | Sheng Li Ke Xue Jin Zhan | pmid:2901141 |
| Uauy R and Hoffman DR | Essential fatty acid requirements for normal eye and brain development. | 1991 | Semin. Perinatol. | pmid:1687090 |
| Wang Q et al. | [Determination of alpha-linolenic acid in perilla oil by reversed-phase high performance liquid chromatography coupled with evaporative light-scattering detector]. | 2006 | Se Pu | pmid:16827313 |
| Cui K et al. | [Analysis of triacylglycerol composition of perilla oil by combination of non-aqueous reversed-phase high performance liquid chromatography with gas chromatography]. | 1997 | Se Pu | pmid:15739324 |
| Bellaloui N and Mengistu A | Effects of boron nutrition and water stress on nitrogen fixation, seed δ15N and δ13C dynamics, and seed composition in soybean cultivars differing in maturities. | 2015 | ScientificWorldJournal | pmid:25667936 |
| KORN ED and GREENBLATT CL | SYNTHESIS OF ALPHA-LINOLENIC ACID BY LEISHMANIA ENRIETTII. | 1963 | Science | pmid:14074842 |
| Liechti R and Farmer EE | Jasmonate biochemical pathway. | 2006 | Sci. STKE | pmid:16478937 |
| Fu X et al. | Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. | 2015 | Sci Rep | pmid:26567525 |
| Wu MH et al. | A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. | 2014 | Sci Rep | pmid:24651079 |
| Liu X et al. | APA-style human milk fat analogue from silkworm pupae oil: Enzymatic production and improving storage stability using alkyl caffeates. | 2015 | Sci Rep | pmid:26643045 |
| McNamara RK et al. | Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. | 2009 | Schizophr. Res. | pmid:18993032 |
| Dybkowska E et al. | [The comparison of fat, trans isomers and cholesterol intake in the diet of Warsaw inhabitants in relation to Polish food ration]. | 2004 | Rocz Panstw Zakl Hig | pmid:19097583 |
| Sato M et al. | [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. | 1986 | Rinsho Shinkeigaku | pmid:2879661 |
| Nordström DC et al. | Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. | 1995 | Rheumatol. Int. | pmid:7597378 |
| Ulbricht C et al. | Chia (Salvia hispanica): a systematic review by the natural standard research collaboration. | 2009 | Rev Recent Clin Trials | pmid:20028328 |
| MandaÅŸescu S et al. | Flaxseed supplementation in hyperlipidemic patients. | 2005 Jul-Sep | Rev Med Chir Soc Med Nat Iasi | pmid:16607740 |
| Glocker TM | [Pathology of placenta of rats induced by fatty acid deficiency]. | 2000 | Rev Fac Cien Med Univ Nac Cordoba | pmid:12934235 |
| Smith GM and Isopenko A | Effect of doses of protected polyunsaturated fatty acids on indicators of selenium status of sheep. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160431 |
| Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
| Robinson RS et al. | Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. | 2002 | Reproduction | pmid:12090925 |