Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Reinprecht Y et al. | Seed and agronomic QTL in low linolenic acid, lipoxygenase-free soybean (Glycine max (L.) Merrill) germplasm. | 2006 | Genome | pmid:17426766 |
Griffin MD et al. | Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. | 2006 | Am. J. Clin. Nutr. | pmid:17158408 |
Harper CR et al. | Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. | 2006 | J. Nutr. | pmid:17056811 |
de Lorgeril M and Salen P | The Mediterranean diet in secondary prevention of coronary heart disease. | 2006 | Clin Invest Med | pmid:17058434 |
Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
Dabadie H et al. | Variations in daily intakes of myristic and alpha-linolenic acids in sn-2 position modify lipid profile and red blood cell membrane fluidity. | 2006 | Br. J. Nutr. | pmid:16923222 |
I take ground flaxseed to help control my cholesterol. But I read that the alpha-linoleic acid (ALA) in flax increases the risk of prostate cancer. Is this true? Does the risk differ between ground flaxseed and concentrated flaxseed oil in capsules? | 2006 | Johns Hopkins Med Lett Health After 50 | pmid:16548073 | |
Blanco M et al. | Ischemic preconditioning: a novel target for neuroprotective therapy. | 2006 | Cerebrovasc. Dis. | pmid:16651813 |
Shanker KS et al. | Isolation and characterization of neutral lipids of desilked eri silkworm pupae grown on castor and tapioca leaves. | 2006 | J. Agric. Food Chem. | pmid:16637689 |
Cristea M and Oliw EH | A G316A mutation of manganese lipoxygenase augments hydroperoxide isomerase activity: mechanism of biosynthesis of epoxyalcohols. | 2006 | J. Biol. Chem. | pmid:16641090 |
King VR et al. | Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. | 2006 | J. Neurosci. | pmid:16641248 |
Heller AR et al. | Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. | 2006 | Anesth. Analg. | pmid:16551943 |
Djoussé L et al. | Influence of saturated fat and linolenic acid on the association between intake of dairy products and blood pressure. | 2006 | Hypertension | pmid:16801477 |
Cancelo Hidalgo MJ et al. | Effect of a compound containing isoflavones, primrose oil and vitamin E in two different doses on climacteric symptoms. | 2006 | J Obstet Gynaecol | pmid:16753687 |
Martin CA et al. | Trans polyunsaturated fatty acid contents in Brazilian refined soybean oil. | 2006 | Anal Sci | pmid:16760612 |
Wang C et al. | n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. | 2006 | Am. J. Clin. Nutr. | pmid:16825676 |
Koralek DO et al. | A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). | 2006 | Cancer Causes Control | pmid:16783606 |
Wang Q et al. | [Determination of alpha-linolenic acid in perilla oil by reversed-phase high performance liquid chromatography coupled with evaporative light-scattering detector]. | 2006 | Se Pu | pmid:16827313 |
Burdge GC | Metabolism of alpha-linolenic acid in humans. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16828546 |
Galli C and Marangoni F | N-3 fatty acids in the Mediterranean diet. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16837180 |
Hamada T et al. | Reduction of trienoic fatty acid content by expression of a double-stranded RNA of a plastid omega-3 fatty acid desaturase gene in transgenic tobacco. | 2006 | Biotechnol. Lett. | pmid:16786241 |
Taha AY et al. | Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. | 2006 | Epilepsy Res. | pmid:16787740 |
Hu X et al. | Mapping of the loci controlling oleic and linolenic acid contents and development of fad2 and fad3 allele-specific markers in canola (Brassica napus L.). | 2006 | Theor. Appl. Genet. | pmid:16767448 |
Bauer JE et al. | Docosahexaenoic acid accumulates in plasma of canine puppies raised on alpha-linolenic acid-rich milk during suckling but not when fed alpha-linolenic acid-rich diets after weaning. | 2006 | J. Nutr. | pmid:16772507 |
DiRienzo MA et al. | Effect of substitution of low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. | 2006 | Lipids | pmid:17707981 |
Arab K et al. | Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. | 2006 | Br. J. Nutr. | pmid:17092368 |
Aldámiz-EchevarrÃa L et al. | Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. | 2006 | J. Inherit. Metab. Dis. | pmid:16601869 |
Dhar P et al. | Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: an in vitro study. | 2006 | J Oleo Sci | pmid:17693694 |
Taha AY et al. | Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate. | 2006 | Lipids | pmid:17180881 |
Inouye S et al. | The vapor activity of oregano, perilla, tea tree, lavender, clove, and geranium oils against a Trichophyton mentagrophytes in a closed box. | 2006 | J. Infect. Chemother. | pmid:17235639 |
Kukoba TV et al. | [The effects of alpha-linolenic acid on the functioning of the isolated heart during acute myocardial ischemia/reperfusion]. | 2006 | Fiziol Zh | pmid:17176834 |
Joshi K et al. | Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16314082 |
Rodriguez-Cruz M et al. | Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1. | 2006 | J. Lipid Res. | pmid:16333142 |
Harper CR et al. | Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. | 2006 | J. Nutr. | pmid:16365063 |
Bourre JM et al. | Fatty acid alterations in liver peroxisomes from n-3-deficient mice. | 2006 | Ann. Nutr. Metab. | pmid:16407648 |
Vanden Heuvel JP et al. | Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. | 2006 | Toxicol. Sci. | pmid:16731579 |
Yao HT et al. | The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. | 2006 | Life Sci. | pmid:16978661 |
Leone A et al. | Lipoxygenase involvement in ripening strawberry. | 2006 | J. Agric. Food Chem. | pmid:16939347 |
Turpeinen AM et al. | Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man. | 2006 | Br. J. Nutr. | pmid:16571152 |
Perez MA et al. | Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. | 2006 | J. Nutr. Biochem. | pmid:16457997 |
Lehner F et al. | Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. | 2006 | J. Lipid Res. | pmid:16299352 |
Cunnane SC et al. | Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates. | 2006 | Pediatr. Res. | pmid:16326997 |
Langdon JH | Has an aquatic diet been necessary for hominin brain evolution and functional development? | 2006 | Br. J. Nutr. | pmid:16869985 |
Maillard V et al. | Dietary beta-carotene inhibits mammary carcinogenesis in rats depending on dietary alpha-linolenic acid content. | 2006 | Br. J. Nutr. | pmid:16869986 |
Moore CS et al. | Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. | 2006 | Nutrition | pmid:17027436 |
Zhang HT et al. | [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. | 2006 | Sheng Wu Gong Cheng Xue Bao | pmid:16572837 |
Sebei K et al. | Evolution of phosphoenolpyruvate carboxylase activity and lipid content during seed maturation of two spring rapeseed cultivars (Brassica napus L.). | 2006 | C. R. Biol. | pmid:16945838 |
Xiang M et al. | Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. | 2006 | Ann. Nutr. Metab. | pmid:16988497 |
Wendland E et al. | Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review. | 2006 | Heart | pmid:15890766 |
Yasui Y et al. | Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. | 2006 | Chemotherapy | pmid:16899971 |
Murayama SY et al. | Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. | 2006 | Microbiology (Reading, Engl.) | pmid:16622072 |
Hoffman DR et al. | Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540798 |
Tsuzuki T et al. | Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. | 2006 | J. Nutr. | pmid:16857834 |
Levant B et al. | Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. | 2006 | J. Nutr. | pmid:16857847 |
Djoussé L et al. | Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. | 2006 | Obesity (Silver Spring) | pmid:16571856 |
Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
DeFilippis AP and Sperling LS | Understanding omega-3's. | 2006 | Am. Heart J. | pmid:16504616 |
MartÃnez-Ortiz JA et al. | Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults. | 2006 | Eur J Clin Nutr | pmid:16465200 |
Kainou K et al. | Isolation of Delta12 and omega3-fatty acid desaturase genes from the yeast Kluyveromyces lactis and their heterologous expression to produce linoleic and alpha-linolenic acids in Saccharomyces cerevisiae. | 2006 | Yeast | pmid:16823888 |
Liechti R and Farmer EE | Jasmonate biochemical pathway. | 2006 | Sci. STKE | pmid:16478937 |
Mamalakis G et al. | Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. | 2006 | Eur J Clin Nutr | pmid:16482070 |
Goyens PL et al. | Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. | 2006 | Am. J. Clin. Nutr. | pmid:16825680 |
Goyens PL and Mensink RP | Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. | 2006 | Eur J Clin Nutr | pmid:16482073 |
Mayes C et al. | Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. | 2006 | Pediatr. Res. | pmid:16439591 |
Sanjurjo P et al. | Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. | 2006 | Br. J. Nutr. | pmid:16441930 |
Williams CM and Burdge G | Long-chain n-3 PUFA: plant v. marine sources. | 2006 | Proc Nutr Soc | pmid:16441943 |
Christensen JH et al. | Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. | 2006 | BJU Int. | pmid:16430627 |
Oliw EH et al. | Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. | 2006 | Anal. Biochem. | pmid:16712763 |
Hamazaki K et al. | Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. | 2006 | Nutrition | pmid:16472981 |
Dalen KT et al. | PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. | 2006 | J. Lipid Res. | pmid:16489205 |
Vijaimohan K et al. | Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. | 2006 | Life Sci. | pmid:16490217 |
Sánchez-Hernández C et al. | Reduced levels of volatile emissions in jasmonate-deficient spr2 tomato mutants favour oviposition by insect herbivores. | 2006 | Plant Cell Environ. | pmid:17080606 |
Nannicini F et al. | Alpha-linolenic acid and cardiovascular diseases omega-3 fatty acids beyond eicosapentaenoic acid and docosahexaenoic acid. | 2006 | Minerva Cardioangiol | pmid:17016414 |
Villarroel M et al. | [Development of an optimized formulation of flaxseed (Linum usitatissimum) mousse]. | 2006 | Arch Latinoam Nutr | pmid:17024965 |
Alessandri C et al. | Alpha-linolenic acid-rich wheat germ oil decreases oxidative stress and CD40 ligand in patients with mild hypercholesterolemia. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:17053175 |
Erkkilä AT et al. | Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. | 2006 | J. Lipid Res. | pmid:16983146 |
Burdge GC and Calder PC | Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188209 |
Mozaffarian D | Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence. | 2005 May-Jun | Altern Ther Health Med | pmid:15945135 |
MandaÅŸescu S et al. | Flaxseed supplementation in hyperlipidemic patients. | 2005 Jul-Sep | Rev Med Chir Soc Med Nat Iasi | pmid:16607740 |
Colombo C et al. | Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial. | 2005 Jul-Sep | Int. J. Biol. Markers | pmid:16240844 |
Morise A et al. | Dose effect of alpha-linolenic acid on lipid metabolism in the hamster. | 2005 Jul-Aug | Reprod. Nutr. Dev. | pmid:16045889 |
Milne GL et al. | The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. | 2005 Jan-Feb | Antioxid. Redox Signal. | pmid:15650409 |
Paschos GK et al. | Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic Acid. | 2005 Jan-Feb | Angiology | pmid:15678256 |
Boken SL et al. | Effect of grazing and fat supplementation on production and reproduction of Holstein cows. | 2005 | J. Dairy Sci. | pmid:16291617 |
Destaillats F et al. | Metabolites of conjugated isomers of alpha-linolenic acid (CLnA) in the rat. | 2005 | J. Agric. Food Chem. | pmid:15740017 |
Liu CG et al. | Preparation and characterization of nanoparticles containing trypsin based on hydrophobically modified chitosan. | 2005 | J. Agric. Food Chem. | pmid:15740066 |
Horia E and Watkins BA | Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures. | 2005 | J. Nutr. Biochem. | pmid:15741054 |
Oh K et al. | Dietary marine n-3 fatty acids in relation to risk of distal colorectal adenoma in women. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15824153 |
Grechkin AN et al. | Thermal conversions of trimethylsilyl peroxides of linoleic and linolenic acids. | 2005 | Chem. Phys. Lipids | pmid:16242681 |
Ribeiro CV et al. | Biohydrogenation of fatty acids and digestibility of fresh alfalfa or alfalfa hay plus sucrose in continuous culture. | 2005 | J. Dairy Sci. | pmid:16230707 |
Demar JC et al. | alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. | 2005 | J. Neurochem. | pmid:16092947 |
Fukushige H and Hildebrand DF | A simple and efficient system for green note compound biogenesis by use of certain lipoxygenase and hydroperoxide lyase sources. | 2005 | J. Agric. Food Chem. | pmid:16104814 |
Destaillats F et al. | Analysis of alpha-linolenic acid biohydrogenation intermediates in milk fat with emphasis on conjugated linolenic acids. | 2005 | J. Dairy Sci. | pmid:16107413 |
Celik A et al. | Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450(BM3) from Bacillus megaterium. | 2005 | Org. Biomol. Chem. | pmid:16032346 |
Liu CG et al. | Linolenic acid-modified chitosan for formation of self-assembled nanoparticles. | 2005 | J. Agric. Food Chem. | pmid:15656685 |
Goyens PL and Mensink RP | The dietary alpha-linolenic acid to linoleic acid ratio does not affect the serum lipoprotein profile in humans. | 2005 | J. Nutr. | pmid:16317123 |
Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
Kabagambe EK et al. | The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica. | 2005 | J. Nutr. | pmid:16251629 |
Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
Ganga R et al. | Effect of dietary lipids on plasma fatty acid profiles and prostaglandin and leptin production in gilthead seabream (Sparus aurata). | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:16257554 |