alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Conjunctivitis, Allergic D003233 1 associated lipids
Aging, Premature D019588 1 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Night Blindness D009755 1 associated lipids
Stomatitis, Aphthous D013281 1 associated lipids
Torsades de Pointes D016171 2 associated lipids
Sebaceous Gland Neoplasms D012626 2 associated lipids
Otorhinolaryngologic Neoplasms D010039 2 associated lipids
Spinal Cord Ischemia D020760 2 associated lipids
Mental Fatigue D005222 3 associated lipids
Depression, Postpartum D019052 3 associated lipids
Carcinogenesis D063646 3 associated lipids
Dyskinesias D020820 3 associated lipids
Amyloidosis D000686 4 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pancytopenia D010198 6 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Paraplegia D010264 8 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Retinal Degeneration D012162 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Long QT Syndrome D008133 10 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Learning Disorders D007859 11 associated lipids
Overweight D050177 11 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Deficiency Diseases D003677 12 associated lipids
Cat Diseases D002371 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Neoplasms D009369 13 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Bronchial Spasm D001986 18 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Pregnancy Complications D011248 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Tuberculosis D014376 20 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Myocardial Infarction D009203 21 associated lipids
Hypersensitivity D006967 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Birth Weight D001724 23 associated lipids
Cattle Diseases D002418 24 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Dermatitis D003872 30 associated lipids
Liver Diseases D008107 31 associated lipids
Stroke D020521 32 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Heart Failure D006333 36 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Fatty Liver D005234 48 associated lipids
Precancerous Conditions D011230 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Neuroblastoma D009447 66 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Atherosclerosis D050197 85 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Holman RT Nutritional and functional requirements for essential fatty acids. 1986 Prog. Clin. Biol. Res. pmid:2878441
Anding RH and Hwang DH Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. 1986 Lipids pmid:2879208
Bjerve KS et al. Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. 1987 Am. J. Clin. Nutr. pmid:2879436
Warden JT and Csatorday K On the mechanism of linolenic acid inhibition in Photosystem II. 1987 Biochim. Biophys. Acta pmid:2879567
Gutteridge JM The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. 1987 Biochim. Biophys. Acta pmid:2879568
Sato M et al. [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. 1986 Rinsho Shinkeigaku pmid:2879661
Morson LA and Clandinin MT Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. 1986 J. Nutr. pmid:2879899
Bjerve KS et al. [Essential linolenic fatty acid deficiency. Patients on long-term gastric tube feeding]. 1986 Tidsskr. Nor. Laegeforen. pmid:2880408
Gotoh K et al. Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. 1986 J. Biochem. pmid:2880840
Bjerve KS Alpha-linolenic acid deficiency in adult women. 1987 Nutr. Rev. pmid:2881237
Novo C et al. Altered fatty acid membrane composition modifies lymphocyte localization in vivo. 1987 Cell. Immunol. pmid:2882861
Yamamoto N et al. Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. 1987 J. Lipid Res. pmid:2883248
McDonald GB and Weidman M Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. 1987 Q J Exp Physiol pmid:2884690
Bursztyn P Does dietary linolenic acid influence blood pressure? 1987 Am. J. Clin. Nutr. pmid:2884863
pmid:28851088
Vrignaud P and Robert J Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. 1987 Biochim. Biophys. Acta pmid:2886153
Hasegawa J et al. Lipid requirement for mu opioid receptor binding. 1987 J. Neurochem. pmid:2887631
pmid:28880969
Singer P et al. Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. 1987 Prostaglandins Leukot Med pmid:2888133
Takahashi R et al. Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. 1987 J. Nutr. pmid:2888839
Coté GG and Brody S Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. 1987 Biochim. Biophys. Acta pmid:2889471
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of essential fatty acids on fatty acid composition. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2890285
Whitcomb RW et al. Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. 1988 J. Clin. Invest. pmid:2891726
Zöllner N Dietary linolenic acid in man--an overview. 1986 Prog. Lipid Res. pmid:2892211
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461
Urano S et al. Membrane-stabilizing effect of vitamin E: effect of alpha-tocopherol and its model compounds on fluidity of lecithin liposomes. 1988 Biochem. Biophys. Res. Commun. pmid:2892491
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Chander A and Fisher AB Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. 1988 Biochim. Biophys. Acta pmid:2893643
Hwang DH et al. Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. 1988 J. Nutr. pmid:2895804
pmid:28965514
Arthur JR Effects of selenium and vitamin E status on plasma creatine kinase activity in calves. 1988 J. Nutr. pmid:2897437
Astorg PO and Chevalier J Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid. 1987 Lipids pmid:2897610
Guesnet P et al. Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. 1988 Reprod Nutr Dev pmid:2897705
Koletzko B and Cunnane S Human alpha-linolenic acid deficiency. 1988 Am. J. Clin. Nutr. pmid:2897782
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795
Homayoun P et al. Alteration in fatty acid composition of adult rat brain capillaries and choroid plexus induced by a diet deficient in n-3 fatty acids: slow recovery after substitution with a nondeficient diet. 1988 J. Neurochem. pmid:2898007
Huang YS et al. Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding. 1987 Biochem. Int. pmid:2898942
Fan WX [Alpha-linolenic acid and its metabolites EPA and DHA]. 1988 Sheng Li Ke Xue Jin Zhan pmid:2901141
Garg ML et al. Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. 1988 Biochim. Biophys. Acta pmid:2901857
Yamamoto N et al. Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. 1988 J. Lipid Res. pmid:2903207
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Khokher MA and Dandona P The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin. 1988 Diabetes Res. pmid:2906578
Blasig IE et al. Effect of troxerutin and methionine on spin trapping of free oxy-radicals. 1988 Biomed. Biochim. Acta pmid:2907855
Du H et al. Extraction and the Fatty Acid Profile of Rosa acicularis Seed Oil. 2017 J Oleo Sci pmid:29129896
pmid:29232610
pmid:29311522
pmid:29407798
pmid:29459511
Jones DB et al. Glucose, insulin and platelet fatty acids following myocardial infarction: an association with infarct size. 1987 Jul-Aug Diabete Metab pmid:3315767
Furukawa M et al. Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. 1984 Biochim. Biophys. Acta pmid:6089906
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Bolton-Smith C et al. Comparative aspects of omega-3 and omega-6 polyunsaturated fatty acids in rabbits and rats: effects on platelet function, thromboxane and prostacyclin generation, tissue phospholipid fatty acids and membrane fluidity. 1984 Br J Clin Pract Suppl pmid:6091719
Osipov AN et al. [Study of radicals formed in the interaction of organic hydroperoxides with ferric ions using the spin trap method]. 1984 Jul-Aug Biofizika pmid:6091781
Golbeck JH and Warden JT Interaction of linolenic acid with bound quinone molecules in Photosystem II. Time-resolved optical and electron spin resonance studies. 1984 Biochim. Biophys. Acta pmid:6093871
Hagve TA and Christophersen BO Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. 1984 Biochim. Biophys. Acta pmid:6093889
Cocchi M et al. Effect of C 18:3 (n-3) dietary supplementation on the fatty acid composition of the rat brain. 1984 Acta Vitaminol. Enzymol. pmid:6098183
Codde JP et al. Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. 1984 J. Hypertens. pmid:6099384
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Volpe JJ and Obert KA Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. 1981 Arch. Biochem. Biophys. pmid:6118099
Renaud S and Nordøy A "Small is beautiful": alpha-linolenic acid and eicosapentaenoic acid in man. 1983 Lancet pmid:6133188
Poisson JP and Blond JP [Effect of supplementation with gamma-linolenic acid on the fatty acid composition of lipids from the liver and plasma in the diabetic rat]. 1983 Arch. Int. Physiol. Biochim. pmid:6204605
Budowski P et al. [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. 1980 Ann Nutr Aliment pmid:6254420
François M et al. [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. 1980 Ann Nutr Aliment pmid:6254422
Vergroesen AJ et al. Cardiovascular effects of linoleic acid. 1980 Prog Food Nutr Sci pmid:6256818
Cowey CB et al. Tissue distribution, uptake, and requirement for alpha-tocopherol of rainbow trout (Salmo gairdneri) fed diets with a minimal content of unsaturated fatty acids. 1981 J. Nutr. pmid:6268765
Yoshino M and Murakami K Effect of spermine on the inhibition by fatty acid on AMP deaminase reaction as a control system of the adenylate energy charge in yeast. 1981 Biochem. Biophys. Res. Commun. pmid:6272814
Dusting GJ et al. Increased conversion of arachidonic acid to vasodilator prostanoids in spontaneously hypertensive rats. 1981 Sep-Oct Clin. Exp. Pharmacol. Physiol. pmid:6276057
Torinuki W et al. Chemiluminescence of UV-irradiated linolenic acid and squalene. 1982 Tohoku J. Exp. Med. pmid:6280339
Quadt JF and ten Hoor F Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. 1981 Prog. Lipid Res. pmid:6281803
Marshall LA and Johnston PV alpha-Linolenic and linoleic acids and the immune response. 1981 Prog. Lipid Res. pmid:6281806
Scherhag R et al. Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. 1982 Prostaglandins pmid:6285420
Yoshino M and Murakami K AMP deaminase as a control system of glycolysis in yeast. Mechanism of the inhibition of glycolysis by fatty acid and citrate. 1982 J. Biol. Chem. pmid:6286666
Tinoco J Dietary requirements and functions of alpha-linolenic acid in animals. 1982 Prog. Lipid Res. pmid:6287500
Ayala S and Brenner RR Effect of polyunsaturated fatty acids of the alpha-linolenic series in the lipid composition of rat testicles during development. 1980 Acta Physiol Lat Am pmid:6287807
Bozian RC and Moussavian SN Human linolenic acid deficiency. 1982 Am. J. Clin. Nutr. pmid:6293298
Rosenthal MD and Whitehurst MC Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. 1982 J. Cell. Physiol. pmid:6294123
Yoshino M and Murakami K The regulatory role of spermine and fatty acid in the interaction of AMP deaminase with phosphofructokinase. 1982 Biochim. Biophys. Acta pmid:6295506
Rosenthal MD and Whitehurst MC Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. 1983 Biochim. Biophys. Acta pmid:6297606
Oliw EH Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. 1983 Biochem. Biophys. Res. Commun. pmid:6301473
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Sanders TA Dietary fat and platelet function. 1983 Clin. Sci. pmid:6309463
Byrne WJ Intralipid or Liposyn--comparable products? 1982 J. Pediatr. Gastroenterol. Nutr. pmid:6310073
Magrum LJ and Johnston PV Modulation of prostaglandin synthesis in rat peritoneal macrophages with omega-3 fatty acids. 1983 Lipids pmid:6312240
Marshall LA et al. Dietary alpha-linolenic acid and prostaglandin synthesis: a time course study. 1983 Am. J. Clin. Nutr. pmid:6316775
Neuringer M et al. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. 1984 J. Clin. Invest. pmid:6317716
Hansen HS and Jensen B Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation. 1983 Lipids pmid:6318006
Marshall LA and Johnston PV The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. 1983 Lipids pmid:6318008
Nicholson T and Omer SA The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. 1983 Zentralbl Veterinarmed A pmid:6318476
Gutteridge JM et al. Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals. 1983 Biochem. Biophys. Res. Commun. pmid:6320819
McCarty MF Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension. 1984 Med. Hypotheses pmid:6328233
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Watanabe T et al. Immobilization of lipases on polyethylene and application to perilla oil hydrolysis for production of alpha-linolenic acid. 1995 J. Nutr. Sci. Vitaminol. pmid:7472675
Francès H et al. Effects of dietary alpha-linolenic acid deficiency on neuromuscular and cognitive functions in mice. 1995 Life Sci. pmid:7475943
Muñoz SF et al. Protective capability of dietary Zizyphus mistol seed oil, rich in 18:3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480075
Tsutsumi T et al. Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain--modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP. 1995 Biol. Pharm. Bull. pmid:7492979
Hartman IS alpha-Linolenic acid: a preventive in secondary coronary events? 1995 Nutr. Rev. pmid:7494621
Ahn DU et al. Effects of dietary alpha-linolenic acid and strain of hen on the fatty acid composition, storage stability, and flavor characteristics of chicken eggs. 1995 Poult. Sci. pmid:7501600
Kawasaki M et al. Effect of alpha-linolenic acid on the metabolism of omega-3 and omega-6 polyunsaturated fatty acids and histamine release in RBL-2H3 cells. 1994 Biol. Pharm. Bull. pmid:7533019
Larsson-Backström C et al. Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. 1995 Shock pmid:7552772
Fujiyama-Fujiwara Y et al. Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. 1995 J. Nutr. Sci. Vitaminol. pmid:7562115