Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ivan M et al. | Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. | 2013 | Br. J. Nutr. | pmid:22850225 |
Zheng JS et al. | Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. | 2013 | BMJ | pmid:23814120 |
Almario RU and Karakas SE | Lignan content of the flaxseed influences its biological effects in healthy men and women. | 2013 | J Am Coll Nutr | pmid:23885993 |
Monge-Rojas R et al. | Changes in dietary intake and food sources of saturated and cis and trans unsaturated fatty acids in Costa Rican adolescents: 1996 versus 2006. | 2013 | Nutrition | pmid:23298971 |
Molkentin J | Applicability of organic milk indicators to the authentication of processed products. | 2013 | Food Chem | pmid:23199986 |
Ulas T et al. | Does α-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients? | 2013 | Int. J. Cardiol. | pmid:23200266 |
Zhao ML et al. | Enzymatic production of zero-trans plastic fat rich in α-linolenic acid and medium-chain fatty acids from highly hydrogenated soybean oil, Cinnamomum camphora seed oil, and perilla oil by lipozyme TL IM. | 2013 | J. Agric. Food Chem. | pmid:23350869 |
Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
Yan W et al. | Reply to manuscript IJC-D-12-04197 entitled "Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?" by MD Turgay Ulas. | 2013 | Int. J. Cardiol. | pmid:23313466 |
Yan W et al. | Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. | 2013 | Int. J. Cardiol. | pmid:23102606 |
Walker CG et al. | Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. | 2013 | Nutrition | pmid:23102888 |
Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
Perga ME et al. | Are cyanobacterial blooms trophic dead ends? | 2013 | Oecologia | pmid:23129401 |
Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
Kastner DW and Van Wagoner DR | Diet and atrial fibrillation: does α-linolenic acid, a plant derived essential fatty acid, have an impact? | 2013 | J Am Heart Assoc | pmid:23525415 |
Fretts AM et al. | Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study. | 2013 | J Am Heart Assoc | pmid:23525429 |
Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
Monteiro J et al. | Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. | 2013 | Can. J. Physiol. Pharmacol. | pmid:23746194 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Liu M et al. | Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. | 2013 | J. Lipid Res. | pmid:23740966 |
Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
Lai YH et al. | Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. | 2013 | Clin Nutr | pmid:23711994 |
Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
Sun L et al. | The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. | 2013 | Int. J. Biol. Sci. | pmid:23983614 |
Kwon TY et al. | Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. | 2013 | J. Agric. Food Chem. | pmid:23968142 |
Lund AS et al. | N-3 polyunsaturated fatty acids, body fat and inflammation. | 2013 | Obes Facts | pmid:23970146 |
Lagunas B et al. | A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). | 2013 | Phytochemistry | pmid:23928132 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
Yu X et al. | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis. | 2013 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:23896563 |
Egusa Saiga A and Nishimura T | Antioxidative properties of peptides obtained from porcine myofibrillar proteins by a protease treatment in an Fe (II)-induced aqueous lipid peroxidation system. | 2013 | Biosci. Biotechnol. Biochem. | pmid:24200778 |
Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
Afitlhile M et al. | A mutant of the Arabidopsis thaliana TOC159 gene accumulates reduced levels of linolenic acid and monogalactosyldiacylglycerol. | 2013 | Plant Physiol. Biochem. | pmid:24184455 |
Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
Warstedt K and Duchén K | Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. | 2013 | Eur J Nutr | pmid:22584414 |
Coles L et al. | A model to predict the ATP equivalents of macronutrients absorbed from food. | 2013 | Food Funct | pmid:23233079 |
Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
Shen JH et al. | Effect of α-linolenic acid on streptozotocin-induced diabetic retinopathy indices in vivo. | 2013 | Arch. Med. Res. | pmid:24120388 |
Végner L et al. | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. | 2013 | J. Med. Chem. | pmid:24088053 |
Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
Khaw KT | Dietary fats and breast cancer risk. | 2013 | BMJ | pmid:23861431 |
Ghisolfi J et al. | Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. | 2013 | Public Health Nutr | pmid:23098567 |
Katrangi W et al. | Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. | 2013 | Lipids | pmid:23440519 |
Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
Yi LT et al. | Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. | 2013 | J Ethnopharmacol | pmid:23506995 |
Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
Meijerink J et al. | N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. | 2013 | Br. J. Pharmacol. | pmid:23088259 |
Chechetkin IR et al. | Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. | 2013 | Phytochemistry | pmid:24042063 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Niculescu MD et al. | Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. | 2013 | FASEB J. | pmid:22997227 |
Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
Shin JA et al. | Preparation of recombined milk using modified butterfats containing α-linolenic acid. | 2013 | J. Food Sci. | pmid:23278855 |
Botsoglou E et al. | Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22716021 |
Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
Gladine C et al. | Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. | 2013 | J. Nutr. Biochem. | pmid:22784432 |
Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
Rahman H et al. | Development of low-linolenic acid Brassica oleracea lines through seed mutagenesis and molecular characterization of mutants. | 2013 | Theor. Appl. Genet. | pmid:23475317 |
Wei M et al. | Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. | 2013 | J Tradit Chin Med | pmid:23789212 |
Esselburn KM et al. | Intake of specific fatty acids and fat alters growth, health, and titers following vaccination in dairy calves. | 2013 | J. Dairy Sci. | pmid:23810586 |
Hanke D et al. | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24140006 |
Petrogianni M et al. | Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. | 2014 | Public Health Nutr | pmid:23249766 |
Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
Lagarde M et al. | Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. | 2014 | Biochimie | pmid:25223888 |
De Mel D and Suphioglu C | Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. | 2014 | Nutrients | pmid:25195602 |
Fretts AM et al. | Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study. | 2014 | Br. J. Nutr. | pmid:25159901 |
Villar-Tajadura MA et al. | Production of conjugated linoleic and conjugated α-linolenic acid in a reconstituted skim milk-based medium by bifidobacterial strains isolated from human breast milk. | 2014 | Biomed Res Int | pmid:25110689 |
Hoogeveen EK et al. | Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. | 2014 | Clin J Am Soc Nephrol | pmid:25104273 |
Hwang E et al. | Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. | 2014 | J Med Food | pmid:25019675 |
dos Santos AL et al. | Dietary fat composition and cardiac events in patients with type 2 diabetes. | 2014 | Atherosclerosis | pmid:25014032 |
Caligiuri SP et al. | The HYPERFlax trial for determining the anti-HYPERtensive effects of dietary flaxseed in newly diagnosed stage 1 hypertensive patients: study protocol for a randomized, double-blinded, controlled clinical trial. | 2014 | Trials | pmid:24938224 |
Baumgartner J et al. | Providing male rats deficient in iron and n-3 fatty acids with iron and alpha-linolenic acid alone affects brain serotonin and cognition differently from combined provision. | 2014 | Lipids Health Dis | pmid:24928171 |
Djoussé L et al. | Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. | 2014 | Eur J Nutr | pmid:24395612 |
Eisinger K et al. | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Exp. Mol. Pathol. | pmid:24830603 |
Ebrahimi M et al. | Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. | 2014 | Nutrients | pmid:25255382 |
Marklund M et al. | A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome. | 2014 | J. Nutr. | pmid:25080537 |
Purushothaman D et al. | Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. | 2014 | Genet. Mol. Res. | pmid:25078588 |
Hellstrand S et al. | Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. | 2014 | J. Nutr. | pmid:25008580 |
Aki T et al. | Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. | 2014 | Lipids | pmid:24174374 |
Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
Carbonera F et al. | Effect of dietary replacement of sunflower oil with perilla oil on the absolute fatty acid composition in Nile tilapia (GIFT). | 2014 | Food Chem | pmid:24262550 |
Morris JB et al. | Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. | 2014 | J Diet Suppl | pmid:25054688 |
Mariutto M et al. | Reprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato. | 2014 | Plant Mol. Biol. | pmid:24146221 |
Able JA et al. | Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. | 2014 | J Psychiatr Res | pmid:24360505 |
Zhang T et al. | High-fat diet from perilla oil induces insulin resistance despite lower serum lipids and increases hepatic fatty acid oxidation in rats. | 2014 | Lipids Health Dis | pmid:24422660 |
MartÃnez-RamÃrez HR et al. | Whole-body retention of α-linolenic acid and its apparent conversion to other n-3 PUFA in growing pigs are reduced with the duration of feeding α-linolenic acid. | 2014 | Br. J. Nutr. | pmid:24438755 |
Saliba L et al. | Effect of feeding linseed oil in diets differing in forage to concentrate ratio: 1. Production performance and milk fat content of biohydrogenation intermediates of α-linolenic acid. | 2014 | J. Dairy Res. | pmid:24433586 |
Dai XW et al. | Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. | 2014 | Atherosclerosis | pmid:24401220 |
MartÃnez-RamÃrez HR et al. | Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs. | 2014 | J. Anim. Sci. | pmid:24305874 |
Gong Z et al. | G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24222669 |
Sánchez-Reyes OB et al. | Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. | 2014 | Eur. J. Pharmacol. | pmid:24239485 |
Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
Yuan X et al. | Accumulation of eicosapolyenoic acids enhances sensitivity to abscisic acid and mitigates the effects of drought in transgenic Arabidopsis thaliana. | 2014 | J. Exp. Bot. | pmid:24609499 |
Berasategi I et al. | Reduced-fat bologna sausages with improved lipid fraction. | 2014 | J. Sci. Food Agric. | pmid:24105447 |
Dal Bosco A et al. | Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. | 2014 | Meat Sci. | pmid:24036258 |
Wennman A et al. | Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. | 2014 | Arch. Biochem. Biophys. | pmid:24857825 |
Liang CH et al. | Synthesis of doxorubicin α-linolenic acid conjugate and evaluation of its antitumor activity. | 2014 | Mol. Pharm. | pmid:24720787 |
Yang Q et al. | Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. | 2014 | BMC Complement Altern Med | pmid:25252789 |