Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bjerve KS et al. | Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. | 1992 Mar-Apr | Nutrition | pmid:1350473 |
Singer P | Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia. | 1992 Mar-Apr | Nutrition | pmid:1350474 |
Holub BJ and Celi B | Relationships of alpha-linolenic acid to platelet fatty acid composition and trans content of cholesterol-free foods. | 1992 Mar-Apr | Nutrition | pmid:1350475 |
Alsted AL and Høy CE | Fatty acid profiles of brain phospholipid subclasses of rats fed n - 3 polyunsaturated fatty acids of marine or vegetable origin. A two generation study. | 1992 | Biochim. Biophys. Acta | pmid:1350736 |
Arbuckle LD et al. | Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). | 1992 | Biochim. Biophys. Acta | pmid:1350737 |
Gibson RA et al. | Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. | 1992 | Biochim. Biophys. Acta | pmid:1351403 |
Fayard JM et al. | Dietary alpha-linolenic acid deficiency and early uterine development in female rats. | 1992 | J. Nutr. | pmid:1352346 |
Simopoulos AP et al. | Common purslane: a source of omega-3 fatty acids and antioxidants. | 1992 | J Am Coll Nutr | pmid:1354675 |
Roth HP and Kirchgessner M | [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. | 1992 | Ann. Nutr. Metab. | pmid:1354951 |
Garg ML and Clandinin MT | Alpha-linolenic acid and metabolism of cholesterol and long-chain fatty acids. | 1992 May-Jun | Nutrition | pmid:1356032 |
Boudreau MD et al. | Alpha-linolenic acid and prostaglandin synthesis. | 1992 May-Jun | Nutrition | pmid:1356033 |
Emken EA et al. | Human metabolic studies with deuterated alpha-linolenic acid. | 1992 May-Jun | Nutrition | pmid:1356034 |
Kelley DS | Alpha-linolenic acid and immune response. | 1992 May-Jun | Nutrition | pmid:1356035 |
Dick TA and Yang X | Alpha-linolenic acid metabolism in fish. | 1992 May-Jun | Nutrition | pmid:1356036 |
Sim JS et al. | Alpha-linolenic acid metabolism: the chicken and the egg. | 1992 May-Jun | Nutrition | pmid:1356037 |
Sakai K et al. | Lipid lowering effects of high linoleate and high alpha-linolenate diets in rats and mice. Consequence of long-term feedings. | 1992 | Chem. Pharm. Bull. | pmid:1358471 |
Rabinovitch-Chable H et al. | Purification of lipoxygenase and hydroperoxide dehydrase in flaxseeds: interaction between these enzymatic activities. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1359887 |
Hoffman DR and Uauy R | Essentiality of dietary omega 3 fatty acids for premature infants: plasma and red blood cell fatty acid composition. | 1992 | Lipids | pmid:1362792 |
Seppänen-Laakso T et al. | Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: effects on plasma fatty acid composition and serum cholesterol. | 1992 | Br. J. Nutr. | pmid:1362891 |
Noguchi A et al. | Effects of casein and soy-protein on alpha-linolenic acid metabolism in rats. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1363922 |
pmid:13642132 | ||||
Schempp H et al. | Antioxidative properties of Iberis amara extracts in biochemical model reactions. | 2003 | Arzneimittelforschung | pmid:13677247 |
JORDAN GL et al. | The effect of linoleic and linolenic acid, estradiol valerate and beta sitosterol upon experimentally induced hypercholesterolemia and the development of lipid changes in the aorta of dogs. | 1961 | Am. J. Med. Sci. | pmid:13790676 |
MOHRHAUER H and HOLMAN RT | EFFECT OF LINOLENIC ACID UPON THE METABOLISM OF LINOLEIC ACID. | 1963 | J. Nutr. | pmid:14061405 |
KORN ED and GREENBLATT CL | SYNTHESIS OF ALPHA-LINOLENIC ACID BY LEISHMANIA ENRIETTII. | 1963 | Science | pmid:14074842 |
pmid:14201664 | ||||
RAHM JJ and HOLMAN RT | EFFECT OF LINOLEIC ACID UPON THE METABOLISM OF LINOLENIC ACID. | 1964 | J. Nutr. | pmid:14210015 |
WARAVDEKAR VS et al. | HEPATIC CHANGES INDUCED BY AN AQUEOUS EXTRACT OF ULTRAVIOLET-IRRADIATED LINOLENIC ACID. | 1964 | Am. J. Pathol. | pmid:14234476 |
pmid:14318462 | ||||
CHENG AL et al. | The effect of fat level of the diet on general nutrition. XV. Comparison of the protective effect of linoleic acid and linolenic acid against multiple sublethal doses of x-irradiation in the rat. | 1955 | J. Nutr. | pmid:14368364 |
PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
Iacazio G | Easy access to various natural keto polyunsaturated fatty acids and their corresponding racemic alcohols. | 2003 | Chem. Phys. Lipids | pmid:14499470 |
Flaxseed oil: healthful or harmful for men? | 2003 | Harv Mens Health Watch | pmid:14505958 | |
Ainai T et al. | Efficient total synthesis of 12-oxo-PDA and OPC-8:0. | 2003 | J. Org. Chem. | pmid:14510562 |
Andoh A et al. | N-3 fatty acid-rich diet prevents early response of interleukin-6 elevation in trinitrobenzene sulfonic acid-induced enteritis. | 2003 | Int. J. Mol. Med. | pmid:14533000 |
Ozawa R | [Herbivore elicitors and plant signaling pathways involved in the production of herbivore-induced plant volatiles]. | 2003 | Tanpakushitsu Kakusan Koso | pmid:14535205 |
Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
Bavelaar FJ and Beynen AC | Severity of atherosclerosis in parrots in relation to the intake of alpha-linolenic acid. | 2003 Jul-Sep | Avian Dis. | pmid:14562883 |
Vecchini A et al. | Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. | 2004 | J. Lipid Res. | pmid:14563831 |
Bellini MJ et al. | Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-gamma-linoleic and alpha-linolenic acids in A549 cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14580370 |
Tavani A et al. | Alpha-linolenic acid and nonfatal acute myocardial infarction. | 2003 | Circulation | pmid:14581393 |
Bell MV et al. | Tissue deposition of n-3 FA pathway intermediates in the synthesis of DHA in rainbow trout (Oncorhynchus mykiss). | 2003 | Lipids | pmid:14584600 |
Lapillonne A et al. | Plausible mechanisms for effects of long-chain polyunsaturated fatty acids on growth. | 2003 | J. Pediatr. | pmid:14597909 |
Abdel-Lateff A et al. | A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp. | 2003 | Planta Med. | pmid:14598209 |
Rabinovitz S et al. | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). | 2004 | Psychoneuroendocrinology | pmid:14604595 |
Trommer H et al. | Examinations of the antioxidative properties of the topically administered drug bufexamac reveal new insights into its mechanism of action. | 2003 | J. Pharm. Pharmacol. | pmid:14607020 |
Valenzuela A et al. | Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. | 2004 | Ann. Nutr. Metab. | pmid:14639043 |
de Groot RH et al. | Alpha-linolenic acid supplementation during human pregnancy does not effect cognitive functioning. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643178 |
Salvati S et al. | Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. | 2004 | Neurochem. Int. | pmid:14643750 |
Logan AC | Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. | 2003 | Altern Med Rev | pmid:14653768 |
[Dietary management of lipid disorders. Plant oil protects hearts of diabetic patients]. | 2003 | MMW Fortschr Med | pmid:14655490 | |
Chuang SS et al. | CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. | 2004 | J. Biol. Chem. | pmid:14660610 |
Pawlosky R et al. | n-3 fatty acid metabolism in women. | 2003 | Br. J. Nutr. | pmid:14667193 |
Djoussé L et al. | Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:14668270 |
Bazinet RP et al. | Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet. | 2003 | Lipids | pmid:14669969 |
Hauswirth CB et al. | High omega-3 fatty acid content in alpine cheese: the basis for an alpine paradox. | 2004 | Circulation | pmid:14676141 |
Dunn JD et al. | Effects of flax supplementation and a combined trenbolone acetate and estradiol implant on circulating insulin-like growth factor-I and muscle insulin-like growth factor-I messenger RNA levels in beef cattle. | 2003 | J. Anim. Sci. | pmid:14677858 |
Spence JD et al. | The effect of flax seed cultivars with differing content of alpha-linolenic acid and lignans on responses to mental stress. | 2003 | J Am Coll Nutr | pmid:14684754 |
Truitt CL and Paré PW | In situ translocation of volicitin by beet armyworm larvae to maize and systemic immobility of the herbivore elicitor in planta. | 2004 | Planta | pmid:14685859 |
Fleshner N et al. | Dietary fat and prostate cancer. | 2004 | J. Urol. | pmid:14713748 |
Truitt CL et al. | A plasma membrane protein from Zea mays binds with the herbivore elicitor volicitin. | 2004 | Plant Cell | pmid:14729912 |
Yoshinaga N et al. | Specific incorporation of L-glutamine into volicitin in the regurgitant of Spodoptera litura. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14730148 |
Cabrita AR et al. | Nitrogen supplementation of corn silages. 2. Assessing rumen function using fatty acid profiles of bovine milk. | 2003 | J. Dairy Sci. | pmid:14740840 |
Mutsvangwa T et al. | Short communication: Effects of a monensin premix on milk fatty acid content during subacute ruminal acidosis in dairy cows. | 2003 | J. Dairy Sci. | pmid:14740842 |
de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
Tsuzuki T et al. | Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. | 2004 | Carcinogenesis | pmid:14963014 |
Del Castillo ML et al. | Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. | 2004 | J. Agric. Food Chem. | pmid:14969555 |
Agostoni C | The difficult balance between dietary polyunsaturated fatty acids. | 2003 | Acta Paediatr. | pmid:14971782 |
Thiombiano-Coulibaly N et al. | Seasonal and environmental effects on breast milk fatty acids in Burkina Faso and the need to improve the omega 3 PUFA content. | 2003 | Acta Paediatr. | pmid:14971787 |
Bloedon LT and Szapary PO | Flaxseed and cardiovascular risk. | 2004 | Nutr. Rev. | pmid:14995053 |
Walters D et al. | Antifungal activities of four fatty acids against plant pathogenic fungi. | 2004 | Mycopathologia | pmid:15008350 |
Lissak A et al. | Oxidative stress indices in seminal plasma, as measured by the thermochemiluminescence assay, correlate with sperm parameters. | 2004 | Fertil. Steril. | pmid:15019811 |
Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
Colazo MG et al. | Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed. | 2004 | Theriogenology | pmid:15036999 |
Ros E et al. | A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. | 2004 | Circulation | pmid:15037535 |
Brouwer IA et al. | Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. | 2004 | J. Nutr. | pmid:15051847 |
Maffei M et al. | Effects of feeding Spodoptera littoralis on lima bean leaves. I. Membrane potentials, intracellular calcium variations, oral secretions, and regurgitate components. | 2004 | Plant Physiol. | pmid:15051862 |
Burdge G | Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. | 2004 | Curr Opin Clin Nutr Metab Care | pmid:15075703 |
Padilla S et al. | Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. | 2004 | J. Biol. Chem. | pmid:15078893 |
Nielsen GS et al. | Formation of volatile compounds in model experiments with crude leek (Allium ampeloprasum Var. Lancelot) enzyme extract and linoleic acid or linolenic acid. | 2004 | J. Agric. Food Chem. | pmid:15080639 |
Speake BK et al. | Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. | 2004 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:15085383 |
Kodas E et al. | Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. | 2004 | J. Neurochem. | pmid:15086526 |
Cardoso CR et al. | Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. | 2004 Mar-Apr | Wound Repair Regen | pmid:15086775 |
Ipatova OM et al. | [Biological activity of linseed oil as the source of omega-3 alpha-linolenic acid]. | 2004 Jan-Feb | Biomed Khim | pmid:15108624 |
Frey M et al. | Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects. | 2004 | Phytochemistry | pmid:15110684 |
Torstensen BE and Stubhaug I | Beta-oxidation of 18:3n-3 in Atlantic salmon (Salmo salar L.) hepatocytes treated with different fatty acids. | 2004 | Lipids | pmid:15134142 |
Delmonte P et al. | Synthesis, isolation, and GC analysis of all the 6,8- to 13,15-cis/trans conjugated linoleic acid isomers. | 2004 | Lipids | pmid:15134147 |
Rallidis LS et al. | The effect of diet enriched with alpha-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients. | 2004 | Atherosclerosis | pmid:15135261 |
Menendez JA et al. | Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. | 2004 | Int. J. Oncol. | pmid:15138577 |
Astorg P | Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. | 2004 | Cancer Causes Control | pmid:15141138 |
Bertrandt J et al. | Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. | 2004 | Nahrung | pmid:15146965 |
Nelson TL and Hickey MS | Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males. | 2004 | Cytokine | pmid:15157896 |
Jia Q et al. | Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. | 2004 | J. Nutr. | pmid:15173396 |
Fraser TC et al. | Expression of the Isochrysis C18-delta9 polyunsaturated fatty acid specific elongase component alters Arabidopsis glycerolipid profiles. | 2004 | Plant Physiol. | pmid:15173563 |
Moriguchi T et al. | Effects of an n-3-deficient diet on brain, retina, and liver fatty acyl composition in artificially reared rats. | 2004 | J. Lipid Res. | pmid:15175358 |
De Moraes CM and Mescher MC | Biochemical crypsis in the avoidance of natural enemies by an insect herbivore. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15184664 |
Wijendran V and Hayes KC | Dietary n-6 and n-3 fatty acid balance and cardiovascular health. | 2004 | Annu. Rev. Nutr. | pmid:15189133 |
Nguyen LQ et al. | Influence of dietary linseed, fish and coconut oil on growth performance of growing pigs kept on small holdings in central Vietnam. | 2004 | J Anim Physiol Anim Nutr (Berl) | pmid:15189425 |
Zhang HY et al. | Isolation and functional assessment of a tomato proteinase inhibitor II gene. | 2004 | Plant Physiol. Biochem. | pmid:15191748 |
Onyango AN et al. | The rapid oxidative degradation of a phosphatidylcholine bearing an oxidatively modified acyl chain with a 2,4-dienal terminal. | 2004 | Chem. Phys. Lipids | pmid:15210367 |