alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Hearing Loss, High-Frequency D006316 1 associated lipids
Aging, Premature D019588 1 associated lipids
Night Blindness D009755 1 associated lipids
Stomatitis, Aphthous D013281 1 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Sebaceous Gland Neoplasms D012626 2 associated lipids
Otorhinolaryngologic Neoplasms D010039 2 associated lipids
Spinal Cord Ischemia D020760 2 associated lipids
Torsades de Pointes D016171 2 associated lipids
Dyskinesias D020820 3 associated lipids
Mental Fatigue D005222 3 associated lipids
Carcinogenesis D063646 3 associated lipids
Depression, Postpartum D019052 3 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Amyloidosis D000686 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pancytopenia D010198 6 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Paraplegia D010264 8 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Retinal Degeneration D012162 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Long QT Syndrome D008133 10 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Overweight D050177 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Learning Disorders D007859 11 associated lipids
Deficiency Diseases D003677 12 associated lipids
Cat Diseases D002371 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Neoplasms D009369 13 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Bronchial Spasm D001986 18 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Pregnancy Complications D011248 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Tuberculosis D014376 20 associated lipids
Myocardial Infarction D009203 21 associated lipids
Hypersensitivity D006967 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Birth Weight D001724 23 associated lipids
Breast Neoplasms D001943 24 associated lipids
Cattle Diseases D002418 24 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Dermatitis D003872 30 associated lipids
Liver Diseases D008107 31 associated lipids
Stroke D020521 32 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Epilepsy D004827 35 associated lipids
Heart Failure D006333 36 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Neuroblastoma D009447 66 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
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Kelley DS Alpha-linolenic acid and immune response. 1992 May-Jun Nutrition pmid:1356035
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Cunnane SC et al. Low zinc intake increases apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. 1993 Mar-Apr Can. J. Physiol. Pharmacol. pmid:8104673
Jiang Z and Sim JS Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. 1993 Nov-Dec Nutrition pmid:7906572
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Yuasa H et al. Gastric emptying-limited oral absorption of alpha-linolenic acid administered as a milk fat-globule membrane (MFGM) emulsion in rats. 1994 Biol. Pharm. Bull. pmid:7841950
Moore SA Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid. 1994 World Rev Nutr Diet pmid:7871814
McKeigue P Diets for secondary prevention of coronary heart disease: can linolenic acid substitute for oily fish? 1994 Lancet pmid:7911171
de Lorgeril M et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. 1994 Lancet pmid:7911176
Yehuda S et al. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. 1994 Eur. J. Pharmacol. pmid:7911428
Chen Q and Nilsson A Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. 1994 J. Lipid Res. pmid:7911819
Caffieri S et al. Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. 1994 J. Photochem. Photobiol. B, Biol. pmid:7912265
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Crastes de Paulet A et al. [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. 1994 Bull. Acad. Natl. Med. pmid:7913655
Huang YS et al. Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. 1994 Biochem. Med. Metab. Biol. pmid:7910749
Mantzioris E et al. Mediterranean diet. 1994 Lancet pmid:7914327
Yamaguchi Y et al. Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. 1994 Magnes Res pmid:7914418
Bougnoux P et al. alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. 1994 Br. J. Cancer pmid:7914425
Cunnane SC and McIntosh D alpha-Linolenic acid and reduction of cardiac deaths. 1994 Lancet pmid:7914995
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Winters BL et al. Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. 1994 J. Nutr. pmid:7916377
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Ackman RG alpha-Linolenic acid in human adipose tissue. 1994 Lipids pmid:7916440
Mlakar A and Spiteller G Reinvestigation of lipid peroxidation of linolenic acid. 1994 Biochim. Biophys. Acta pmid:7918602
Yuasa H et al. Evaluation of milk fat-globule membrane (MFGM) emulsion for oral administration: absorption of alpha-linolenic acid in rats and the effect of emulsion droplet size. 1994 Biol. Pharm. Bull. pmid:7920450
Kawashima Y et al. Modulation by dietary oils and clofibric acid of arachidonic acid content in phosphatidylcholine in liver and kidney of rat: effects on prostaglandin formation in kidney. 1994 Biochim. Biophys. Acta pmid:8280769
Saito M Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. 1994 Ann. Nutr. Metab. pmid:7702359
Lawrence JF et al. An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. 1994 Nat. Toxins pmid:7866668
Mantzioris E et al. Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. 1994 Am. J. Clin. Nutr. pmid:7910999
Anderson GJ and Connor WE Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. 1994 Am. J. Clin. Nutr. pmid:7911000
Uauy-Dagach R et al. Essential fatty acid metabolism and requirements for LBW infants. 1994 Acta Paediatr Suppl pmid:7734797
Stillwell W et al. Cholesterol condensation of alpha-linolenic and gamma-linolenic acid-containing phosphatidylcholine monolayers and bilayers. 1994 Biochim. Biophys. Acta pmid:7918592
Richieri GV et al. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. 1994 J. Biol. Chem. pmid:7929039
Yang X and Dick TA Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). 1994 J. Nutr. pmid:7913126
Emken EA et al. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. 1994 Biochim. Biophys. Acta pmid:7914092
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Ulmann L et al. Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. 1994 Biochim. Biophys. Acta pmid:7915142
Watanabe S et al. A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. 1994 J. Nutr. pmid:7916376
del Carmen Boyano-Adánez M et al. Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. 1994 Biochim. Biophys. Acta pmid:7918608
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Ikeda I et al. alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. 1994 J. Nutr. pmid:7931698
Regdel D et al. On the reaction specificity of the lipoxygenase from tomato fruits. 1994 Biochim. Biophys. Acta pmid:7905748
Lockwood K et al. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. 1994 Biochem. Biophys. Res. Commun. pmid:7908519
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Narisawa T et al. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. 1994 Cancer pmid:7908858
Mibu H et al. A study on lipid peroxide-induced lens damage in vitro. 1994 Exp. Eye Res. pmid:7908884
Laethem RM et al. Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. 1994 Biochim. Biophys. Acta pmid:7910485
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Gibson RA et al. Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. 1994 J. Pediatr. pmid:7965453
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Delion S et al. Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. 1994 J. Nutr. pmid:16856329
Pawlosky R et al. Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. 1994 J. Lipid Res. pmid:7868981
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
Goré J et al. Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. 1994 Lipids pmid:7861937
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Sacks GS et al. Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. 1994 May-Jun JPEN J Parenter Enteral Nutr pmid:7914941
Brown RO et al. Comparison of specialized and standard enteral formulas in trauma patients. 1994 May-Jun Pharmacotherapy pmid:7937272
Ghafoorunissa Dietary lipids and heart disease--the Indian context. 1994 Nov-Dec Natl Med J India pmid:7841878
Kojima S et al. Antioxidative activity of benzylideneascorbate and its effect on adriamycin-induced cardiotoxicity. 1994 Sep-Oct Anticancer Res. pmid:7847820
Kardinaal AF et al. Relations between antioxidant vitamins in adipose tissue, plasma, and diet. 1995 Am. J. Epidemiol. pmid:7879788
Sheaff RC et al. Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. 1995 J. Lipid Res. pmid:7658170
Guo W and Hamilton JA Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study. 1995 Biophys. J. pmid:7647242
Smuts CM et al. The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7708822
Saradhi PP et al. Proline accumulates in plants exposed to UV radiation and protects them against UV induced peroxidation. 1995 Biochem. Biophys. Res. Commun. pmid:7726821
Nordström DC et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. 1995 Rheumatol. Int. pmid:7597378
Ferrier LK et al. alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. 1995 Am. J. Clin. Nutr. pmid:7598070
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