Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chen Q and Nilsson A | Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. | 1994 | J. Lipid Res. | pmid:7911819 |
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Bougnoux P et al. | alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. | 1994 | Br. J. Cancer | pmid:7914425 |
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Winters BL et al. | Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. | 1994 | J. Nutr. | pmid:7916377 |
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Ackman RG | alpha-Linolenic acid in human adipose tissue. | 1994 | Lipids | pmid:7916440 |
Mlakar A and Spiteller G | Reinvestigation of lipid peroxidation of linolenic acid. | 1994 | Biochim. Biophys. Acta | pmid:7918602 |
Yuasa H et al. | Evaluation of milk fat-globule membrane (MFGM) emulsion for oral administration: absorption of alpha-linolenic acid in rats and the effect of emulsion droplet size. | 1994 | Biol. Pharm. Bull. | pmid:7920450 |
Kawashima Y et al. | Modulation by dietary oils and clofibric acid of arachidonic acid content in phosphatidylcholine in liver and kidney of rat: effects on prostaglandin formation in kidney. | 1994 | Biochim. Biophys. Acta | pmid:8280769 |
Saito M | Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. | 1994 | Ann. Nutr. Metab. | pmid:7702359 |
Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
Mantzioris E et al. | Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. | 1994 | Am. J. Clin. Nutr. | pmid:7910999 |
Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
Uauy-Dagach R et al. | Essential fatty acid metabolism and requirements for LBW infants. | 1994 | Acta Paediatr Suppl | pmid:7734797 |
Stillwell W et al. | Cholesterol condensation of alpha-linolenic and gamma-linolenic acid-containing phosphatidylcholine monolayers and bilayers. | 1994 | Biochim. Biophys. Acta | pmid:7918592 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
Emken EA et al. | Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. | 1994 | Biochim. Biophys. Acta | pmid:7914092 |
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Narisawa T et al. | Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | 1994 | Cancer | pmid:7908858 |
Mibu H et al. | A study on lipid peroxide-induced lens damage in vitro. | 1994 | Exp. Eye Res. | pmid:7908884 |
Laethem RM et al. | Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. | 1994 | Biochim. Biophys. Acta | pmid:7910485 |
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Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
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Delion S et al. | Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. | 1994 | J. Nutr. | pmid:16856329 |
Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
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Sacks GS et al. | Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. | 1994 May-Jun | JPEN J Parenter Enteral Nutr | pmid:7914941 |
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Ghafoorunissa | Dietary lipids and heart disease--the Indian context. | 1994 Nov-Dec | Natl Med J India | pmid:7841878 |
Kojima S et al. | Antioxidative activity of benzylideneascorbate and its effect on adriamycin-induced cardiotoxicity. | 1994 Sep-Oct | Anticancer Res. | pmid:7847820 |
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Sheaff RC et al. | Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. | 1995 | J. Lipid Res. | pmid:7658170 |
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Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
Saradhi PP et al. | Proline accumulates in plants exposed to UV radiation and protects them against UV induced peroxidation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7726821 |
Nordström DC et al. | Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. | 1995 | Rheumatol. Int. | pmid:7597378 |
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