alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vinggaard AM et al. | Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. | 1997 | Cell. Signal. | pmid:9113419 |
| Oh-hashi K et al. | Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. | 1997 | Biol. Pharm. Bull. | pmid:9084876 |
| Tranchant T et al. | Mechanisms and kinetics of alpha-linolenic acid uptake in Caco-2 clone TC7. | 1997 | Biochim. Biophys. Acta | pmid:9106494 |
| Yoshida S et al. | Synaptic vesicle ultrastructural changes in the rat hippocampus induced by a combination of alpha-linolenate deficiency and a learning task. | 1997 | J. Neurochem. | pmid:9048773 |
| Sugihara N et al. | Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid. | 1997 | Toxicology | pmid:9160106 |
| Kokura S et al. | Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. | 1997 | Cancer Res. | pmid:9187121 |
| Wagner W and Nootbaar-Wagner U | Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. | 1997 | Cephalalgia | pmid:9137851 |
| Spitzer V et al. | Structure analysis of an allene-containing estolide tetraester triglyceride in the seed oil of Sebastiana commersoniana (Euphorbiaceae). | 1997 | Lipids | pmid:9168462 |
| Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
| Parmentier HK et al. | Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. | 1997 | Poult. Sci. | pmid:9251147 |
| Howlett NG and Avery SV | Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. | 1997 | Appl. Environ. Microbiol. | pmid:9251184 |
| Harvei S et al. | Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. | 1997 | Int. J. Cancer | pmid:9178806 |
| Cui K et al. | [Analysis of triacylglycerol composition of perilla oil by combination of non-aqueous reversed-phase high performance liquid chromatography with gas chromatography]. | 1997 | Se Pu | pmid:15739324 |
| Yehuda S et al. | Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. | 1997 | Eur. J. Pharmacol. | pmid:9203563 |
| Hussey HJ and Tisdale MJ | Mechanism of the anti-tumour effect of 2,3,5-trimethyl-6-(3-pyridylmethyl) 1,4-benzoquinone (CV-6504). | 1997 | Br. J. Cancer | pmid:9062405 |
| Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
| Das I et al. | Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. | 1997 | Biochem. Soc. Trans. | pmid:9056997 |
| van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
| Koga T et al. | Linoleic and alpha-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats. | 1997 | Br. J. Nutr. | pmid:9155511 |
| Billeaud C et al. | Effects of preterm infant formula supplementation with alpha-linolenic acid with a linoleate/alpha-linolenate ratio of 6: a multicentric study. | 1997 | Eur J Clin Nutr | pmid:11248877 |
| Hisha H et al. | Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to. | 1997 | Blood | pmid:9242532 |
| Kim KS et al. | Dietary alpha-linolenic acid increases the biosynthesis of the choline glycerophospholipids from [14C]CDPcholine in rat liver and kidney but not in brain. | 1997 | Neurochem. Res. | pmid:9342734 |
| Lanson M et al. | Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. | 1997 | J Lipid Mediat Cell Signal | pmid:9246607 |
| Lu Z et al. | Low linolenate and commercial soybean oils diminish serum HDL cholesterol in young free-living adult females. | 1997 | J Am Coll Nutr | pmid:9430084 |
| Schimke I et al. | Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431820 |
| Carlson SE | Functional effects of increasing omega-3 fatty acid intake. | 1997 | J. Pediatr. | pmid:9290597 |
| Jensen CL et al. | Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. | 1997 | J. Pediatr. | pmid:9290604 |
| Lorenzini A et al. | Age-related changes in essential fatty acid metabolism in cultured rat heart myocytes. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9250697 |
| Huang MZ et al. | Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats. | 1997 | Lipids | pmid:9252963 |
| Jeffery NM et al. | Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. | 1997 | Br. J. Nutr. | pmid:9175999 |
| Sugiyama K et al. | Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. | 1997 | Lipids | pmid:9270978 |
| Tomioka H et al. | Effector molecules of the host defence mechanism against Mycobacterium avium complex: the evidence showing that reactive oxygen intermediates, reactive nitrogen intermediates, and free fatty acids each alone are not decisive in expression of macrophage antimicrobial activity against the parasites. | 1997 | Clin. Exp. Immunol. | pmid:9276519 |
| Okuno M et al. | Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. | 1997 | J. Nutr. | pmid:9278555 |
| Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
| Kelso KA et al. | Effects of dietary supplementation with alpha-linolenic acid on the phospholipid fatty acid composition and quality of spermatozoa in cockerel from 24 to 72 weeks of age. | 1997 | J. Reprod. Fertil. | pmid:9227357 |
| Ratnayake WM et al. | Essential fatty acids and their trans geometrical isomers in powdered and liquid infant formulas sold in Canada. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9327370 |
| Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
| Sravan Kumar G and Das UN | Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150374 |
| Anthony FA et al. | Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. | 1997 Feb-Apr | Photodermatol Photoimmunol Photomed | pmid:9361122 |
| Smith GM and Isopenko A | Effect of doses of protected polyunsaturated fatty acids on indicators of selenium status of sheep. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160431 |
| Gatchalian-Yee M et al. | Soybean protein lowers serum cholesterol levels in hamsters: effect of debittered undigested fraction. | 1997 Jul-Aug | Nutrition | pmid:9263255 |
| Hall JA et al. | Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. | 1997 Jul-Aug | J. Vet. Intern. Med. | pmid:9298479 |
| Shi X et al. | Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. | 1997 Sep-Oct | Ann. Clin. Lab. Sci. | pmid:9303176 |
| Yamada N et al. | Changes in platelet aggregation and lipid metabolism in rats given dietary lipids containing different n-3 polyunsaturated fatty acids. | 1998 | J. Nutr. Sci. Vitaminol. | pmid:9675708 |
| Colquhoun A | Induction of apoptosis by polyunsaturated fatty acids and its relationship to fatty acid inhibition of carnitine palmitoyltransferase I activity in Hep2 cells. | 1998 | Biochem. Mol. Biol. Int. | pmid:9678254 |
| Schwab US et al. | The effect of quality and amount of dietary fat on the susceptibility of low density lipoprotein to oxidation in subjects with impaired glucose tolerance. | 1998 | Eur J Clin Nutr | pmid:9683400 |
| Menard CR et al. | Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. | 1998 | J. Neurochem. | pmid:9798942 |
| Giovannini M et al. | The role of dietary polyunsaturated fatty acids during the first 2 years of life. | 1998 | Early Hum. Dev. | pmid:10102658 |
| Ikeda I et al. | Effects of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and beta-oxidation in rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9614698 |
| Prasad K et al. | Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. | 1998 | Atherosclerosis | pmid:9543108 |
| Edwards R et al. | Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients. | 1998 | J Affect Disord | pmid:9543204 |
| Zimmer L et al. | Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. | 1998 | Neurosci. Lett. | pmid:9502233 |
| Bretillon L et al. | Oxidative metabolism of [1-14C] mono-trans isomers of linoleic and alpha-linolenic acids in the rat. | 1998 | Biochim. Biophys. Acta | pmid:9507133 |
| Pähkla R et al. | Comparison of the antioxidant activity of melatonin and pinoline in vitro. | 1998 | J. Pineal Res. | pmid:9510434 |
| Sakamoto T et al. | Alteration of low-temperature susceptibility of the cyanobacterium Synechococcus sp. PCC 7002 by genetic manipulation of membrane lipid unsaturation. | 1998 | Arch. Microbiol. | pmid:9396831 |
| Kis M et al. | Light-induced expression of fatty acid desaturase genes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9539715 |
| Freiberger CE et al. | Nutrient content of the edible leaves of seven wild plants from Niger. | 1998 | Plant Foods Hum Nutr | pmid:10890758 |
| Hamberg M | A pathway for biosynthesis of divinyl ether fatty acids in green leaves. | 1998 | Lipids | pmid:9870900 |
| Tranchant T et al. | Long-term supplementation of culture medium with essential fatty acids alters alpha-linolenic acid uptake in Caco-2 clone TC7. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9923400 |
| Belzung C et al. | Alpha-linolenic acid deficiency modifies distractibility but not anxiety and locomotion in rats during aging. | 1998 | J. Nutr. | pmid:9732316 |
| Jayatilleke A and Shaw S | Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury. | 1998 | Alcohol | pmid:9665313 |
| Chavali SR et al. | Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610840 |
| Iritani N et al. | Lipogenic enzyme gene expression is quickly suppressed in rats by a small amount of exogenous polyunsaturated fatty acids. | 1998 | J. Nutr. | pmid:9614155 |
| De Stefani E et al. | Essential fatty acids and breast cancer: a case-control study in Uruguay. | 1998 | Int. J. Cancer | pmid:9590123 |
| Peterson LD et al. | Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. | 1998 | Life Sci. | pmid:9627080 |
| Okuno M et al. | Suppressive effect of low amounts of safflower and perilla oils on diethylnitrosamine-induced hepatocarcinogenesis in male F344 rats. | 1998 | Nutr Cancer | pmid:9631489 |
| Suzuki H et al. | Long-term effect of a trace amount of tea catechins with perilla oil on the plasma lipids in mice. | 1998 | Int J Vitam Nutr Res | pmid:9706503 |
| Howe PR | Omega 3 fatty acids--an Australian perspective. | 1998 | World Rev Nutr Diet | pmid:9648518 |
| Yu G et al. | Fatty acid composition in colostrum and mature milk from non-atopic and atopic mothers during the first 6 months of lactation. | 1998 | Acta Paediatr. | pmid:9722244 |
| Gerster H | Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)? | 1998 | Int J Vitam Nutr Res | pmid:9637947 |
| Weisinger HS et al. | Effect of diet on the rate of depletion of n-3 fatty acids in the retina of the guinea pig. | 1998 | J. Lipid Res. | pmid:9643359 |
| Vartak S et al. | Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. | 1998 | Br. J. Cancer | pmid:9635836 |
| Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
| Dokko RC et al. | Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. | 1998 | Int. J. Biochem. Cell Biol. | pmid:9597754 |
| Kemp B et al. | Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. | 1998 | Theriogenology | pmid:10732036 |
| Pang D et al. | Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. | 1998 | Br. J. Nutr. | pmid:9828757 |
| Parchmann S and Mueller MJ | Evidence for the formation of dinor isoprostanes E1 from alpha-linolenic acid in plants. | 1998 | J. Biol. Chem. | pmid:9830005 |
| Ihara M et al. | Comparative effects of short- and long-term feeding of safflower oil and perilla oil on lipid metabolism in rats. | 1998 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9972297 |
| Furuno K et al. | Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes. | 1998 | Pharmacol. Toxicol. | pmid:9820879 |
| Bretillon L et al. | Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. | 1998 | J. Lipid Res. | pmid:9799809 |
| Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
| Yehuda S et al. | Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. | 1998 | Neurochem. Res. | pmid:9566600 |
| Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
| Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
| Gu JY et al. | Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9836427 |
| Rao MS et al. | Yield, protein, and oil quality of soybean genotypes selected for tofu production. | 1998 | Plant Foods Hum Nutr | pmid:9950085 |
| Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
| Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1999 | Lipids | pmid:10419181 |
| Su HM et al. | Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. | 1999 | Lipids | pmid:10419199 |
| Abedin L et al. | The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. | 1999 | Lipids | pmid:10380119 |
| Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
| Tan X et al. | [Supercritical-CO2 fluid extraction of fatty oils from Perilla frutescens seeds and pharmacological study]. | 1999 | Zhong Yao Cai | pmid:12571915 |
| Birch DG | Retinal degeneration in retinitis pigmentosa and neuronal ceroid lipofuscinosis: An overview. | 1999 | Mol. Genet. Metab. | pmid:10191129 |
| Leaf A | Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. | 1999 | Circulation | pmid:9989956 |
| Weisinger HS et al. | Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:9950590 |
| Gibson RA | Long-chain polyunsaturated fatty acids and infant development. | 1999 | Lancet | pmid:10622289 |
| Oriani G et al. | Effects of intramuscular injection of alpha-tocopheryl acetate on fatty acid profile in lamb liver. | 1999 | Int J Vitam Nutr Res | pmid:10642895 |
| de Deckere EA et al. | Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. | 1999 | Br. J. Nutr. | pmid:10655980 |
| Umezawa M et al. | High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. | 1999 | J. Nutr. | pmid:10024623 |
| Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |