alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ivan M et al. | Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. | 2013 | Br. J. Nutr. | pmid:22850225 |
| Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
| Fretts AM et al. | Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study. | 2014 | Br. J. Nutr. | pmid:25159901 |
| Burak C et al. | Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial. | 2017 | Br. J. Nutr. | pmid:28366181 |
| Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
| Burdge GC et al. | Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*. | 2002 | Br. J. Nutr. | pmid:12323085 |
| Burdge GC and Wootton SA | Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. | 2002 | Br. J. Nutr. | pmid:12323090 |
| Sanderson P et al. | UK Food Standards Agency alpha-linolenic acid workshop report. | 2002 | Br. J. Nutr. | pmid:12425738 |
| Arab K et al. | Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. | 2006 | Br. J. Nutr. | pmid:17092368 |
| Fuentes F et al. | Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. | 2008 | Br. J. Nutr. | pmid:18275619 |
| Wallace FA et al. | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. | 2003 | Br. J. Nutr. | pmid:12720588 |
| Pawlosky R et al. | n-3 fatty acid metabolism in women. | 2003 | Br. J. Nutr. | pmid:14667193 |
| Chen ZY et al. | Accumulation of polyunsaturates is decreased by weight-cycling: whole-body analysis in young, growing rats. | 1996 | Br. J. Nutr. | pmid:8672410 |
| Pang D et al. | Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. | 1998 | Br. J. Nutr. | pmid:9828757 |
| Tyagi A et al. | Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. | 2012 | Br. J. Nutr. | pmid:22243775 |
| MartÃnez-RamÃrez HR et al. | Whole-body retention of α-linolenic acid and its apparent conversion to other n-3 PUFA in growing pigs are reduced with the duration of feeding α-linolenic acid. | 2014 | Br. J. Nutr. | pmid:24438755 |
| Sabaté J et al. | Does regular walnut consumption lead to weight gain? | 2005 | Br. J. Nutr. | pmid:16277792 |
| Burdge GC et al. | Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. | 2003 | Br. J. Nutr. | pmid:12908891 |
| Paschos GK et al. | Background diet influences the anti-inflammatory effect of alpha-linolenic acid in dyslipidaemic subjects. | 2004 | Br. J. Nutr. | pmid:15522134 |
| Harbige LS et al. | Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. | 1995 | Br. J. Nutr. | pmid:8541276 |
| Diwakar BT et al. | Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. | 2011 | Br. J. Nutr. | pmid:21521541 |
| Huang F et al. | EPA inhibits the inhibitor of κBα (IκBα)/NF-κB/muscle RING finger 1 pathway in C2C12 myotubes in a PPARγ-dependent manner. | 2011 | Br. J. Nutr. | pmid:20955633 |
| Nwaru BI et al. | Maternal intake of fatty acids during pregnancy and allergies in the offspring. | 2012 | Br. J. Nutr. | pmid:22067943 |
| Myhrstad MC et al. | Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. | 2011 | Br. J. Nutr. | pmid:21736782 |
| Bowen RA and Clandinin MT | Maternal dietary 22 : 6n-3 is more effective than 18 : 3n-3 in increasing the 22 : 6n-3 content in phospholipids of glial cells from neonatal rat brain. | 2005 | Br. J. Nutr. | pmid:15975158 |
| Brinkman MT et al. | Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study. | 2011 | Br. J. Nutr. | pmid:21736846 |
| Gopinath B et al. | Consumption of long-chain n-3 PUFA, α-linolenic acid and fish is associated with the prevalence of chronic kidney disease. | 2011 | Br. J. Nutr. | pmid:21255476 |
| Arshad A et al. | Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. | 2011 | Br. J. Nutr. | pmid:21745426 |
| Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
| Yang L et al. | Alpha-linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters. | 2005 | Br. J. Nutr. | pmid:15946404 |
| Takahashi Y and Ide T | Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. | 2000 | Br. J. Nutr. | pmid:11029968 |
| Seppänen-Laakso T et al. | Replacement of butter on bread by rapeseed oil and rapeseed oil-containing margarine: effects on plasma fatty acid composition and serum cholesterol. | 1992 | Br. J. Nutr. | pmid:1362891 |
| Wan ZX et al. | Lipid content and fatty acids composition of mature human milk in rural North China. | 2010 | Br. J. Nutr. | pmid:19825220 |
| Gerber M | Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. | 2012 | Br. J. Nutr. | pmid:22591896 |
| Sanjurjo P et al. | Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. | 2006 | Br. J. Nutr. | pmid:16441930 |
| Matthews KR et al. | Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues. | 2000 | Br. J. Nutr. | pmid:10911772 |
| Meijerink J et al. | N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. | 2013 | Br. J. Pharmacol. | pmid:23088259 |
| Botsoglou E et al. | Effect of supplementation of the laying hen diet with olive leaves (Olea europea L.) on lipid oxidation and fatty acid profile of α-linolenic acid enriched eggs during storage. | 2012 | Br. Poult. Sci. | pmid:23130586 |
| Parmentier HK et al. | Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. | 2002 | Br. Poult. Sci. | pmid:12365510 |
| Dänicke S et al. | Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. | 1997 | Br. Poult. Sci. | pmid:9511000 |
| Antruejo A et al. | Omega-3 enriched egg production: the effect of α -linolenic ω -3 fatty acid sources on laying hen performance and yolk lipid content and fatty acid composition. | 2011 | Br. Poult. Sci. | pmid:22221241 |
| Gonzalez-Esquerra R and Leeson S | Effects of menhaden oil and flaxseed in broiler diets on sensory quality and lipid composition of poultry meat. | 2000 | Br. Poult. Sci. | pmid:11128390 |
| Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
| Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
| Rao GN et al. | Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. | 2000 | Breast Cancer Res. Treat. | pmid:11200779 |
| Thiébaut AC et al. | [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. | 2005 | Bull Cancer | pmid:16123005 |
| Astorg P | [Dietary fatty acids and colorectal and prostate cancers: epidemiological studies]. | 2005 | Bull Cancer | pmid:16123006 |
| Bougnoux P and Menanteau J | [Dietary fatty acids and experimental carcinogenesis]. | 2005 | Bull Cancer | pmid:16123007 |
| Ohta S et al. | Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. | 1994 | Bull Environ Contam Toxicol | pmid:7910498 |
| Crastes de Paulet A et al. | [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. | 1994 | Bull. Acad. Natl. Med. | pmid:7913655 |
| Bourre JM | [Nature, origin and role of fatty acids of the nervous system: an essential fatty acid, an alpha-linolenic acid, changing the structure and the cerebral function]. | 1989 | Bull. Acad. Natl. Med. | pmid:2576722 |
| Piconneaux A et al. | [Identification of an atypical polyunsaturated fatty acid present in the liver of rats after the ingestion of heated linseed oil]. | 1985 | C. R. Acad. Sci. III, Sci. Vie | pmid:2859918 |
| Cherif A et al. | Phytosterols, unsaturated fatty acid composition and accumulation in the almond kernel during harvesting period: importance for development regulation. | 2009 | C. R. Biol. | pmid:19931844 |
| Sebei K et al. | Evolution of phosphoenolpyruvate carboxylase activity and lipid content during seed maturation of two spring rapeseed cultivars (Brassica napus L.). | 2006 | C. R. Biol. | pmid:16945838 |
| Fournier J et al. | [Lipid peroxidation in the presence of inorganic compounds. Relation to oxidative stress mechanisms]. | 1995 | C. R. Seances Soc. Biol. Fil. | pmid:8521091 |
| Oulhaj H et al. | [Utilization of linoleate and alpha-linolenate in peritubular cells and Sertoli cells in culture]. | 1994 | C. R. Seances Soc. Biol. Fil. | pmid:7834508 |
| Rodriguez-Leyva D et al. | The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. | 2010 | Can J Cardiol | pmid:21076723 |
| Das UN | Antibiotic-like action of essential fatty acids. | 1985 | Can Med Assoc J | pmid:2860965 |
| Scorolli L et al. | [Photodynamic therapy for age related macular degeneration with and without antioxidants]. | 2002 | Can. J. Ophthalmol. | pmid:12518724 |
| Levy R and Herzberg GR | Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588486 |
| Cunnane SC et al. | Low zinc intake increases apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1993 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:8104673 |
| Tranchant T et al. | Long-term supplementation of culture medium with essential fatty acids alters alpha-linolenic acid uptake in Caco-2 clone TC7. | 1998 | Can. J. Physiol. Pharmacol. | pmid:9923400 |
| Monteiro J et al. | Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. | 2013 | Can. J. Physiol. Pharmacol. | pmid:23746194 |
| Cunnane SC | The Canadian Society for Nutritional Sciences 1995 Young Scientist Award Lecture. Recent studies on the synthesis, beta-oxidation, and deficiency of linoleate and alpha-linolenate: are essential fatty acids more aptly named indispensable or conditionally dispensable fatty acids? | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909772 |
| Cunnane SC and Likhodii SS | 13C NMR spectroscopy and gas chromatograph--combustion--isotope ratio mass spectrometry: complementary applications in monitoring the metabolism of 13C-labelled polyunsaturated fatty acids. | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909789 |
| Narisawa T et al. | Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | 1994 | Cancer | pmid:7908858 |
| Koralek DO et al. | A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). | 2006 | Cancer Causes Control | pmid:16783606 |
| Astorg P | Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. | 2004 | Cancer Causes Control | pmid:15141138 |
| Carayol M et al. | Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. | 2010 | Cancer Causes Control | pmid:19921446 |
| Jackson MD et al. | Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. | 2012 | Cancer Causes Control | pmid:21984307 |
| Colditz GA | Changing dietary patterns and cancer prevention: alpha-linolenic acid health risks and benefits. | 2000 | Cancer Causes Control | pmid:11065003 |
| Oh K et al. | Dietary marine n-3 fatty acids in relation to risk of distal colorectal adenoma in women. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15824153 |
| De Stéfani E et al. | Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. | 2000 | Cancer Epidemiol. Biomarkers Prev. | pmid:10750674 |
| Berquin IM et al. | Multi-targeted therapy of cancer by omega-3 fatty acids. | 2008 | Cancer Lett. | pmid:18479809 |
| Kumar GS and Das UN | Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. | 1995 | Cancer Lett. | pmid:7757958 |
| Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
| Futakuchi M et al. | Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | 2002 | Cancer Lett. | pmid:11867197 |
| Franke AA et al. | Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. | 1994 | Cancer Lett. | pmid:7910514 |
| Agatha G et al. | Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. | 2001 | Cancer Lett. | pmid:11597788 |
| Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
| Lok E et al. | The effect of different levels of dietary alpha-linolenic and other fatty acids on mammary gland ductular cell proliferation in female Swiss Webster mice. | 1995 | Cancer Lett. | pmid:7600535 |
| Kokura S et al. | Efficacy of hyperthermia and polyunsaturated fatty acids on experimental carcinoma. | 1997 | Cancer Res. | pmid:9187121 |
| Sauer LA et al. | Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. | 2000 | Cancer Res. | pmid:11016660 |
| Hirose M et al. | Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. | 1990 | Carcinogenesis | pmid:2110511 |
| Komaki C et al. | Synergistic suppression of azoxymethane-induced foci of colonic aberrant crypts by the combination of beta-carotene and perilla oil in rats. | 1996 | Carcinogenesis | pmid:8824511 |
| Onogi N et al. | Suppressing effect of perilla oil on azoxymethane-induced foci of colonic aberrant crypts in rats. | 1996 | Carcinogenesis | pmid:8681445 |
| Tou JC and Thompson LU | Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures. | 1999 | Carcinogenesis | pmid:10469631 |
| Tsuzuki T et al. | Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. | 2004 | Carcinogenesis | pmid:14963014 |
| Pan P et al. | Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles. | 2015 | Carcinogenesis | pmid:26246425 |
| Duda MK et al. | omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential. | 2009 | Cardiovasc. Res. | pmid:19474179 |
| Carotenuto F et al. | A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. | 2013 | Cardiovasc. Res. | pmid:24042018 |
| Ander BP et al. | Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. | 2007 | Cardiovasc. Res. | pmid:17059813 |
| Hemmings SJ et al. | The effects of dietary flaxseed on the Fischer 344 rat: II. Liver gamma-glutamyltranspeptidase activity. | 2004 Jul-Aug | Cell Biochem. Funct. | pmid:15248182 |
| Novo C et al. | Altered fatty acid membrane composition modifies lymphocyte localization in vivo. | 1987 | Cell. Immunol. | pmid:2882861 |
| Wróbel A | Decrease in 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO) EPR signal in peroxynitrite-treated erythrocyte membranes. | 2001 | Cell. Mol. Biol. Lett. | pmid:11753439 |
| Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
| Carrillo C et al. | Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. | 2011 | Cell. Physiol. Biochem. | pmid:21471726 |
| Vinggaard AM et al. | Arf and RhoA regulate both the cytosolic and the membrane-bound phospholipase D from human placenta. | 1997 | Cell. Signal. | pmid:9113419 |
| Wagner W and Nootbaar-Wagner U | Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids. | 1997 | Cephalalgia | pmid:9137851 |
| Blanco M et al. | Ischemic preconditioning: a novel target for neuroprotective therapy. | 2006 | Cerebrovasc. Dis. | pmid:16651813 |