alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Del Castillo ML et al. | Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. | 2004 | J. Agric. Food Chem. | pmid:14969555 |
| Salvati S et al. | Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. | 2004 | Neurochem. Int. | pmid:14643750 |
| De Moraes CM and Mescher MC | Biochemical crypsis in the avoidance of natural enemies by an insect herbivore. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15184664 |
| Wijendran V and Hayes KC | Dietary n-6 and n-3 fatty acid balance and cardiovascular health. | 2004 | Annu. Rev. Nutr. | pmid:15189133 |
| Nguyen LQ et al. | Influence of dietary linseed, fish and coconut oil on growth performance of growing pigs kept on small holdings in central Vietnam. | 2004 | J Anim Physiol Anim Nutr (Berl) | pmid:15189425 |
| Zhang HY et al. | Isolation and functional assessment of a tomato proteinase inhibitor II gene. | 2004 | Plant Physiol. Biochem. | pmid:15191748 |
| Chuang SS et al. | CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. | 2004 | J. Biol. Chem. | pmid:14660610 |
| Dybkowska E et al. | [The comparison of fat, trans isomers and cholesterol intake in the diet of Warsaw inhabitants in relation to Polish food ration]. | 2004 | Rocz Panstw Zakl Hig | pmid:19097583 |
| Valenzuela A et al. | Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. | 2004 | Ann. Nutr. Metab. | pmid:14639043 |
| de Groot RH et al. | Alpha-linolenic acid supplementation during human pregnancy does not effect cognitive functioning. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643178 |
| Vecchini A et al. | Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. | 2004 | J. Lipid Res. | pmid:14563831 |
| López-Alarcón M et al. | Breastfeeding protects against the anorectic response to infection in infants: possible role of DHA. | 2004 | Adv. Exp. Med. Biol. | pmid:15384603 |
| Morise A et al. | Dose effect of alpha-linolenic acid on PUFA conversion, bioavailability, and storage in the hamster. | 2004 | Lipids | pmid:15357020 |
| Kim HK et al. | Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. | 2004 | J. Nutr. Biochem. | pmid:15302084 |
| Walters D et al. | Antifungal activities of four fatty acids against plant pathogenic fungi. | 2004 | Mycopathologia | pmid:15008350 |
| Zhao A et al. | Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. | 2004 | DNA Cell Biol. | pmid:15307955 |
| de Lorgeril M and Salen P | Alpha-linolenic acid and coronary heart disease. | 2004 | Nutr Metab Cardiovasc Dis | pmid:15330276 |
| Kuklev DV and Smith WL | Synthesis of four isomers of parinaric acid. | 2004 | Chem. Phys. Lipids | pmid:15351273 |
| Leitzmann MF et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. | 2004 | Am. J. Clin. Nutr. | pmid:15213050 |
| Waylan AT et al. | Effect of flax supplementation and growth promotants on lipoprotein lipase and glycogenin messenger RNA concentrations in finishing cattle. | 2004 | J. Anim. Sci. | pmid:15217016 |
| Jia Q et al. | Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. | 2004 | J. Nutr. | pmid:15173396 |
| Bemelmans WJ et al. | Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. | 2004 | Eur J Clin Nutr | pmid:15220952 |
| Moriguchi T et al. | Effects of an n-3-deficient diet on brain, retina, and liver fatty acyl composition in artificially reared rats. | 2004 | J. Lipid Res. | pmid:15175358 |
| Burdge G | Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. | 2004 | Curr Opin Clin Nutr Metab Care | pmid:15075703 |
| Fraser TC et al. | Expression of the Isochrysis C18-delta9 polyunsaturated fatty acid specific elongase component alters Arabidopsis glycerolipid profiles. | 2004 | Plant Physiol. | pmid:15173563 |
| Padilla S et al. | Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity. | 2004 | J. Biol. Chem. | pmid:15078893 |
| Nelson TL and Hickey MS | Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males. | 2004 | Cytokine | pmid:15157896 |
| Astorg P | Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. | 2004 | Cancer Causes Control | pmid:15141138 |
| Javadi M et al. | The effect of six different C18 fatty acids on body fat and energy metabolism in mice. | 2004 | Br. J. Nutr. | pmid:15469642 |
| Nielsen GS et al. | Formation of volatile compounds in model experiments with crude leek (Allium ampeloprasum Var. Lancelot) enzyme extract and linoleic acid or linolenic acid. | 2004 | J. Agric. Food Chem. | pmid:15080639 |
| Torstensen BE and Stubhaug I | Beta-oxidation of 18:3n-3 in Atlantic salmon (Salmo salar L.) hepatocytes treated with different fatty acids. | 2004 | Lipids | pmid:15134142 |
| Delmonte P et al. | Synthesis, isolation, and GC analysis of all the 6,8- to 13,15-cis/trans conjugated linoleic acid isomers. | 2004 | Lipids | pmid:15134147 |
| Ander BP et al. | Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. | 2004 | J. Nutr. | pmid:15570021 |
| Speake BK et al. | Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. | 2004 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:15085383 |
| Rallidis LS et al. | The effect of diet enriched with alpha-linolenic acid on soluble cellular adhesion molecules in dyslipidaemic patients. | 2004 | Atherosclerosis | pmid:15135261 |
| de Lorgeril M and Salen P | alpha-linolenic acid, coronary heart disease, and prostate cancer. | 2004 | J. Nutr. | pmid:15570041 |
| Kodas E et al. | Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. | 2004 | J. Neurochem. | pmid:15086526 |
| Sun L et al. | Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618634 |
| Frey M et al. | Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects. | 2004 | Phytochemistry | pmid:15110684 |
| Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
| Truitt CL et al. | A plasma membrane protein from Zea mays binds with the herbivore elicitor volicitin. | 2004 | Plant Cell | pmid:14729912 |
| Giamarellos-Bourboulis EJ et al. | n-6 polyunsaturated fatty acids enhance the activities of ceftazidime and amikacin in experimental sepsis caused by multidrug-resistant Pseudomonas aeruginosa. | 2004 | Antimicrob. Agents Chemother. | pmid:15561848 |
| de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
| Bertrandt J et al. | Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. | 2004 | Nahrung | pmid:15146965 |
| Truitt CL and Paré PW | In situ translocation of volicitin by beet armyworm larvae to maize and systemic immobility of the herbivore elicitor in planta. | 2004 | Planta | pmid:14685859 |
| Hauswirth CB et al. | High omega-3 fatty acid content in alpine cheese: the basis for an alpine paradox. | 2004 | Circulation | pmid:14676141 |
| Rabinovitz S et al. | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). | 2004 | Psychoneuroendocrinology | pmid:14604595 |
| Fleshner N et al. | Dietary fat and prostate cancer. | 2004 | J. Urol. | pmid:14713748 |
| Bloedon LT and Szapary PO | Flaxseed and cardiovascular risk. | 2004 | Nutr. Rev. | pmid:14995053 |
| Menendez JA et al. | Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. | 2004 | Int. J. Oncol. | pmid:15138577 |
| Lissak A et al. | Oxidative stress indices in seminal plasma, as measured by the thermochemiluminescence assay, correlate with sperm parameters. | 2004 | Fertil. Steril. | pmid:15019811 |
| Simopoulos AP | Omega-3 fatty acids and antioxidants in edible wild plants. | 2004 | Biol. Res. | pmid:15455656 |
| Ros E et al. | A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. | 2004 | Circulation | pmid:15037535 |
| Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
| Brouwer IA et al. | Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. | 2004 | J. Nutr. | pmid:15051847 |
| Maffei M et al. | Effects of feeding Spodoptera littoralis on lima bean leaves. I. Membrane potentials, intracellular calcium variations, oral secretions, and regurgitate components. | 2004 | Plant Physiol. | pmid:15051862 |
| Lee JH et al. | Feeding encapsulated ground full-fat soybeans to increase polyunsaturated fat concentrations and effects on flavor volatiles in fresh lamb. | 2004 | J. Anim. Sci. | pmid:15446490 |
| Dobson G et al. | Comparison of fatty acid and polar lipid contents of tubers from two potato species, Solanum tuberosum and Solanum phureja. | 2004 | J. Agric. Food Chem. | pmid:15453705 |
| Tsuzuki T et al. | Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and alpha-tocopherol. | 2004 | Lipids | pmid:15506243 |
| Paschos GK et al. | Background diet influences the anti-inflammatory effect of alpha-linolenic acid in dyslipidaemic subjects. | 2004 | Br. J. Nutr. | pmid:15522134 |
| Wang YW et al. | Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. | 2004 | Poult. Sci. | pmid:15615018 |
| Zhao G et al. | Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. | 2004 | J. Nutr. | pmid:15514264 |
| Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
| Tsuzuki T et al. | Tumor growth suppression by alpha-eleostearic acid, a linolenic acid isomer with a conjugated triene system, via lipid peroxidation. | 2004 | Carcinogenesis | pmid:14963014 |
| Colazo MG et al. | Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed. | 2004 | Theriogenology | pmid:15036999 |
| Trommer H et al. | Mass spectrometric examinations of stratum corneum lipid models exposed to ultraviolet irradiation. | 2003 Sep-Oct | Skin Pharmacol. Appl. Skin Physiol. | pmid:12907834 |
| Bavelaar FJ and Beynen AC | Severity of atherosclerosis in parrots in relation to the intake of alpha-linolenic acid. | 2003 Jul-Sep | Avian Dis. | pmid:14562883 |
| Flaxseed oil: healthful or harmful for men? | 2003 | Harv Mens Health Watch | pmid:14505958 | |
| Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
| Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
| [Dietary management of lipid disorders. Plant oil protects hearts of diabetic patients]. | 2003 | MMW Fortschr Med | pmid:14655490 | |
| Ainai T et al. | Efficient total synthesis of 12-oxo-PDA and OPC-8:0. | 2003 | J. Org. Chem. | pmid:14510562 |
| Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
| Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
| Erkkilä AT et al. | n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. | 2003 | Am. J. Clin. Nutr. | pmid:12816772 |
| Rallidis LS et al. | Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. | 2003 | Atherosclerosis | pmid:12818406 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Gavino VC et al. | Kinetic analysis of the selectivity of acylcarnitine synthesis in rat mitochondria. | 2003 | Lipids | pmid:12848298 |
| Schmelz EA et al. | Nitrogen deficiency increases volicitin-induced volatile emission, jasmonic acid accumulation, and ethylene sensitivity in maize. | 2003 | Plant Physiol. | pmid:12970495 |
| Lang-Lazdunski L et al. | Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. | 2003 | J. Vasc. Surg. | pmid:12947278 |
| Morel C et al. | Isoflavones as potentiators of antibacterial activity. | 2003 | J. Agric. Food Chem. | pmid:12952418 |
| Schempp H et al. | Antioxidative properties of Iberis amara extracts in biochemical model reactions. | 2003 | Arzneimittelforschung | pmid:13677247 |
| AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
| Langelier B et al. | Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. | 2003 | J. Neurosci. Res. | pmid:13130515 |
| Bazinet RP et al. | Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. | 2003 | J. Lipid Res. | pmid:12576513 |
| Acar N et al. | Modification of the dopaminergic neurotransmitters in striatum, frontal cortex and hippocampus of rats fed for 21 months with trans isomers of alpha-linolenic acid. | 2003 | Neurosci. Res. | pmid:12657450 |
| Finnegan YE et al. | Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12663273 |
| Baylin A et al. | Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. | 2003 | Circulation | pmid:12668490 |
| Wallace FA et al. | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. | 2003 | Br. J. Nutr. | pmid:12720588 |
| Bakshi A et al. | Gamma-linolenic acid therapy of human gliomas. | 2003 | Nutrition | pmid:12679162 |
| Tsydendambaev VD and Vereshchagin AG | Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. | 2003 | J. Agric. Food Chem. | pmid:12590468 |
| Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
| Djoussé L et al. | Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:14668270 |
| Suresh Y and Das UN | Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. | 2003 | Nutrition | pmid:12620523 |
| Fisher AJ et al. | The biochemical origin of pentenol emissions from wounded leaves. | 2003 | Phytochemistry | pmid:12482451 |
| Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
| Daligault F et al. | Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris. | 2003 | Phytochemistry | pmid:12877913 |
| Agostoni C | The difficult balance between dietary polyunsaturated fatty acids. | 2003 | Acta Paediatr. | pmid:14971782 |
| Thiombiano-Coulibaly N et al. | Seasonal and environmental effects on breast milk fatty acids in Burkina Faso and the need to improve the omega 3 PUFA content. | 2003 | Acta Paediatr. | pmid:14971787 |