alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lagarde M et al. | Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. | 2014 | Biochimie | pmid:25223888 |
| De Mel D and Suphioglu C | Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. | 2014 | Nutrients | pmid:25195602 |
| Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
| Carbonera F et al. | Effect of dietary replacement of sunflower oil with perilla oil on the absolute fatty acid composition in Nile tilapia (GIFT). | 2014 | Food Chem | pmid:24262550 |
| Saliba L et al. | Effect of feeding linseed oil in diets differing in forage to concentrate ratio: 1. Production performance and milk fat content of biohydrogenation intermediates of α-linolenic acid. | 2014 | J. Dairy Res. | pmid:24433586 |
| Dai XW et al. | Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. | 2014 | Atherosclerosis | pmid:24401220 |
| MartÃnez-RamÃrez HR et al. | Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs. | 2014 | J. Anim. Sci. | pmid:24305874 |
| Wennman A et al. | Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. | 2014 | Arch. Biochem. Biophys. | pmid:24857825 |
| Yang Q et al. | Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. | 2014 | BMC Complement Altern Med | pmid:25252789 |
| Hanke D et al. | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24140006 |
| Ivan M et al. | Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. | 2013 | Br. J. Nutr. | pmid:22850225 |
| Zheng JS et al. | Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. | 2013 | BMJ | pmid:23814120 |
| Sengupta A and Ghosh M | Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats. | 2013 | Indian J. Exp. Biol. | pmid:23678545 |
| Rao CV et al. | Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil. | 2013 | Nutr Cancer | pmid:23682783 |
| Hutchins AM et al. | Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. | 2013 | Nutr Res | pmid:23684438 |
| Simon MC et al. | Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes. | 2013 | Clin. Exp. Immunol. | pmid:23600826 |
| Foster M et al. | Inflammation markers predict zinc transporter gene expression in women with type 2 diabetes mellitus. | 2013 | J. Nutr. Biochem. | pmid:23643522 |
| Mapiye C et al. | Effects of feeding flaxseed or sunflower-seed in high-forage diets on beef production, quality and fatty acid composition. | 2013 | Meat Sci. | pmid:23669875 |
| Monge-Rojas R et al. | Changes in dietary intake and food sources of saturated and cis and trans unsaturated fatty acids in Costa Rican adolescents: 1996 versus 2006. | 2013 | Nutrition | pmid:23298971 |
| Molkentin J | Applicability of organic milk indicators to the authentication of processed products. | 2013 | Food Chem | pmid:23199986 |
| Ulas T et al. | Does α-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients? | 2013 | Int. J. Cardiol. | pmid:23200266 |
| Emery JA et al. | Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. | 2013 | PLoS ONE | pmid:23460861 |
| Zhao ML et al. | Enzymatic production of zero-trans plastic fat rich in α-linolenic acid and medium-chain fatty acids from highly hydrogenated soybean oil, Cinnamomum camphora seed oil, and perilla oil by lipozyme TL IM. | 2013 | J. Agric. Food Chem. | pmid:23350869 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
| Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
| Yan W et al. | Reply to manuscript IJC-D-12-04197 entitled "Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?" by MD Turgay Ulas. | 2013 | Int. J. Cardiol. | pmid:23313466 |
| Yan W et al. | Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. | 2013 | Int. J. Cardiol. | pmid:23102606 |
| Walker CG et al. | Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. | 2013 | Nutrition | pmid:23102888 |
| Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
| Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
| Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
| Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
| Perga ME et al. | Are cyanobacterial blooms trophic dead ends? | 2013 | Oecologia | pmid:23129401 |
| Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
| Yang YX et al. | Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. | 2013 | Animal | pmid:23031206 |
| Blanchard H et al. | Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23579035 |
| Hawkins A et al. | Effects of urea formaldehyde condensation polymer treatment of flaxseed on ruminal digestion and lactation in dairy cows. | 2013 | J. Dairy Sci. | pmid:23548281 |
| Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Kastner DW and Van Wagoner DR | Diet and atrial fibrillation: does α-linolenic acid, a plant derived essential fatty acid, have an impact? | 2013 | J Am Heart Assoc | pmid:23525415 |
| Fretts AM et al. | Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study. | 2013 | J Am Heart Assoc | pmid:23525429 |
| Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
| Monteiro J et al. | Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. | 2013 | Can. J. Physiol. Pharmacol. | pmid:23746194 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| Liu M et al. | Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. | 2013 | J. Lipid Res. | pmid:23740966 |
| Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
| Lai YH et al. | Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. | 2013 | Clin Nutr | pmid:23711994 |
| Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
| Sun L et al. | The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. | 2013 | Int. J. Biol. Sci. | pmid:23983614 |
| Kwon TY et al. | Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. | 2013 | J. Agric. Food Chem. | pmid:23968142 |
| Lund AS et al. | N-3 polyunsaturated fatty acids, body fat and inflammation. | 2013 | Obes Facts | pmid:23970146 |
| Lagunas B et al. | A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). | 2013 | Phytochemistry | pmid:23928132 |
| Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
| Yu X et al. | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis. | 2013 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:23896563 |
| MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
| Egusa Saiga A and Nishimura T | Antioxidative properties of peptides obtained from porcine myofibrillar proteins by a protease treatment in an Fe (II)-induced aqueous lipid peroxidation system. | 2013 | Biosci. Biotechnol. Biochem. | pmid:24200778 |
| Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Hoque M et al. | Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. | 2013 | PLoS ONE | pmid:24039698 |
| Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
| Arya E et al. | Effect of Perilla frutescens fixed oil on experimental esophagitis in albino Wistar rats. | 2013 | Biomed Res Int | pmid:24027769 |
| Carotenuto F et al. | A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. | 2013 | Cardiovasc. Res. | pmid:24042018 |
| Zhang W et al. | Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway. | 2013 | PLoS ONE | pmid:23861910 |
| Randall KM et al. | Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23867781 |
| Warstedt K and Duchén K | Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. | 2013 | Eur J Nutr | pmid:22584414 |
| Oliva ME et al. | Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24120122 |
| Coles L et al. | A model to predict the ATP equivalents of macronutrients absorbed from food. | 2013 | Food Funct | pmid:23233079 |
| Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
| Shen JH et al. | Effect of α-linolenic acid on streptozotocin-induced diabetic retinopathy indices in vivo. | 2013 | Arch. Med. Res. | pmid:24120388 |
| Végner L et al. | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. | 2013 | J. Med. Chem. | pmid:24088053 |
| Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
| Dai J et al. | Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. | 2013 | Lipids Health Dis | pmid:23663688 |
| Khaw KT | Dietary fats and breast cancer risk. | 2013 | BMJ | pmid:23861431 |
| Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
| Ghisolfi J et al. | Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. | 2013 | Public Health Nutr | pmid:23098567 |
| Katrangi W et al. | Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. | 2013 | Lipids | pmid:23440519 |
| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| Yi LT et al. | Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. | 2013 | J Ethnopharmacol | pmid:23506995 |
| Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
| Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
| Meijerink J et al. | N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. | 2013 | Br. J. Pharmacol. | pmid:23088259 |
| Chechetkin IR et al. | Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. | 2013 | Phytochemistry | pmid:24042063 |
| Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
| Zhang W et al. | Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. | 2013 | VASA | pmid:24220118 |
| Rodriguez-Leyva D et al. | Potent antihypertensive action of dietary flaxseed in hypertensive patients. | 2013 | Hypertension | pmid:24126178 |
| Hoffmann I and Oliw EH | Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum. | 2013 | J. Lipid Res. | pmid:24082064 |
| Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
| Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
| Niculescu MD et al. | Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. | 2013 | FASEB J. | pmid:22997227 |
| Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
| Shin JA et al. | Preparation of recombined milk using modified butterfats containing α-linolenic acid. | 2013 | J. Food Sci. | pmid:23278855 |
| Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
| Botsoglou E et al. | Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22716021 |
| Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
| Gladine C et al. | Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. | 2013 | J. Nutr. Biochem. | pmid:22784432 |
| Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
| Rahman H et al. | Development of low-linolenic acid Brassica oleracea lines through seed mutagenesis and molecular characterization of mutants. | 2013 | Theor. Appl. Genet. | pmid:23475317 |
| Wei M et al. | Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. | 2013 | J Tradit Chin Med | pmid:23789212 |
| Esselburn KM et al. | Intake of specific fatty acids and fat alters growth, health, and titers following vaccination in dairy calves. | 2013 | J. Dairy Sci. | pmid:23810586 |